Herpes simplex virus type 2: epidemiology and management options in developing countries, Sex Transm Infect, vol.83, issue.1, pp.16-22, 2007. ,
Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review, J Infect Dis, issue.1, p.186, 2002. ,
Global and regional estimates of prevalent and incident herpes simplex virus type 1 infections in 2012, PLoS One, vol.10, issue.10, p.140765, 2015. ,
The acquisition of herpes simplex virus during pregnancy, N Engl J Med, vol.337, issue.8, pp.509-524, 1997. ,
Herpes simplex serious neurological disease in young children: incidence and long-term outcome, Arch Dis Child, vol.97, issue.2, pp.162-167, 2012. ,
Update on herpes virus infections of the nervous system, Curr Neurol Neurosci Rep, vol.13, issue.12, p.414, 2013. ,
Synergistic copathogens -HIV-1 and HSV-2, N Engl J Med, vol.356, issue.8, pp.854-860, 2007. ,
DOI : 10.1056/nejme068302
Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2, N Engl J Med, vol.362, issue.5, pp.427-466, 2010. ,
Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies, AIDS, vol.20, issue.1, pp.73-83, 2006. ,
Herpes simplex virus 2 infection: molecular association with HIV and novel microbicides to prevent disease, Med Microbiol Immunol, vol.204, issue.2, pp.161-76, 2015. ,
Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis, J Infect Dis, vol.185, issue.1, pp.45-52, 2002. ,
Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials, Lancet, vol.379, issue.9816, pp.61750-61759, 2012. ,
Acyclovir: a decade later, N Engl J Med, vol.327, issue.11, pp.782-791, 1992. ,
Generating protective immunity against genital herpes, Trends Immunol, vol.34, issue.10, pp.487-94, 2013. ,
Status of prophylactic and therapeutic genital herpes vaccines, Curr Opin Virol, vol.6, pp.6-12, 2014. ,
Safety and immunogenicity of glycoprotein D-adjuvant genital herpes vaccine, Clin Infect Dis, vol.40, issue.9, pp.1271-81, 2005. ,
HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression, FASEB J, vol.27, issue.7, pp.2584-99, 2013. ,
Herpesviruses remodel host membranes for virus egress, Nat Rev Microbiol, vol.9, issue.5, pp.382-94, 2011. ,
Early events in herpes simplex virus lifecycle with implications for an infection of lifetime, Open Virol J, vol.6, pp.1-6, 2012. ,
Structurefunction analysis of soluble forms of herpes simplex virus glycoprotein D, J Virol, vol.70, issue.6, pp.3815-3837, 1996. ,
Dissection of the antibody response against herpes simplex virus glycoproteins in naturally infected humans, J Virol, vol.88, issue.21, pp.12612-12634, 2014. ,
Efficacy results of a trial of a herpes simplex vaccine, N Engl J Med, vol.366, issue.1, pp.34-43, 2012. ,
Recombinant glycoprotein vaccine for the prevention of genital HSV-2 infection: two randomized controlled trials. Chiron HSV Vaccine Study Group, JAMA, vol.282, issue.4, pp.331-371, 1999. ,
Limited antibody-dependent cellular cytotoxicity antibody response induced by a herpes simplex virus type 2 subunit vaccine, J Infect Dis, vol.181, issue.1, pp.335-344, 2000. ,
DOI : 10.1086/315208
URL : https://academic.oup.com/jid/article-pdf/181/1/335/17995701/181-1-335.pdf
Double-blind, placebo-controlled trial of a herpes simplex virus type 2 glycoprotein vaccine in persons at high risk for genital herpes infection, J Infect Dis, vol.161, issue.4, pp.653-60, 1990. ,
HSV-2 vaccine: current status and insight into factors for developing an efficient vaccine, Viruses, vol.6, issue.2, pp.371-90, 2014. ,
Immune evasion by herpes simplex viruses, Rev Chil Infectol, vol.32, issue.1, pp.58-70, 2015. ,
Patient-specific neutralizing antibody responses to herpes simplex virus are attributed to epitopes on gD, gB, or both and can be type specific, J Virol, vol.89, issue.18, pp.9213-9244, 2015. ,
Immune evasion by herpes simplex viruses, herpesviridae, pp.105-151, 2016. ,
Clinical and molecular aspects of the live attenuated Oka varicella vaccine, Rev Med Virol, vol.24, issue.4, pp.254-73, 2014. ,
Molecular studies of the Oka varicella vaccine, Expert Rev Vaccines, vol.10, issue.9, pp.1321-1357, 2011. ,
Global varicella vaccine effectiveness: a meta-analysis, Pediatrics, vol.137, issue.3, p.20153741, 2016. ,
The herpes zoster subunit vaccine, Expert Opin Biol Ther, vol.16, issue.2, pp.265-71, 2016. ,
