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Journal Articles PeerJ Year : 2016

Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies

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Phillip Lord
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  • PersonId : 1048463

Abstract

Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promiseforthetreatmentofautoimmunediseasesandforthepreventionofdestructive immune responses after transplantation. The methodologies for generating tolAPC vary greatly between different laboratories, making it difficult to compare data from differentstudies;thusconstitutingamajorhurdleforthedevelopmentofstandardised tolAPCtherapeuticproducts.HerewedescribeaninitiativebymembersofthetolAPC field to generate a minimum information model for tolAPC (MITAP), providing a reporting framework that will make differences and similarities between tolAPC productstransparent.Inthisway,MITAPconstitutesafirstbutimportantsteptowards the production of standardised and reproducible tolAPC for clinical application.
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Dates and versions

inserm-02150722 , version 1 (07-06-2019)

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Phillip Lord, Rachel Spiering, Juan C Aguillon, Amy E Anderson, Silke Appel, et al.. Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies. PeerJ, 2016, 4, pp.e2300. ⟨10.7717/peerj.2300⟩. ⟨inserm-02150722⟩
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