Retinoids Issued from Hepatic Stellate Cell Lipid Droplet Loss as Potential Signaling Molecules Orchestrating a Multicellular Liver Injury Response - Archive ouverte HAL Access content directly
Journal Articles Cells Year : 2018

Retinoids Issued from Hepatic Stellate Cell Lipid Droplet Loss as Potential Signaling Molecules Orchestrating a Multicellular Liver Injury Response

(1) , (1) , (1) , (1)
1

Abstract

Hepatic stellate cells (HSCs) serve as the main body storage compartment for vitamin A through retinyl ester (RE)-filled lipid droplets (LDs). Upon liver injury, HSCs adopt a myofibroblastic phenotype characterized by an elevated expression of extracellular matrix proteins and a concomitant loss of LDs. On the one hand, LD breakdown has been suggested to provide the energy required for HSC activation into myofibroblast-like cells. On the other hand, this process could mitigate HSC activation following the transformation of released REs into retinoic acids (RAs), ligands for nuclear receptors exerting antifibrotic transcriptional regulatory activities in HSCs. Importantly, RAs may also constitute a means for HSCs to orchestrate the liver response to injury by triggering transcriptional effects in multiple additional surrounding liver cell populations. We envision that new approaches, such as single-cell technologies, will allow to better define how RAs are issued from LD loss in HSCs exert a multicellular control of the liver (patho)physiology.
Fichier principal
Vignette du fichier
cells-07-00137 (1).pdf (912.6 Ko) Télécharger le fichier
Loading...

Dates and versions

inserm-02154783 , version 1 (13-06-2019)

Identifiers

Cite

Marie Bobowski-Gerard, Francesco Paolo Zummo, Bart Staels, Jérôme Eeckhoute. Retinoids Issued from Hepatic Stellate Cell Lipid Droplet Loss as Potential Signaling Molecules Orchestrating a Multicellular Liver Injury Response. Cells, 2018, 7 (9), pii: E137. ⟨10.3390/cells7090137⟩. ⟨inserm-02154783⟩
29 View
109 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More