Standardized and weighted time-dependent receiver operating characteristic curves to evaluate the intrinsic prognostic capacities of a marker by taking into account confounding factors - Archive ouverte HAL Access content directly
Journal Articles Statistical Methods in Medical Research Year : 2017

Standardized and weighted time-dependent receiver operating characteristic curves to evaluate the intrinsic prognostic capacities of a marker by taking into account confounding factors

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Christophe Combescure
  • Function : Author
Florence Gillaizeau
  • Function : Author
  • PersonId : 980825
Marion Chapal
  • Function : Author
Bruno Giraudeau
Yohann Foucher

Abstract

Time-dependent receiver operating characteristic curves allow to evaluate the capacity of a marker to discriminate between subjects who experience the event up to a given prognostic time from those who are free of this event. In this article, we propose an inverse probability weighting estimator of a standardized and weighted time-dependent receiver operating characteristic curve. This estimator provides a measure of the prognostic capacities by taking into account potential confounding factors. We illustrate the robustness of the estimator by a simulation-based study and its usefulness by two applications in kidney transplantation.
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Dates and versions

inserm-02153739 , version 1 (12-06-2019)

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Florent Le Borgne, Christophe Combescure, Florence Gillaizeau, Magali Giral, Marion Chapal, et al.. Standardized and weighted time-dependent receiver operating characteristic curves to evaluate the intrinsic prognostic capacities of a marker by taking into account confounding factors. Statistical Methods in Medical Research, 2017, 27 (11), pp.3397-3410. ⟨10.1177/0962280217702416⟩. ⟨inserm-02153739⟩
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