, Extraction and precipitation of DNA, Cold Spring Harbor Protoc, vol.3, pp.5-6, 2006.

F. Abaitua, M. Hollinshead, M. Bolstad, C. M. Crump, and P. Hare, A Nuclear localization signal in herpesvirus protein VP1-2 is essential for infection via capsid routing to the nuclear pore, J. Virol, vol.86, pp.8998-9014, 2012.

N. Abeyrathna, K. Washington, C. Bashur, and Y. Liao, Nonmetallic carbon monoxide releasing molecules (CORMs), Org Biomol. Chem, 2017.
DOI : 10.1039/c7ob01674c

T. Akaike and H. Maeda, Nitric oxide and virus infection, Immunology, vol.101, pp.300-308, 2000.

A. S. Almeida, C. Figueiredo-pereira, and H. L. Vieira, Carbon monoxide and mitochondria-modulation of cell metabolism, redox response and cell death, Front. Physiol, vol.6, p.33, 2015.

J. Boczkowski, J. J. Poderoso, and R. Motterlini, CO-metal interaction: vital signaling from a lethal gas, Trends Biochem. Sci, vol.31, pp.614-621, 2006.

H. L. Bonkovsky, J. F. Healey, and J. Pohl, Purification and characterization of heme oxygenase from chick liver. Comparison of the avian and mammalian enzymes, Eur. J. Biochem, vol.189, pp.155-166, 1990.

S. L. Camhi, J. Alam, L. Otterbein, S. L. Sylvester, and A. M. Choi, Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation, Am. J. Respir. Cell Mol. Biol, vol.13, pp.387-398, 1995.

X. Chen, H. Qiao, T. Liu, Z. Yang, L. Xu et al., Inhibition of herpes simplex virus infection by oligomeric stilbenoids through ROS generation, Antiviral Res, vol.95, pp.30-36, 2012.

N. Cheshenko, J. B. Trepanier, M. Stefanidou, N. Buckley, P. Gonzalez et al., HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression, FASEB J, vol.27, pp.2584-2599, 2013.

B. M. Choi, H. O. Pae, Y. R. Jeong, G. S. Oh, C. D. Jun et al., Overexpression of heme oxygenase (HO)-1 renders Jurkat T cells resistant to fas-mediated apoptosis: involvement of iron released by HO-1. Free Radic, Biol. Med, vol.36, pp.858-871, 2004.

J. E. Clark, R. Foresti, C. J. Green, and R. Motterlini, Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress, Biochem J, vol.15, pp.615-619, 2000.

K. D. Croen, Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication, J. Clin. Invest, vol.91, pp.2446-2452, 1993.

M. G. Delboy, D. G. Roller, N. , and A. V. , Cellular proteasome activity facilitates herpes simplex virus entry at a postpenetration step, J. Virol, vol.82, pp.3381-3390, 2008.

M. Desmard, J. Boczkowski, J. Poderoso, and R. Motterlini, Mitochondrial and cellular heme-dependent proteins as targets for the bioactive function of the heme oxygenase/carbon monoxide system, Antioxid. Redox Signal, vol.9, pp.2139-2155, 2007.

K. Devadas and S. Dhawan, Hemin activation ameliorates HIV-1 infection via heme oxygenase-1 induction, J. Immunol, vol.176, pp.4252-4257, 2006.
DOI : 10.4049/jimmunol.176.7.4252
URL : http://www.jimmunol.org/content/176/7/4252.full.pdf

E. M. Dioum, J. Rutter, J. R. Tuckerman, G. Gonzalez, M. A. Gilles-gonzalez et al., NPAS2: a gas-responsive transcription factor, Science, vol.298, pp.2385-2387, 2002.
DOI : 10.1126/science.1078456

M. P. Dodding, W. , and M. , Coupling viruses to dynein and kinesin-1, EMBO J, vol.30, pp.3527-3539, 2011.
DOI : 10.1038/emboj.2011.283
URL : http://emboj.embopress.org/content/embojnl/30/17/3527.full.pdf

A. Dolan, F. E. Jamieson, C. Cunningham, B. C. Barnett, and D. J. Mcgeoch, The genome sequence of herpes simplex virus type 2, J. Virol, vol.72, pp.2010-2021, 1998.

R. S. Eisenstein, D. Garcia-mayol, W. Pettingell, and H. N. Munro, Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron, Proc. Natl. Acad. Sci. U.S.A, vol.88, pp.688-692, 1991.

J. A. Espinoza, M. A. Leon, P. F. Cespedes, R. S. Gomez, G. Canedo-marroquin et al., Heme oxygenase-1 modulates human respiratory syncytial virus replication and lung pathogenesis during infection, Proc. Natl. Acad. Sci. U.S.A, vol.199, pp.212-223, 2017.
DOI : 10.4049/jimmunol.1601414
URL : http://www.jimmunol.org/content/jimmunol/199/1/212.full.pdf

P. Ewing, A. Wilke, G. Eissner, E. Holler, R. Andreesen et al., Expression of heme oxygenase-1 protects endothelial cells from irradiationinduced apoptosis, Endothelium, vol.12, pp.113-119, 2005.

