A Potential Role of Salmonella Infection in the Onset of Inflammatory Bowel Diseases

Abstract : Inflammatory bowel disease (IBD) includes a set of pathologies that result from a deregulated immune response that may affect any portion of the gastrointestinal tract. The most prevalent and defined forms of IBD are Crohn's disease and ulcerative colitis. Although the etiology of IBD is not well defined, it has been suggested that environmental and genetic factors contribute to disease development and that the interaction between these two factors can trigger the pathology. Diet, medication use, vitamin D status, smoking, and bacterial infections have been proposed to influence or contribute to the onset or development of the disease in susceptible individuals. The infection with pathogenic bacteria is a key factor that can influence the development and severity of this disease. Here, we present a comprehensive review of studies performed in human and mice susceptible to IBD, which supports the notion that infection with bacterial pathogens, such as Salmonella, could promote the onset of IBD due to permanent changes in the intestinal microbiota, disruption of the epithelial barrier and alterations of the intestinal immune response after infection.
Document type :
Journal articles
Complete list of metadatas

Cited literature [130 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02154782
Contributor : Ana Paula Dutra Azevedo <>
Submitted on : Thursday, June 13, 2019 - 8:12:38 AM
Last modification on : Tuesday, August 13, 2019 - 2:30:12 PM

File

fimmu-08-00191.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Barbara Schultz, Carolina Paduro, Geraldyne Salazar, Francisco Salazar-Echegarai, Valentina Sebastián, et al.. A Potential Role of Salmonella Infection in the Onset of Inflammatory Bowel Diseases. Frontiers in Immunology, Frontiers, 2017, 8, ⟨10.3389/fimmu.2017.00191⟩. ⟨inserm-02154782⟩

Share

Metrics

Record views

48

Files downloads

92