Organizing combinatorial transcription factor recruitment at cis -regulatory modules

Julie Dubois-Chevalier 1 Parisa Mazrooei 2 Mathieu Lupien 2 Bart Staels 1 Philippe Lefebvre 1 Jérôme Eeckhoute 1, *
* Corresponding author
1 EGID - Récepteurs nucléaires, maladies cardiovasculaires et diabète
2 MBP - Department of Medical Biophysics
Abstract : Gene transcriptional regulation relies on cis-regulatory DNA modules (CRMs), which serve as nexus sites for integration of multiple transcription factor (TF) activities. Here, we provide evidence and discuss recent literature indicating that TF recruitment to CRMs is organized into combinations of trans-regulatory protein modules (TRMs). We propose that TRMs are functional entities composed of TFs displaying the most highly interdependent chromatin binding which are, in addition, able to modulate their recruitment to CRMs through inter-TRM effects. These findings shed light on the architectural organization of TF recruitment encoded by their recognition motifs within CRMs.
Keywords : liver transcription factors trans-regulatory modules single nucleotide variants Chromatin binding cis-regulatory modules DNA recognition elements functional genomics
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Submitted on : Wednesday, June 12, 2019 - 3:49:04 PM
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Julie Dubois-Chevalier, Parisa Mazrooei, Mathieu Lupien, Bart Staels, Philippe Lefebvre, et al.. Organizing combinatorial transcription factor recruitment at cis -regulatory modules. Transcription, Taylor & Francis, 2018, 9 (4), pp.233-239. ⟨10.1080/21541264.2017.1394424⟩. ⟨inserm-02153895⟩

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