Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies

Phillip Lord 1 Rachel Spiering 2 Juan Aguillon 3 Amy Anderson 2 Silke Appel 4 Daniel Benitez-Ribas 5 Anja ten Brinke 6 Femke Broere 7 Nathalie Cools 8 Maria Cuturi 9, 10 Julie Diboll 2 Edward Geissler 11 Nick Giannoukakis 12 Silvia Gregori 13 S Marieke van Ham 6 Staci Lattimer 1 Lindsay Marshall 1 Rachel Harry 2 James Hutchinson 11 John Isaacs 2 Irma Joosten 14 Cees van Kooten 15 Ascension Lopez Diaz de Cerio 16 Tatjana Nikolic 17 Haluk Barbaros Oral 18 Ljiljana Sofronic-Milosavljevic 19 Thomas Ritter 20 Paloma Riquelme 11 Angus Thomson 21 Massimo Trucco 12 Marta Vives-Pi 22, 23 Eva Martinez-Caceres 22, 24 Catharien M.U. Hilkens 2, *
* Corresponding author
Abstract : Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promiseforthetreatmentofautoimmunediseasesandforthepreventionofdestructive immune responses after transplantation. The methodologies for generating tolAPC vary greatly between different laboratories, making it difficult to compare data from differentstudies;thusconstitutingamajorhurdleforthedevelopmentofstandardised tolAPCtherapeuticproducts.HerewedescribeaninitiativebymembersofthetolAPC field to generate a minimum information model for tolAPC (MITAP), providing a reporting framework that will make differences and similarities between tolAPC productstransparent.Inthisway,MITAPconstitutesafirstbutimportantsteptowards the production of standardised and reproducible tolAPC for clinical application.
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Phillip Lord, Rachel Spiering, Juan Aguillon, Amy Anderson, Silke Appel, et al.. Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies. PeerJ, PeerJ, 2016, 4, pp.e2300. ⟨10.7717/peerj.2300⟩. ⟨inserm-02150722⟩

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