C. Fillebeen, A. M. Rivas-estilla, M. Bisaillon, P. Ponka, M. Muckenthaler et al., Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C virus, J. Biol. Chem, vol.280, pp.9049-9057, 2005.

G. Gueron, J. Giudice, P. Valacco, A. Paez, B. Elguero et al., Heme-oxygenase-1 implications in cell morphology and the adhesive behavior of prostate cancer cells, Oncotarget, vol.5, pp.4087-4102, 2014.

T. Hashiba, M. Suzuki, Y. Nagashima, S. Suzuki, S. Inoue et al., Adenovirus-mediated transfer of heme oxygenase-1 cDNA attenuates severe lung injury induced by the influenza virus in mice, Gene Ther, vol.8, pp.1499-1507, 2001.

L. Hill-batorski, P. Halfmann, G. Neumann, and Y. Kawaoka, The cytoprotective enzyme heme oxygenase-1 suppresses Ebola virus replication, J. Virol, vol.87, pp.13795-13802, 2013.

P. Kaczara, R. Motterlini, G. M. Rosen, B. Augustynek, P. Bednarczyk et al., Carbon monoxide released by CORM-401 uncouples mitochondrial respiration and inhibits glycolysis in endothelial cells, A role for mitoBKCa channels, Biochim. Biophys. Acta, vol.1847, pp.1297-1309, 2015.

J. Kapitulnik, Bilirubin: an endogenous product of heme degradation with both cytotoxic and cytoprotective properties, Mol. Pharmacol, vol.66, pp.773-779, 2004.

S. M. Keyse and R. M. Tyrrell, Both near ultraviolet radiation and the oxidizing agent hydrogen peroxide induce a 32-kDa stress protein in normal human skin fibroblasts, J. Biol. Chem, vol.262, pp.14821-14825, 1987.

S. M. Keyse and R. M. Tyrrell, Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite, Proc. Natl. Acad. Sci. U.S.A, vol.86, pp.99-103, 1989.

H. P. Kim, X. Wang, F. Galbiati, S. W. Ryter, and A. M. Choi, Caveolae compartmentalization of heme oxygenase-1 in endothelial cells, FASEB J, vol.18, pp.1080-1089, 2004.

M. Lavitrano, R. T. Smolenski, A. Musumeci, M. Maccherini, E. Slominska et al., Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs, FASEB J, vol.18, pp.1093-1095, 2004.

G. E. Lee, J. W. Murray, A. W. Wolkoff, and D. W. Wilson, Reconstitution of herpes simplex virus microtubule-dependent trafficking in vitro, J. Virol, vol.80, pp.4264-4275, 2006.

W. Y. Lee, Y. C. Chen, C. M. Shih, C. M. Lin, C. H. Cheng et al., The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide, Toxicol. Appl. Pharmacol, vol.274, pp.55-62, 2014.

E. Lehmann, W. H. El-tantawy, M. Ocker, R. Bartenschlager, V. Lohmann et al., The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response, Hepatology, vol.51, pp.398-404, 2010.

Q. Lin, S. Weis, G. Yang, Y. H. Weng, R. Helston et al., , 2007.

, Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress, J. Biol. Chem, vol.282, pp.20621-20633

X. M. Liu, Z. E. Durante, K. J. Peyton, D. , and W. , Heme oxygenase-1-derived bilirubin counteracts HIV protease inhibitormediated endothelial cell dysfunction. Free Radic, Biol. Med, vol.94, pp.218-229, 2016.
DOI : 10.1016/j.freeradbiomed.2016.03.003
URL : http://europepmc.org/articles/pmc4844824?pdf=render

J. P. Mackern-oberti, J. Obreque, G. P. Mendez, C. Llanos, and A. M. Kalergis, Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus, Clin. Exp. Immunol, vol.182, pp.1-13, 2015.
URL : https://hal.archives-ouvertes.fr/inserm-02146926

M. D. Maines and A. Kappas, Enzymatic oxidation of cobalt protoporphyrin IX: observations on the mechanism of heme oxygenase action, Biochemistry, vol.16, pp.419-423, 1977.

J. D. Matthews, R. Morgan, C. Sleigher, and T. K. Frey, Do viruses require the cytoskeleton?, Virol. J, vol.10, p.121, 2013.

R. A. Mccloy, S. Rogers, C. E. Caldon, T. Lorca, A. Castro et al., Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events, Cell Cycle, vol.13, pp.1400-1412, 2014.