A live-attenuated HSV-2 ICP0 virus elicits 10 to 100 times greater protection against genital herpes than a glycoprotein D subunit vaccine, PLoS One, vol.6, issue.3, p.17748, 2011. ,
DOI : 10.1371/journal.pone.0017748
Antibodies are required for complete vaccine-induced protection against herpes simplex virus 2, PLoS One, vol.10, issue.12, p.145228, 2015. ,
DOI : 10.1371/journal.pone.0145228
Herpes simplex virus 2 (HSV-2) infected cell proteins are among the most dominant antigens of a live-attenuated HSV-2 vaccine, PLoS One, vol.10, issue.2, p.116091, 2015. ,
Construction, phenotypic analysis, and immunogenicity of a UL5/UL29 double deletion mutant of herpes simplex virus 2, J Virol, vol.74, issue.17, pp.7963-71, 2000. ,
High-purity preparation of HSV-2 vaccine candidate ACAM529 is immunogenic and efficacious in vivo, PLoS One, vol.8, issue.2, p.57224, 2013. ,
Protection from genital herpes disease, seroconversion and latent infection in a non-lethal murine genital infection model by immunization with an HSV-2 replication-defective mutant virus, Virology, vol.488, pp.61-68, 2016. ,
A double-blind study of the efficacy and safety of the ICP10PK vaccine against recurrent genital HSV-2 infections, Cutis, 2002. ,
Vaccine potential of a herpes simplex virus type 2 mutant deleted in the PK domain of the large subunit of ribonucleotide reductase (ICP10), Vaccine, vol.17, pp.470-478, 1999. ,
Development of HSV-specific CD4+ Th1 responses and CD8+ cytotoxic T lymphocytes with antiviral activity by vaccination with the HSV-2 mutant ICP10DeltaPK, Vaccine, pp.2796-807, 2002. ,
A growth and latency compromised herpes simplex virus type 2 mutant (ICP10DeltaPK) has prophylactic and therapeutic protective activity in guinea pigs, Vaccine, vol.19, pp.1879-90, 2001. ,
A herpes simplex virus 2 (HSV-2) gD mutant impaired for neural tropism is superior to an HSV-2 gD subunit vaccine to protect animals from challenge with HSV-2, J Virol, vol.90, issue.1, pp.562-74, 2015. ,
Live attenuated herpes simplex virus 2 glycoprotein E deletion mutant as a vaccine candidate defective in neuronal spread, J Virol, vol.86, issue.8, pp.4586-98, 2012. ,
Vaccination of rhesus macaques with the live-attenuated HSV-1 vaccine VC2 stimulates the proliferation of mucosal T cells and germinal center responses resulting in sustained production of highly neutralizing antibodies, vol.35, pp.536-579, 2017. ,
Evaluation of AD472, a live attenuated recombinant herpes simplex virus type 2 vaccine in guinea pigs, Vaccine, vol.23, pp.5424-5455, 2005. ,
Evaluation of a live attenuated recombinant virus RAV 9395 as a herpes simplex virus type 2 vaccine in guinea pigs, J Infect Dis, vol.177, issue.5, pp.1143-54, 1998. ,
Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease, Elife, vol.4, p.6054, 2015. ,
HSV-2 DeltagD elicits FcgammaR-effector antibodies that protect against clinical isolates, JCI Insight, vol.1, issue.12, p.88529, 2016. ,
DOI : 10.1172/jci.insight.88529
URL : http://insight.jci.org/articles/view/88529/files/pdf
Immunity in the female genital tract after intravaginal vaccination of mice with an attenuated strain of herpes simplex virus type 2, J Virol, vol.51, issue.3, pp.747-53, 1984. ,
A vaccine strategy that protects against genital herpes by establishing local memory T cells, Nature, vol.491, issue.7424, pp.463-470, 2012. ,
A genetically inactivated herpes simplex virus type 2 (HSV-2) vaccine provides effective protection against primary and recurrent HSV-2 disease, J Infect Dis, vol.175, issue.1, pp.16-25, 1997. ,
A randomized controlled trial of a replication defective (gH deletion) herpes simplex virus vaccine for the treatment of recurrent genital herpes among immunocompetent subjects, Vaccine, vol.24, issue.7, pp.914-934, 2006. ,
Immunization against genital herpes with a vaccine virus that has defects in productive and latent infection, Proc Natl Acad Sci U S A, vol.96, issue.12, pp.6994-7002, 1999. ,
Comparative efficacy and immunogenicity of replication-defective, recombinant glycoprotein, and DNA vaccines for herpes simplex virus 2 infections in mice and guinea pigs, J Virol, vol.79, issue.1, pp.410-418, 2005. ,
