Tissue microstructure information from T2 relaxometry and diffusion MRI can identify multiple sclerosis (MS) lesions undergoing blood-brain barrier breakdown (BBB)

Sudhanya Chatterjee 1 Olivier Commowick 1 Onur Afacan 2 Simon Warfield 2 Christian Barillot 1
1 Empenn
INSERM - Institut National de la Santé et de la Recherche Médicale, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
2 CRL - Computational Radiology Laboratory [Boston]
Abstract : Gadolinium based contrast agents (GBCA) play a critical role in identifying MS lesions undergoing BBB which is of high clinical importance. However, repeated use of GBCAs over a long period of time and the risks associated with administering it to patients with renal complications has mandated for greater caution in its usage. In this work we explored the plausibility of identifying MS lesions undergoing BBB from tissue microstructure information obtained from T2 relaxometry and dMRI data. We also proposed a framework to predict MS lesions undergoing BBB using the tissue microstructure information and demonstrated its potential on a test case.
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https://www.hal.inserm.fr/inserm-02153311
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Submitted on : Wednesday, June 12, 2019 - 10:25:41 AM
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Sudhanya Chatterjee, Olivier Commowick, Onur Afacan, Simon Warfield, Christian Barillot. Tissue microstructure information from T2 relaxometry and diffusion MRI can identify multiple sclerosis (MS) lesions undergoing blood-brain barrier breakdown (BBB). ISMRM 2019 - 27th Annual Meeting & Exhibition, May 2019, Montreal, Canada. pp.1-4. ⟨inserm-02153311⟩

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