M. Menken, J. G. Waggoner, and N. I. Berlin, The influence of bilirubin on oxidative phosphorylation and related reactions in brain and liver mitochondria: effects of protein-binding, J. Neurochem, vol.13, pp.1241-1248, 1966.

R. Motterlini and L. E. Otterbein, The therapeutic potential of carbon monoxide, Nat. Rev. Drug Discov, vol.9, pp.728-743, 2010.

B. J. Murphy, K. R. Laderoute, S. M. Short, and R. M. Sutherland, The identification of heme oxygenase as a major hypoxic stress protein in Chinese hamster ovary cells, Br. J. Cancer, vol.64, pp.69-73, 1991.

W. W. Newcomb and J. C. Brown, Internal catalase protects herpes simplex virus from inactivation by hydrogen peroxide, J. Virol, vol.86, pp.11931-11934, 2012.

D. Olagnier, S. Peri, C. Steel, N. Van-montfoort, C. Chiang et al., Cellular oxidative stress response controls the antiviral and apoptotic programs in dengue virus-infected dendritic cells, PLoS Pathog, vol.10, p.1004566, 2014.

C. Peers, J. P. Boyle, J. L. Scragg, M. L. Dallas, M. M. Al-owais et al., Diverse mechanisms underlying the regulation of ion channels by carbon monoxide, Br. J. Pharmacol, vol.172, pp.1546-1556, 2015.

C. D. Petro, B. Weinrick, N. Khajoueinejad, C. Burn, R. Sellers et al., HSV-2 gD elicits Fc?R-effector antibodies that protect against clinical isolates, JCI insigth, vol.1, p.88529, 2016.

U. Protzer, S. Seyfried, M. Quasdorff, G. Sass, M. Svorcova et al., Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection, Gastroenterology, vol.133, pp.1156-1165, 2007.

S. A. Riquelme, S. M. Bueno, and A. M. Kalergis, Carbon monoxide down-modulates Toll-like receptor 4/MD2 expression on innate immune cells and reduces endotoxic shock susceptibility, Immunology, vol.144, pp.321-332, 2015.
URL : https://hal.archives-ouvertes.fr/inserm-02149644

S. A. Riquelme, J. Pogu, I. Anegon, S. M. Bueno, and A. M. Kalergis, Carbon monoxide impairs mitochondria-dependent endosomal maturation and antigen presentation in dendritic cells, Eur. J. Immunol, vol.45, pp.3269-3288, 2015.
URL : https://hal.archives-ouvertes.fr/inserm-02148083

S. W. Ryter, J. Alam, and A. M. Choi, Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications, Physiol. Rev, vol.86, pp.583-650, 2006.

R. Santangelo, C. Mancuso, S. Marchetti, E. Di-stasio, G. Pani et al., Bilirubin: an endogenous molecule with antiviral activity in vitro, Front. Pharmacol, vol.3, p.36, 2012.

M. K. Sardana and A. Kappas, Dual control mechanism for heme oxygenase: tin(IV)-protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver, Proc. Natl. Acad. Sci. U.S.A, vol.84, pp.2464-2468, 1987.

U. Schatzschneider, Novel lead structures and activation mechanisms for CO-releasing molecules (CORMs), Br. J. Pharmacol, vol.172, pp.1638-1650, 2015.

W. N. Schmidt, M. M. Mathahs, and Z. Zhu, Heme and HO-1 Inhibition of HCV, HBV, and HIV, Front. Pharmacol, vol.3, p.129, 2012.

Y. Shan, J. Pepe, T. H. Lu, K. K. Elbirt, R. W. Lambrecht et al., Induction of the heme oxygenase-1 gene by metalloporphyrins, Arch. Biochem. Biophys, vol.380, pp.219-227, 2000.

S. Shibahara, R. M. Muller, and H. Taguchi, Transcriptional control of rat heme oxygenase by heat shock, J. Biol. Chem, vol.262, pp.12889-12892, 1987.

D. J. Slebos, S. W. Ryter, M. Van-der-toorn, F. Liu, F. Guo et al., Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death, Am. J. Respir. Cell Mol. Biol, vol.36, pp.409-417, 2007.

P. A. Suazo, E. I. Tognarelli, A. M. Kalergis, and P. A. Gonzalez, , 2015.

, Herpes simplex virus 2 infection: molecular association with HIV and novel microbicides to prevent disease, Med. Microbiol. Immunol, vol.204, pp.161-176

V. Tardif, S. A. Riquelme, S. Remy, L. J. Carreno, C. M. Cortes et al., Carbon monoxide decreases endosome-lysosome fusion and inhibits soluble antigen presentation by dendritic cells to T cells, Eur. J. Immunol, vol.43, pp.2832-2844, 2013.

