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Journal articles
Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference
Timothy Goodship
1
H Cook
2
Fadi Fakhouri
3, 4
Fernando Fervenza
5
Véronique Frémeaux-Bacchi
6
David Kavanagh
1
Carla Nester
7, 8
Marina Noris
9
Matthew Pickering
2
Santiago Rodríguez de Córdoba
10
Lubka Roumenina
11, 12, 13, 14
Sanjeev Sethi
15
Richard Smith
7, 8, *
*
Corresponding author
Timothy H.J. Goodship 1
Author
H Terence Cook 2
Author
Fadi Fakhouri 3, 4
Author
Fernando Fervenza 5
Author
Véronique Frémeaux-Bacchi 6
Author
David Kavanagh 1
Author
Carla M. Nester 7, 8
Author
Marina Noris 9
Author
Matthew C. Pickering 2
Author
Santiago Rodríguez de Córdoba 10
Author
Lubka T. Roumenina 11, 12, 13, 14
Author
Sanjeev Sethi 15
Author
Richard J.H. Smith 7, 8
Correspondent author Employer institution : Smith Watkins Trumpets
1
Institute of Genetic Medicine [Newcastle, U.K.] (Central Parkway, Newcastle-upon-Tyne, NE1 3BZ - United Kingdom)
- Newcastle University [Newcastle] (Newcastle upon Tyne NE1 7RU - United Kingdom)
2
Department of Medicine - Centre for Complement and Inflammation Research [London, UK] (London W12 0NN. - United Kingdom)
- Imperial College London (South Kensington Campus, London SW7 2AZ - United Kingdom)
3
U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie (CHU Nantes - Hôtel Dieu - 30 Bd Jean Monnet 44093 Nantes Cedex 01. - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1064 (101, rue de Tolbiac, 75013 Paris - France)
- UFR MEDECINE - Université de Nantes - UFR de Médecine et des Techniques Médicales (1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1 - France)
- UN - Université de Nantes (1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1 - France)
4
Département de néphrologie et d'immunologie [CHU Nantes] (France)
- CHU Nantes - Centre hospitalier universitaire de Nantes (1 Place Alexis-Ricordeau, 44000 Nantes - France)
5
Department of Nephrology and Hypertension [Rochester, MN, USA] (United States)
- Mayo Clinic [Rochester] (200 First St. SW Rochester, MN 55905 - United States)
6
HEGP - Hôpital Européen Georges Pompidou [APHP] (20, rue Leblanc, 75015 Paris - France)
7
Carver College of Medicine - Molecular Otolaryngology and Renal Research Laboratories [Iowa City, IA, USA] (United States)
- University of Iowa [Iowa City] (Iowa City, IA 52242 - United States)
- Carver College of Medicine, University of Iowa (United States)
8
Department of Internal Medicine [Iowa City] (200 Hawkins Drive
Iowa City, Iowa 52242 - United States)
- Carver College of Medicine [Iowa City] (200 Hawkins Drive, Iowa City, IA 52242 - United States)
- University of Iowa [Iowa City] (Iowa City, IA 52242 - United States)
10
CSIC - Centro de Investigaciones Biológicas (Ramiro de Maeztu Madrid - Spain)
- CSIC - Consejo Superior de Investigaciones Científicas [Madrid] (Serrano 117, 28006 Madrid - Spain)
11
CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers (15 rue de l'Ecole de Médecine - Bâtiment B -
75270 Paris Cedex 06 - France)
- EPHE - École pratique des hautes études (4-14 Rue Ferrus, 75014 Paris - France)
- PSL - Université Paris sciences et lettres (60 rue Mazarine 75006 Paris - France)
- UPD7 - Université Paris Diderot - Paris 7 : UMR_S_1138 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
- UPD5 - Université Paris Descartes - Paris 5 : UMR_S_1138 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1138 (101, rue de Tolbiac, 75013 Paris - France)
- SU - Sorbonne Université (21 rue de l’École de médecine - 75006 Paris - France)
12
UPD5 - Université Paris Descartes - Paris 5 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
13
USPC - Université Sorbonne Paris Cité (Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris - France)
14
UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
15
Department of Laboratory Medicine and Pathology (Mayo Clinic Rochester) (United States)
- Mayo Clinic [Rochester] (200 First St. SW Rochester, MN 55905 - United States)
Abstract : In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) complement plays a primary role in disease pathogenesis. Herein we report the outcome of a 2015 Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference where key issues in the management of these 2 diseases were considered by a global panel of experts. Areas addressed included renal pathology, clinical phenotype and assessment, genetic drivers of disease, acquired drivers of disease, and treatment strategies. In order to help guide clinicians who are caring for such patients, recommendations for best treatment strategies were discussed at length, providing the evidence base underpinning current treatment options. Knowledge gaps were identified and a prioritized research agenda was proposed to resolve outstanding controversial issues.
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Journal articles
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https://www.hal.inserm.fr/inserm-02155926
Contributor : Sylvie Le Bihan <>
Submitted on : Friday, June 14, 2019 - 8:54:11 AM
Last modification on : Saturday, December 26, 2020 - 1:46:07 PM
Contributor : Sylvie Le Bihan <>
Submitted on : Friday, June 14, 2019 - 8:54:11 AM
Last modification on : Saturday, December 26, 2020 - 1:46:07 PM
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- HAL Id : inserm-02155926, version 1
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INSERM | UPMC | UNIV-PARIS5 | UNIV-NANTES | CRTI | SORBONNE-UNIVERSITE | UNIV-PARIS7 | CORDELIERS | EPHE | USPC | SU-SCIENCES | UNIV-PARIS | UP-SANTE | PSL | SU-TI
Citation
Timothy Goodship, H Cook, Fadi Fakhouri, Fernando Fervenza, Véronique Frémeaux-Bacchi, et al.. Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference. Kidney International, Nature Publishing Group, 2017. ⟨inserm-02155926⟩
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