Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012, Crit Care Med, vol.41, pp.580-637, 2013. ,
Structure and functions of the endothelial cell protein C receptor, Crit Care Med, vol.32, pp.298-301, 2004. ,
Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor, J Biol Chem, vol.269, pp.26486-91, 1994. ,
Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway, Circulation, vol.96, pp.3633-3673, 1997. ,
Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis, J Biol Chem, vol.276, pp.11199-203, 2001. ,
Activation of endothelial cell protease activated receptor 1 by the protein C pathway, Science, vol.296, pp.1880-1882, 2002. ,
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis, Nat Med, vol.13, pp.1349-58, 2007. ,
Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells, J Biol Chem, vol.281, pp.20077-84, 2006. ,
Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium, J Biol Chem, vol.282, pp.11849-57, 2007. ,
Characterization and regulation of the 5?-flanking region of the murine endothelial protein C receptor gene, J Biol Chem, vol.275, pp.12481-12489, 2000. ,
Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes, Blood, vol.91, pp.725-732, 1998. ,
Metalloproteolytic release of endothelial cell protein C receptor, J Biol Chem, vol.275, pp.6038-6082, 2000. ,
Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17, J Thromb Haemost Jth, vol.5, pp.395-402, 2007. ,
Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma, Blood, vol.111, pp.3442-51, 2008. ,
Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function, J Biol Chem, vol.275, pp.5447-52, 2000. ,
A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis, Blood, vol.103, pp.1311-1319, 2004. ,
Shedding of endothelial protein C receptor contributes to vasculopathy and renal injury in lupus: in vivo and in vitro evidence, Kidney Int, vol.68, pp.110-130, 2005. ,
Early rise in circulating endothelial protein C receptor correlates with poor outcome in severe sepsis, Intensive Care Med, vol.37, pp.950-956, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-00582321
, Regression Shrinkage and Selection via the Lasso Robert Tibshirani, J R Stat Soc. Series B (Methodological), vol.58, issue.1, pp.267-288, 1996.
The limitations of risk factors as prognostic tools, N Engl J Med, vol.355, pp.2615-2622, 2006. ,
Prognostic markers: data misinterpretation often leads to overoptimistic conclusions, Am J Transplant, vol.12, pp.1060-1061, 2012. ,
Time dependent ROC curves for the estimation of true prognostic capacity of microarray data, Stat Appl Genet Mol Biol, vol.11, issue.1, 2012. ,
R: A language and environment for statistical computing, Vienna: R Found. Stat. Comput, 2009. ,
Dysfunction of endothelial protein C activation in severe meningococcal sepsis, N Engl J Med, vol.345, pp.408-424, 2001. ,
A comparative study of the protein C pathway in septic and nonseptic patients with organ failure, Am J Respir Crit Care Med, vol.176, pp.878-85, 2007. ,
Circulating endothelial cell protein C receptor: endothelial regulation and cumulative impact of gender and A3 haplotype, J Vasc Res, vol.48, pp.336-382, 2011. ,
Endothelial protein C receptor polymorphisms and risk of severe sepsis in critically ill patients, Intensive Care Med, vol.39, pp.1752-1761, 2013. ,
Elevated soluble endothelial protein C receptor levels at ICU admission are associated with sepsis development, Minerva Anestesiol, vol.81, issue.2, pp.125-159, 2015. ,
Severe malaria is associated with parasite binding to endothelial protein C receptor, Nature, vol.498, issue.7455, pp.502-507, 2013. ,
Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children, Blood, vol.122, issue.5, pp.842-51, 2013. ,
EPCR and malaria severity: the center of a perfect storm, Trends Parasitol, vol.33, issue.4, pp.295-308, 2017. ,
The H3 haplotype of the EPCR gene determines high sEPCR levels in critically ill septic patients, Infect Dis Ther, vol.7, issue.1, pp.3-14, 2018. ,