A. G. Jardine, R. S. Gaston, B. C. Fellstrom, and H. Holdaas, Prevention of cardiovascular disease in adult recipients of kidney transplants, Lancet, vol.378, pp.1419-1446, 2011.

J. Cunningham, F. Locatelli, and M. Rodriguez, Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options, Clin J Am Soc Nephrol, vol.6, p.21454719, 2011.

H. P. Tan, J. Donaldson, A. Basu, M. Unruh, P. Randhawa et al., Two hundred living donor kidney transplantations under alemtuzumab induction and tacrolimus monotherapy: 3-year follow-up, Am J Transplant, vol.9, pp.355-66, 2009.

O. Bestard, E. Crespo, M. Stein, M. Lucia, D. L. Roelen et al., Cross-validation of IFN-gamma Elispot assay for measuring alloreactive memory/effector T cell responses in renal transplant recipients, Am J Transplant, vol.13, p.23763435, 2013.

F. Bohne, M. Martinez-llordella, J. J. Lozano, R. Miquel, C. Benitez et al., Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation, J Clin Invest, vol.122, p.22156196, 2012.

J. J. Augustine, D. S. Siu, M. J. Clemente, J. A. Schulak, P. S. Heeger et al., Pre-transplant IFN-gamma ELISPOTs are associated with post-transplant renal function in African American renal transplant recipients, Am J Transplant, vol.5, pp.1971-1976, 2005.

P. Nickel, F. Presber, G. Bold, D. Biti, C. Schonemann et al., Enzyme-linked immunosorbent spot assay for donor-reactive interferon-gamma-producing cells identifies T-cell presensitization and correlates with graft function at 6 and 12 months in renal-transplant recipients, Transplantation, vol.78, p.15591953, 2004.

I. Ashoor, N. Najafian, Y. Korin, E. F. Reed, T. Mohanakumar et al., Standardization and cross validation of alloreactive IFNgamma ELISPOT assays within the clinical trials in organ transplantation consortium, Am J Transplant, vol.13, p.23710568, 2013.

O. Bestard, J. M. Cruzado, M. Lucia, E. Crespo, L. Casis et al., Prospective assessment of antidonor cellular alloreactivity is a tool for guidance of immunosuppression in kidney transplantation, Kidney Int, vol.84, pp.1226-1262, 2013.

T. Kawai, D. H. Sachs, B. Sprangers, T. R. Spitzer, S. L. Saidman et al., Long-term results in recipients of combined HLA-mismatched kidney and bone marrow transplantation without maintenance immunosuppression, Am J Transplant, vol.14, p.24903438, 2014.

K. Chan, D. Taube, C. Roufosse, T. Cook, P. Brookes et al., Kidney transplantation with minimized maintenance: alemtuzumab induction with tacrolimus monotherapy-an open label, randomized trial, Transplantation, vol.92, pp.774-80, 2011.

R. N. Barth, C. A. Janus, C. A. Lillesand, N. A. Radke, J. D. Pirsch et al., Outcomes at 3 years of a prospective pilot study of Campath-1H and sirolimus immunosuppression for renal transplantation, Transpl Int, vol.19, p.17018123, 2006.

X. C. Li and L. A. Turka, An update on regulatory T cells in transplant tolerance and rejection, Nat Rev Nephrol, vol.6, pp.577-83, 2010.

C. Mauri and P. A. Blair, Regulatory B cells in autoimmunity: developments and controversies, Nat Rev Rheumatol, vol.6, p.20856268, 2010.

J. A. Hutchinson, P. Riquelme, and E. K. Geissler, Human regulatory macrophages as a cell-based medicinal product, Curr Opin Organ Transplant, vol.17, p.22186091, 2012.

W. Gao, Y. Lu, E. Essawy, B. Oukka, M. Kuchroo et al., Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells, Am J Transplant, vol.7, p.17511761, 2007.

E. Krystufkova, A. Sekerkova, I. Striz, I. Brabcova, E. Girmanova et al., Regulatory T cells in kidney transplant recipients: the effect of induction immunosuppression therapy, Nephrol Dial Transplant, 2011.

A. Cherukuri, A. D. Salama, C. Carter, N. Smalle, R. Mccurtin et al., An analysis of lymphocyte phenotype after steroid avoidance with either alemtuzumab or basiliximab induction in renal transplantation, Am J Transplant, vol.12, p.22390816, 2012.

D. E. Hricik, R. N. Formica, P. Nickerson, D. Rush, R. L. Fairchild et al., Adverse Outcomes of Tacrolimus Withdrawal in Immune-Quiescent Kidney Transplant Recipients, J Am Soc Nephrol, 2015.

N. K. Tchao and L. A. Turka, Lymphodepletion and homeostatic proliferation: implications for transplantation, Am J Transplant, vol.12, pp.1079-90, 2012.

M. Feldmann and S. R. Maini, Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics, Immunol Rev, vol.223, pp.7-19, 2008.

H. Bruns, C. Meinken, P. Schauenberg, G. Harter, P. Kern et al., Anti-TNF immunotherapy reduces CD8+ T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans, J Clin Invest, vol.119, pp.1167-77, 2009.

B. Scallon, A. Cai, N. Solowski, A. Rosenberg, X. Y. Song et al., Binding and functional comparisons of two types of tumor necrosis factor antagonists, J Pharmacol Exp Ther, vol.301, p.11961039, 2002.

B. J. Scallon, M. A. Moore, H. Trinh, D. M. Knight, and J. Ghrayeb, Chimeric anti-TNF-alpha monoclonal antibody cA2 binds recombinant transmembrane TNF-alpha and activates immune effector functions, Cytokine, vol.7, pp.251-260, 1995.

