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Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies

Phillip Lord 1 Rachel Spiering 2 Juan C Aguillon 3 Amy E Anderson 2 Silke Appel 4 Daniel Benitez-Ribas 5 Anja ten Brinke 6 Femke Broere 7 Nathalie Cools 8 Maria Cristina Cuturi 9, 10 Julie Diboll 2 Edward K Geissler 11 Nick Giannoukakis 12 Silvia Gregori 13 S Marieke van Ham 6 Staci Lattimer 1 Lindsay Marshall 1 Rachel A Harry 2 James A Hutchinson 11 John D Isaacs 2 Irma Joosten 14 Cees van Kooten 15 Ascension Lopez Diaz de Cerio 16 Tatjana Nikolic 17 Haluk Barbaros Oral 18 Ljiljana Sofronic-Milosavljevic 19 Thomas Ritter 20 Paloma Riquelme 11 Angus W Thomson 21 Massimo Trucco 12 Marta Vives-Pi 22, 23 Eva M Martinez-Caceres 22, 24 Catharien M.U. Hilkens 2, * 
* Corresponding author
1 School of Computing Science [Newcastle]
2 Institute of Cellular Medicine [Newcastle]
3 Facultad de Medicina - Instituto de Ciencias Biomédicas [Santiago, Chile]
4 Department of Clinical Science - Broegelmann Research Laboratory [Bergen, Norway]
5 Department of Immunology [Barcelona, Spain]
6 Department of Immunopathology [Amsterdam, The Netherlands]
7 Department of Infectious Diseases and Immunology [Utrecht, The Netherlands]
8 Faculty of Medicine and Health Sciences - Laboratory of Experimental Hematology [Wilrijk, Belgium]
9 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie
10 ITUN - Institut de transplantation urologie-néphrologie
11 Department of Surgery, Section of Experimental Surgery [Regensburg, Germany]
12 Institute of Cellular Therapeutics [Pittsburgh, PA, USA]
13 Division of Regenerative Medicine, Stem Cells and Gene Therapy [Milan, Italy]
14 Department of Laboratory Medicine [Nijmegen, the Netherlands]
15 Department of Nephrology [Leiden, The Netherlands]
16 Area of Cell Therapy [Pamplona, Spain]
17 Department of Immunohematology and Blood Transfusion [Leiden, The Netherlands]
18 Faculty of Medicine - Department of Immunology [Bursa, Turkey]
19 INEP - Institute for the Application of Nuclear Energy [Belgrade, Serbia]
20 Regenerative Medicine Institute [Galway, Ireland]
21 Thomas E. Starzl Transplantation Institute [Pittsburgh, PA, USA]
22 Immunology Division [Badalona, Spain]
23 CIBERDEM - CIBER of Diabetes and Associated Metabolic Diseases [Madrid, Spain]
24 Department of Cellular Biology, Physiology and Immunology [Barcelona, Spain]
Abstract : Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promiseforthetreatmentofautoimmunediseasesandforthepreventionofdestructive immune responses after transplantation. The methodologies for generating tolAPC vary greatly between different laboratories, making it difficult to compare data from differentstudies;thusconstitutingamajorhurdleforthedevelopmentofstandardised tolAPCtherapeuticproducts.HerewedescribeaninitiativebymembersofthetolAPC field to generate a minimum information model for tolAPC (MITAP), providing a reporting framework that will make differences and similarities between tolAPC productstransparent.Inthisway,MITAPconstitutesafirstbutimportantsteptowards the production of standardised and reproducible tolAPC for clinical application.
Keywords : Celltherapy Minimuminformationmodel Antigen-presentingcells Autoimmune disease Transplantation Tolerogenicdendriticcells Regulatorymacrophages Reporting guidelines
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Phillip Lord, Rachel Spiering, Juan C Aguillon, Amy E Anderson, Silke Appel, et al.. Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies. PeerJ, PeerJ, 2016, 4, pp.e2300. ⟨10.7717/peerj.2300⟩. ⟨inserm-02150722⟩

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