R. Tenhunen, M. E. Ross, H. S. Marver, and R. Schmid, Reduced nicotinamide-adenine dinucleotide phosphate dependent biliverdin reductase: partial purification and characterization, Biochemistry, vol.9, pp.298-303, 1970.
DOI : 10.1021/bi00804a016

C. M. Terry, J. A. Clikeman, J. R. Hoidal, and K. S. Callahan, Effect of tumor necrosis factor-? and interleukin-1 ? on heme oxygenase-1 expression in human endothelial cells, Am. J. Physiol, vol.274, pp.883-891, 1998.

C. K. Tseng, C. K. Lin, Y. H. Wu, Y. H. Chen, W. C. Chen et al., Human heme oxygenase 1 is a potential host cell factor against dengue virus replication, Sci. Rep, vol.6, p.32176, 2016.

T. Y. Tsui, A. Obed, Y. T. Siu, S. F. Yet, L. Prantl et al., Carbon monoxide inhalation rescues mice from fulminant hepatitis through improving hepatic energy metabolism, Shock, vol.27, pp.165-171, 2007.
DOI : 10.1097/01.shk.0000239781.71516.61

W. H. Tung, H. L. Hsieh, I. T. Lee, Y. , and C. M. , Enterovirus 71 induces integrin beta1/EGFR-Rac1-dependent oxidative stress in SK-N-SH cells: role of HO-1/CO in viral replication, J. Cell. Physiol, vol.226, pp.3316-3329, 2011.

G. F. Vile, S. Basu-modak, C. Waltner, and R. M. Tyrrell, Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts, Proc. Natl. Acad. Sci. U.S.A, vol.91, pp.2607-2610, 1994.

K. Wang, J. D. Kappel, C. Canders, W. F. Davila, D. Sayre et al., A herpes simplex virus 2 glycoprotein D mutant generated by bacterial artificial chromosome mutagenesis is severely impaired for infecting neuronal cells and infects only Vero cells expressing exogenous HVEM, J. Virol, vol.86, pp.12891-12902, 2012.
DOI : 10.1128/jvi.01055-12
URL : https://jvi.asm.org/content/86/23/12891.full.pdf

B. Wegiel, D. J. Gallo, K. G. Raman, J. M. Karlsson, B. Ozanich et al., Nitric oxide-dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury, Circulation, vol.121, pp.537-548, 2010.

A. Wolfstein, C. H. Nagel, K. Radtke, K. Dohner, V. J. Allan et al., The inner tegument promotes herpes simplex virus capsid motility along microtubules in vitro, Traffic, vol.7, pp.227-237, 2006.
DOI : 10.1111/j.1600-0854.2005.00379.x
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0854.2005.00379.x

S. Xiao, A. Zhang, C. Zhang, H. Ni, J. Gao et al., Heme oxygenase-1 acts as an antiviral factor for porcine reproductive and respiratory syndrome virus infection and over-expression inhibits virus replication in vitro, Antiviral Res, vol.110, pp.60-69, 2014.

T. Yoshida, P. Biro, T. Cohen, R. M. Muller, and S. Shibahara, Human heme oxygenase cDNA and induction of its mRNA by hemin, Eur. J. Biochem, vol.171, pp.457-461, 1988.

A. Zhang, L. Zhao, N. Li, H. Duan, H. Liu et al., Carbon monoxide inhibits porcine reproductive and respiratory syndrome virus replication by the cyclic GMP/protein kinase G and NF-kappaB signaling pathway, J. Virol, vol.91, pp.1866-1882, 2017.

C. Zhang, F. Pu, A. Zhang, L. Xu, N. Li et al., Heme oxygenase-1 suppresses bovine viral diarrhoea virus replication in vitro, Sci. Rep, vol.5, p.15575, 2015.

M. Zhong, K. Zheng, M. Chen, Y. Xiang, F. Jin et al., Heat-shock protein 90 promotes nuclear transport of herpes simplex virus 1 capsid protein by interacting with acetylated tubulin, PLoS ONE, vol.9, p.99425, 2014.

Z. Zhu, A. T. Wilson, B. A. Luxon, K. E. Brown, M. M. Mathahs et al., Biliverdin inhibits hepatitis C virus nonstructural 3/4A protease activity: mechanism for the antiviral effects of heme oxygenase?, Hepatology, vol.52, pp.1897-1905, 2010.

F. Zobi, CO and CO-releasing molecules in medicinal chemistry, Future Med. Chem, vol.5, pp.175-188, 2013.

B. S. Zuckerbraun, T. R. Billiar, S. L. Otterbein, P. K. Kim, F. Liu et al., Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1, J. Exp. Med, vol.198, pp.1707-1716, 2003.

B. S. Zuckerbraun, B. Y. Chin, M. Bilban, J. C. Avila, J. Rao et al., Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species, FASEB J, vol.21, pp.1099-1106, 2007.