Herpes simplex virus 2 ICP0 mutant viruses are avirulent and immunogenic: implications for a genital herpes vaccine, PLoS One, vol.5, issue.8, p.12251, 2010. ,
Herpes simplex virus type 1 glycoprotein D inhibits T-cell proliferation, Mol Cells, vol.14, issue.3, pp.398-403, 2002. ,
The Us3 protein of herpes simplex virus 1 inhibits T cell signaling by confining linker for activation of T cells (LAT) activation via TRAF6 protein, J Biol Chem, issue.25, pp.15670-15678, 2015. ,
Inhibition of TCR signaling by herpes simplex virus, J Immunol, vol.176, issue.3, pp.1825-1858, 2006. ,
Caspase 9 is essential for herpes simplex virus type 2-induced apoptosis in T cells, J Virol, vol.84, issue.6, pp.3116-3136, 2010. ,
Modulation of CD112 by the alphaherpesvirus gD protein suppresses DNAM-1-dependent NK cell-mediated lysis of infected cells, Proc Natl Acad Sci U S A, vol.111, issue.45, pp.16118-16141, 2014. ,
Immunobiology of dendritic cells, Annu Rev Immunol, vol.18, pp.767-811, 2000. ,
Dendritic cells and vaccine design for sexually-transmitted diseases, Microb Pathog, vol.58, pp.35-44, 2013. ,
Cell biology of antigen processing in vitro and in vivo, Annu Rev Immunol, vol.23, pp.975-1028, 2005. ,
Dendritic cells: translating innate to adaptive immunity, Curr Top Microbiol Immunol, vol.311, pp.17-58, 2006. ,
DOI : 10.1007/3-540-32636-7_2
URL : http://bilder.buecher.de/zusatz/20/20793/20793145_lese_1.pdf
Modulation of immunological synapse by membrane-bound and soluble ligands, Cytokine Growth Factor Rev, vol.18, issue.1-2, pp.19-31, 2007. ,
T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases, Nature, vol.427, issue.6970, pp.154-163, 2004. ,
Mechanisms used by virulent Salmonella to impair dendritic cell function and evade adaptive immunity, Immunology, vol.137, issue.1, pp.28-36, 2012. ,
Human cytomegalovirus inhibits maturation and impairs function of monocyte-derived dendritic cells, Blood, issue.8, pp.2913-2934, 2002. ,
Respiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cells, Proc Natl Acad Sci U S A, issue.39, pp.14999-5004, 2008. ,
Herpes simplex virus 2 (HSV-2) prevents dendritic cell maturation, induces apoptosis, and triggers release of proinflammatory cytokines: potential links to HSV-HIV synergy, J Virol, vol.87, issue.3, pp.1443-53, 2013. ,
CD1 antigen presentation by human dendritic cells as a target for herpes simplex virus immune evasion, J Immunol, vol.177, issue.9, p.6207, 2006. ,
Herpes simplex virus gamma34.5 interferes with autophagosome maturation and antigen presentation in dendritic cells, MBio, vol.3, issue.5, pp.267-212, 2012. ,
HSV-2 specifically down regulates HLA-C expression to render HSV-2-infected DCs susceptible to NK cell killing, PLoS Pathog, vol.9, issue.3, p.1003226, 2013. ,
Herpes simplex virus infects skin gamma delta T cells before Langerhans cells and impedes migration of infected Langerhans cells by inducing apoptosis and blocking E-cadherin downregulation, J Immunol, issue.1, pp.477-87, 2010. ,
Herpes simplex virus turns off the TAP to evade host immunity, Nature, vol.375, issue.6530, pp.411-416, 1995. ,
Herpes simplex virus infection of human dendritic cells induces apoptosis and allows cross-presentation via uninfected dendritic cells, J Immunol, vol.174, issue.4, pp.2220-2227, 2005. ,
Herpes simplex virus 1 suppresses the function of lung dendritic cells via caveolin-1, Clin Vaccine Immunol, vol.22, issue.8, pp.883-95, 2015. ,
Herpes simplex virus type 2 induces rapid cell death and functional impairment of murine dendritic cells in vitro, J Virol, vol.77, pp.11139-11188, 1920. ,
An engineered herpesvirus activates dendritic cells and induces protective immunity, vol.7, p.41461, 2017. ,
DOI : 10.1038/srep41461
URL : https://www.nature.com/articles/srep41461.pdf
The genome sequence of herpes simplex virus type 2, J Virol, vol.72, issue.3, pp.2010-2031, 1998. ,
Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses, PLoS One, vol.9, issue.1, p.87617, 2014. ,
Glycoproteindependent and TLR2-independent innate immune recognition of herpes simplex virus-1 by dendritic cells, J Immunol, vol.180, issue.11, pp.7525-7561, 2008. ,
The dendritic cell side of the immunological synapse, Biomol Concepts, vol.7, issue.1, pp.17-28, 2016. ,
