Standardized and weighted time-dependent receiver operating characteristic curves to evaluate the intrinsic prognostic capacities of a marker by taking into account confounding factors

Abstract : Time-dependent receiver operating characteristic curves allow to evaluate the capacity of a marker to discriminate between subjects who experience the event up to a given prognostic time from those who are free of this event. In this article, we propose an inverse probability weighting estimator of a standardized and weighted time-dependent receiver operating characteristic curve. This estimator provides a measure of the prognostic capacities by taking into account potential confounding factors. We illustrate the robustness of the estimator by a simulation-based study and its usefulness by two applications in kidney transplantation.
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Journal articles
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https://www.hal.inserm.fr/inserm-02153739
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Submitted on : Wednesday, June 12, 2019 - 2:23:17 PM
Last modification on : Thursday, June 13, 2019 - 1:31:05 AM

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Florent Le Borgne, Christophe Combescure, Florence Gillaizeau, Magali Giral, Marion Chapal, et al.. Standardized and weighted time-dependent receiver operating characteristic curves to evaluate the intrinsic prognostic capacities of a marker by taking into account confounding factors. Statistical Methods in Medical Research, SAGE Publications, 2017, 27 (11), pp.3397-3410. ⟨10.1177/0962280217702416⟩. ⟨inserm-02153739⟩

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