A. Lugering, M. Schmidt, N. Lugering, H. G. Pauels, W. Domschke et al., Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway, Gastroenterology, vol.121, p.11677207, 2001.

G. V. Mazariegos, J. Reyes, I. R. Marino, A. J. Demetris, B. Flynn et al., Weaning of immunosuppression in liver transplant recipients, Transplantation, vol.63, p.9020325, 1997.

A. Vathsala, E. T. Ona, S. Y. Tan, S. Suresh, H. X. Lou et al., Randomized trial of Alemtuzumab for prevention of graft rejection and preservation of renal function after kidney transplantation, Transplantation, vol.80, p.16210963, 2005.

S. J. Knechtle, J. D. Pirsch, H. Fechner, J. Becker, B. N. Friedl et al., Campath-1H induction plus rapamycin monotherapy for renal transplantation: results of a pilot study, Am J Transplant, vol.3, 2003.

M. Matz, J. Beyer, D. Wunsch, M. F. Mashreghi, M. Seiler et al., Early post-transplant urinary IP-10 expression after kidney transplantation is predictive of short-and long-term graft function, Kidney Int, vol.69, pp.1683-90, 2006.

, RNAeasy 96 Handbook 01/2002. Section RNeay 96 protocol for RNA cleanup/II: Using spin technology, 2002.

P. Sagoo, E. Perucha, B. Sawitzki, S. Tomiuk, D. A. Stephens et al., Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans, Journal of Clinical Investigation, vol.120, pp.1848-61, 2010.

P. Sagoo, E. Perucha, B. Sawitzki, S. Tomiuk, D. A. Stephens et al., Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans, J Clin Invest, vol.120, pp.1848-61, 2010.

R. Edgar, M. Domrachev, and A. E. Lash, Gene Expression Omnibus: NCBI gene expression and hybridization array data repository, Nucleic Acids Res, vol.30, p.11752295, 2002.

A. I. Saeed, V. Sharov, J. White, J. Li, W. Liang et al., TM4: a free, open-source system for microarray data management and analysis, Biotechniques, vol.34, p.12613259, 2003.

U. Panzer, O. M. Steinmetz, R. R. Reinking, T. N. Meyer, S. Fehr et al., Compartment-specific expression and function of the chemokine IP-10/CXCL10 in a model of renal endothelial microvascular injury, J Am Soc Nephrol, vol.17, pp.454-64, 2006.

M. Chesneau, A. Pallier, F. Braza, G. Lacombe, L. Gallou et al., Unique B cell differentiation profile in tolerant kidney transplant patients, Am J Transplant, vol.14, pp.144-55, 2014.
URL : https://hal.archives-ouvertes.fr/hal-00974748

O. Viklicky, E. Krystufkova, I. Brabcova, A. Sekerkova, P. Wohlfahrt et al., B-cell-related biomarkers of tolerance are up-regulated in rejection-free kidney transplant recipients, Transplantation, vol.95, pp.148-54, 2013.

A. D. Kirk, N. A. Turgeon, and N. N. Iwakoshi, B cells and transplantation tolerance, Nat Rev Nephrol, vol.6, pp.584-93, 2010.

M. Jung, R. Sabat, J. Kratzschmar, H. Seidel, K. Wolk et al., Expression profiling of IL-10-regulated genes in human monocytes and peripheral blood mononuclear cells from psoriatic patients during IL-10 therapy, Eur J Immunol, vol.34, pp.481-93, 2004.

K. A. Newell, A. Asare, A. D. Kirk, T. D. Gisler, K. Bourcier et al., Identification of a B cell signature associated with renal transplant tolerance in humans, J Clin Invest, vol.120, p.20501946, 2010.

J. P. Pearl, J. Parris, D. A. Hale, S. C. Hoffmann, W. B. Bernstein et al., Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion, Am J Transplant, vol.5, pp.465-74, 2005.

H. Ekberg, H. Tedesco-silva, A. Demirbas, S. Vitko, B. Nashan et al., Reduced exposure to calcineurin inhibitors in renal transplantation, N Engl J Med, vol.357, pp.2562-75, 2007.

D. Glotz, B. Charpentier, D. Abramovicz, P. Lang, L. Rostaing et al., Thymoglobulin induction and sirolimus versus tacrolimus in kidney transplant recipients receiving mycophenolate mofetil and steroids, Transplantation, vol.89, pp.1511-1518, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00508079

C. Denecke, A. Reutzel-selke, B. Sawitzki, O. Boenisch, Z. Khalpey et al., Low-dose cyclosporine mediates donor hyporesponsiveness in a fully mismatched rat kidney transplant model, Transpl Immunol, vol.26, p.22414756, 2012.

J. R. Leventhal, M. J. Elliott, E. S. Yolcu, L. D. Bozulic, D. J. Tollerud et al., Immune reconstitution/ immunocompetence in recipients of kidney plus hematopoietic stem/facilitating cell transplants, Transplantation, vol.99, pp.288-98, 2015.

J. D. Scandling, S. Busque, J. A. Shizuru, R. Lowsky, R. Hoppe et al., Chimerism, graft survival, and withdrawal of immunosuppressive drugs in HLA matched and mismatched patients after living donor kidney and hematopoietic cell transplantation, Am J Transplant, vol.15, p.25693475, 2015.

S. Heidt, J. Hester, S. Shankar, P. J. Friend, and K. J. Wood, B-Cell Repopulation After Alemtuzumab InductionTransient Increase in Transitional B cells and Long-Term Dominance of Naive B Cells, Am J Transplant, 2012.