Reactive oxygen species level defines two functionally distinctive stages of inflammatory dendritic cell development from mouse bone marrow, J Immunol, issue.6, pp.2863-72, 2010. ,
Functional T cell recognition of synthetic peptides corresponding to continuous antibody epitopes of herpes simplex virus type 1 glycoprotein D, Immunobiology, vol.177, issue.2, pp.134-182, 1988. ,
Identification of novel virus-specific antigens by CD4(+) and CD8(+) T cells from asymptomatic HSV-2 seropositive and seronegative donors, Virology, vol.46, pp.296-311, 2014. ,
Therapeutic immunization with a mixture of herpes simplex virus 1 glycoprotein D-derived "asymptomatic" human CD8+ T-cell epitopes decreases spontaneous ocular shedding in latently infected HLA transgenic rabbits: association with low frequency of local PD-1+ TIM-3+ CD8+ exhausted T cells, J Virol, vol.89, issue.13, pp.6619-6651, 2015. ,
Herpes simplex virus type 2 tegument proteins contain subdominant T-cell epitopes detectable in BALB/c mice after DNA immunization and infection, J Gen Virol, pp.1153-63, 2009. ,
Defining the herpes simplex virus-specific CD8+ T cell repertoire in C57BL/6 mice, J Immunol, vol.186, issue.7, pp.3927-3960, 2011. ,
CD8+ T lymphocyte epitopes from the herpes simplex virus type 2 ICP27, VP22 and VP13/14 proteins to facilitate vaccine design and characterization, Cells, vol.2, issue.1, pp.19-42, 2013. ,
Immunomodulatory effects of HSV-2 infection on immature macaque dendritic cells modify innate and adaptive responses, Blood, vol.106, issue.4, pp.1305-1318, 2005. ,
OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells, Immunity, vol.15, issue.3, pp.445-55, 2001. ,
OX40 ligation enhances cell cycle turnover of Ag-activated CD4 T cells in vivo, Cell Immunol, vol.209, issue.1, pp.63-75, 2001. ,
CD28 and T cell co-stimulation, Rev Immunogenet, vol.2, issue.2, pp.175-84, 2000. ,
Loss of CD28 expression on CD8(+) T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis, Int Immunol, vol.12, issue.7, pp.1005-1018, 2000. ,
Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells, Int Immunol, vol.19, issue.12, pp.1383-94, 2007. ,
Characterization of two TCR transgenic mouse lines specific for herpes simplex virus, Immunol Cell Biol, vol.80, issue.2, pp.156-63, 2002. ,
Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells, Nat Immunol, vol.10, issue.5, pp.488-95, 2009. ,
Relay of herpes simplex virus between Langerhans cells and dermal dendritic cells in human skin, PLoS Pathog, vol.11, issue.4, p.1004812, 2015. ,
Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2, J Exp Med, vol.197, issue.2, pp.153-62, 2003. ,
A CFSE-based assay to study the migration of murine skin dendritic cells into draining lymph nodes during infection with Mycobacterium bovis bacille Calmette-Guérin, J Vis Exp, issue.116, 2016. ,
Spatiotemporally distinct interactions with dendritic cell subsets facilitates CD4+ and CD8+ T cell activation to localized viral infection, Immunity, vol.43, issue.3, pp.554-65, 2015. ,
Bone marrow-derived cells expand memory CD8+ T cells in response to viral infections of the lung and skin, Eur J Immunol, vol.36, issue.2, pp.327-362, 2006. ,
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow, J Immunol Methods, vol.223, issue.1, pp.77-92, 1999. ,
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor, J Exp Med, vol.176, issue.6, pp.1693-702, 1992. ,
Purification of splenic dendritic cells induces maturation and capacity to stimulate Th1 response in vivo, Int Immunol, vol.18, issue.3, pp.445-52, 2006. ,
Depending on their maturation state, splenic dendritic cells induce the differentiation of CD4(+) T lymphocytes into memory and/or effector cells in vivo, Eur J Immunol, vol.34, issue.7, pp.1861-1870, 2004. ,
Expression of Cathepsin S in BCG converts it into a pro-apoptotic and highly immunogenic strain, vol.35, pp.2060-2068, 2017. ,
A novel recombinant BCG-expressing pro-apoptotic protein BAX enhances Th1 protective immune responses in mice, Mol Immunol, vol.66, issue.2, pp.346-56, 2015. ,
Deletion of nuoG from the vaccine candidate Mycobacterium bovis BCG DeltaureC:hly improves protection against tuberculosis, MBio, vol.7, issue.3, pp.679-616, 2016. ,