D. Dufrane, R. M. Goebbels, and P. Gianello, Alginate macroencapsulation of pig islets allows correction of streptozotocin-induced diabetes in primates up to 6 months without immunosuppression, Transplantation, vol.90, pp.1054-1062, 2010.

T. Kobayashi, G. Harb, and R. V. Rajotte, Immune mechanisms associated with the rejection of encapsulated neonatal porcine islet xenografts, Xenotransplantation, vol.13, pp.547-559, 2006.

B. J. Hering, M. Wijkstrom, and M. L. Graham, Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates, Nat Med, vol.12, pp.301-303, 2006.

K. Cardona, G. S. Korbutt, and Z. Milas, Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways, Nat Med, vol.12, pp.304-306, 2006.

D. J. Van-der-windt, R. Bottino, and A. Casu, Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets, Am J Transplant, vol.9, pp.2716-2726, 2009.

P. Thompson, K. Cardona, and M. Russell, CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates, Am J Transplant, vol.11, pp.947-957, 2011.
DOI : 10.1111/j.1600-6143.2011.03509.x

URL : https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-6143.2011.03509.x

G. S. Korbutt, J. F. Elliott, Z. Ao, D. K. Smith, G. L. Warnock et al., Large scale isolation, growth, and function of porcine neonatal islet cells, J Clin Invest, vol.97, pp.2119-2129, 1996.

D. K. Cooper, E. Koren, and R. Oriol, Oligosaccharides and discordant xenotransplantation, Immunol Rev, vol.141, pp.31-58, 1994.
DOI : 10.1111/j.1600-065x.1994.tb00871.x

U. Galili, R. E. Mandrell, R. M. Hamadeh, S. B. Shohet, and J. M. Griffiss, Interaction between human natural anti-alpha-galactosyl immunoglobulin G and bacteria of the human flora, Infect Immun, vol.56, pp.1730-1737, 1988.

A. Salama, G. Evanno, J. Harb, and J. P. Soulillou, Potential deleterious role of anti-Neu5Gc antibodies in xenotransplantation, Xenotransplantation, vol.22, pp.85-94, 2015.
URL : https://hal.archives-ouvertes.fr/inserm-02147779

A. Irie and A. Suzuki, CMP-N-acetylneuraminic acid hydroxylase is exclusively inactive in humans, Biochem Biophys Res Commun, vol.248, pp.330-333, 1998.

H. Komoda, S. Miyagawa, and T. Kubo, A study of the xenoantigenicity of adult pig islets cells, Xenotransplantation, vol.11, pp.237-246, 2004.

T. Omori, T. Nishida, and H. Komoda, A study of the xenoantigenicity of neonatal porcine islet-like cell clusters (NPCC) and the efficiency of adenovirusmediated DAF (CD55) expression, Xenotransplantation, vol.13, pp.455-464, 2006.

H. Tahara, K. Ide, and N. B. Basnet, Immunological property of antibodies against N-glycolylneuraminic acid epitopes in cytidine monophospho-Nacetylneuraminic acid hydroxylase-deficient mice, J Immunol, vol.184, pp.3269-3275, 2010.

S. Kavaler, H. Morinaga, and A. Jih, Pancreatic beta-cell failure in obese mice with human-like CMP-Neu5Ac hydroxylase deficiency, FASEB J, vol.25, pp.1887-1893, 2011.

X. Bourges, P. Weiss, G. Daculsi, and G. Legeay, Synthesis and general properties of silated-hydroxypropyl methylcellulose in prospect of biomedical use, Adv Colloid Interface Sci, vol.99, pp.215-228, 2002.
URL : https://hal.archives-ouvertes.fr/inserm-00198799

V. Padler-karavani, H. Yu, and H. Cao, Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: potential implications for disease, Glycobiology, vol.18, pp.818-830, 2008.

L. Scobie, V. Padler-karavani, L. Bas-bernardet, and S. , Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts, J Immunol, vol.191, pp.2907-2915, 2013.

D. J. Van-der-windt, M. Marigliano, and J. He, Early islet damage after direct exposure of pig islets to blood: has humoral immunity been underestimated?, Cell Transplant, vol.21, pp.1791-1802, 2012.

A. J. Lutz, P. Li, and J. L. Estrada, Double knockout pigs deficient in N-glycolylneuraminic acid and galactose a-1,3-galactose reduce the humoral barrier to xenotransplantation, Xenotransplantation, vol.20, pp.27-35, 2013.

S. Miyagawa, H. Matsunari, and M. Watanabe, Generation of a1,3-galactosyltransferase and cytidine monophospho-N-acetylneuraminic acid hydroxylase gene double-knockout pigs, J Reprod Dev, vol.61, pp.449-457, 2015.

P. Li, J. L. Estrada, and C. Burlak, Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection, Xenotransplantation, vol.22, pp.20-31, 2015.

A. Casu, G. J. Echeverri, and R. Bottino, Insulin secretion and glucose metabolism in alpha 1,3-galactosyltransferase knock-out pigs compared to wildtype pigs, Xenotransplantation, vol.17, pp.131-139, 2010.

E. Manell, P. Hedenqvist, A. Svensson, and M. Jensen-waern, Establishment of a refined oral glucose tolerance test in pigs, and assessment of insulin, glucagon and glucagon-like peptide-1 responses, PLoS One, vol.11, p.148896, 2016.

C. Burlak, L. L. Paris, and A. J. Lutz, Reduced binding of human antibodies to cells from GGTA1/CMAH KO pigs, Am J Transplant, vol.14, pp.1895-1900, 2014.