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Journal articles
Organizing combinatorial transcription factor recruitment at cis -regulatory modules
Abstract : Gene transcriptional regulation relies on cis-regulatory DNA modules (CRMs), which serve as nexus sites for integration of multiple transcription factor (TF) activities. Here, we provide evidence and discuss recent literature indicating that TF recruitment to CRMs is organized into combinations of trans-regulatory protein modules (TRMs). We propose that TRMs are functional entities composed of TFs displaying the most highly interdependent chromatin binding which are, in addition, able to modulate their recruitment to CRMs through inter-TRM effects. These findings shed light on the architectural organization of TF recruitment encoded by their recognition motifs within CRMs.
Cited literature [35 references]
https://www.hal.inserm.fr/inserm-02153895
Contributor : Marie-Hélène Derudas Connect in order to contact the contributor
Submitted on : Wednesday, June 12, 2019 - 3:49:04 PM
Last modification on : Tuesday, December 15, 2020 - 3:22:04 PM
Contributor : Marie-Hélène Derudas Connect in order to contact the contributor
Submitted on : Wednesday, June 12, 2019 - 3:49:04 PM
Last modification on : Tuesday, December 15, 2020 - 3:22:04 PM
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