Molecular Actions of PPARα in Lipid Metabolism and Inflammation

Abstract : Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor of clinical interest as a drug target in various metabolic disorders. PPARα also exhibits marked anti-inflammatory capacities. The first-generation PPARα agonists, the fibrates, have however been hampered by drug-drug interaction issues, statin drop-in, and ill-designed cardiovascular intervention trials. Notwithstanding, understanding the molecular mechanisms by which PPARα works will enable control of its activities as a drug target for metabolic diseases with an underlying inflammatory component. Given its role in reshaping the immune system, the full potential of this nuclear receptor subtype as a versatile drug target with high plasticity becomes increasingly clear, and a novel generation of agonists may pave the way for novel fields of applications.
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Nadia Bougarne, Basiel Weyers, Sofie Desmet, Julie Deckers, David Ray, et al.. Molecular Actions of PPARα in Lipid Metabolism and Inflammation. Endocrine reviews, Endocrine Society, 2018, 39 (5), pp.760-802. ⟨10.1210/er.2018-00064⟩. ⟨inserm-02153118⟩

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