p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue PLoS Genetics Année : 2017

p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis

Résumé

The importance of regulated necrosis in pathologies such as cerebral stroke and myocardial infarction is now fully recognized. However, the physiological relevance of regulated necrosis remains unclear. Here, we report a conserved role for p53 in regulating necrosis in Drosophila and mammalian spermatogenesis. We found that Drosophila p53 is required for the programmed necrosis that occurs spontaneously in mitotic germ cells during spermatogenesis. This form of necrosis involved an atypical function of the initiator caspase Dronc/Caspase 9, independent of its catalytic activity. Prevention of p53-dependent necrosis resulted in testicular hyperplasia, which was reversed by restoring necrosis in spermatogonia. In mouse testes, p53 was required for heat-induced germ cell necrosis, indicating that regulation of necrosis is a primordial function of p53 conserved from invertebrates to vertebrates. Drosophila and mouse spermatogenesis will thus be useful models to identify inducers of necrosis to treat cancers that are refractory to apoptosis.
Fichier principal
Vignette du fichier
journal.pgen.1007024.pdf (19.86 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

inserm-02157622 , version 1 (17-06-2019)

Identifiants

Citer

Francesco Napoletano, Benjamin Gibert, Keren Yacobi-Sharon, Stéphane Vincent, Clémentine Favrot, et al.. p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis. PLoS Genetics, 2017, 13 (9), pp.e1007024. ⟨10.1371/journal.pgen.1007024⟩. ⟨inserm-02157622⟩
119 Consultations
50 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More