S. Bahram, N. Mizuki, H. Inoko, and T. Spies, Nucleotide sequence of the human MHC class I MICA gene, Immunogenetics, vol.44, pp.80-81, 1996.

V. Groh, S. Bahram, S. Bauer, A. Herman, M. Beauchamp et al., Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium, Proc. Natl. Acad. Sci. USA, vol.93, pp.12445-12450, 1996.

N. W. Zwirner, M. A. Fernández-viña, and P. Stastny, MICA, a new polymorphic HLA-related antigen, is expressed mainly by keratinocytes, endothelial cells, and monocytes, Immunogenetics, vol.47, pp.139-148, 1998.

N. W. Zwirner, K. Dole, and P. Stastny, Differential surface expression of MICA by endothelial cells, fibroblasts, keratinocytes, and monocytes, Hum. Immunol, vol.60, pp.323-330, 1999.

S. Bauer, V. Groh, J. Wu, A. Steinle, J. H. Phillips et al., Activation of NK cells and T cells by NKG2D, a receptor for stressinducible MICA, Science, vol.285, pp.727-729, 1999.

D. H. Raulet, Roles of the NKG2D immunoreceptor and its ligands, Nat. Rev. Immunol, vol.3, pp.781-790, 2003.

K. Ogasawara and L. L. Lanier, NKG2D in NK and T cell-mediated immunity, J. Clin. Immunol, vol.25, pp.534-540, 2005.

S. González, A. López-soto, B. Suarez-alvarez, A. López-vázquez, and C. López-larrea, NKG2D ligands: key targets of the immune response, Trends Immunol, vol.29, pp.397-403, 2008.

S. Caillat-zucman, How NKG2D ligands trigger autoimmunity?, Hum. Immunol, vol.67, pp.204-207, 2006.

B. Suárez-alvarez, A. López-vázquez, J. M. Baltar, F. Ortega, and C. López-larrea, Potential role of NKG2D and its ligands in organ transplantation: new target for immunointervention, Am. J. Transplant, vol.9, pp.251-257, 2009.

M. U. Mondelli, NKG2D and its ligands: key to immunotherapy of liver cancer?, J. Hepatol, vol.56, pp.308-310, 2012.

H. A. Stephens, MICA and MICB genes: can the enigma of their polymorphism be resolved?, Trends Immunol, vol.22, pp.378-385, 2001.

S. Bahram, H. Inoko, T. Shiina, and M. Radosavljevic, MIC and other NKG2D ligands: from none to too many, Curr. Opin. Immunol, vol.17, pp.505-509, 2005.

K. G. Hankey, C. B. Drachenberg, J. C. Papadimitriou, D. K. Klassen, B. Philosophe et al., MIC expression in renal and pancreatic allografts, vol.73, pp.304-306, 2002.

S. Sumitran-holgersson, H. E. Wilczek, J. Holgersson, and K. Söderström, Identification of the nonclassical HLA molecules, mica, as targets for humoral immunity associated with irreversible rejection of kidney allografts, Transplantation, vol.74, pp.268-277, 2002.

R. W. Collins, H. A. Stephens, M. A. Clare, and R. W. Vaughan, High resolution molecular phototyping of MICA and MICB alleles using sequence specific primers, Hum. Immunol, vol.63, pp.783-794, 2002.

P. Tonnerre, N. Gérard, M. Chatelais, C. Poli, S. Allard et al., MICA variant promotes allosensitization after kidney transplantation, J. Am. Soc. Nephrol, vol.24, pp.954-966, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-02165869

T. W. Nilsen and B. R. Graveley, Expansion of the eukaryotic proteome by alternative splicing, Nature, vol.463, pp.457-463, 2010.

Z. Wang and C. B. Burge, Splicing regulation: from a parts list of regulatory elements to an integrated splicing code, RNA, vol.14, pp.802-813, 2008.

M. S. Krangel, Secretion of HLA-A and -B antigens via an alternative RNA splicing pathway, J. Exp. Med, vol.163, pp.1173-1190, 1986.

A. Ishitani and D. E. Geraghty, Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens, Proc. Natl. Acad. Sci, vol.89, pp.3947-3951, 1992.

B. Saposnik, E. Lesteven, A. Lokajczyk, C. T. Esmon, M. Aiach et al., Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma, Blood, vol.111, pp.3442-3451, 2008.

P. Riegert, V. Wanner, and S. Bahram, Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene, J. Immunol, vol.161, pp.4066-4077, 1998.

Y. Zou and P. Stastny, Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells, Immunogenetics, vol.54, pp.671-674, 2002.

S. Coupel, F. Leboeuf, G. Boulday, J. P. Soulillou, and B. Charreau, RhoA activation mediates phosphatidylinositol 3-kinase-dependent proliferation of human vascular endothelial cells: an alloimmune mechanism of chronic allograft nephropathy, J. Am. Soc. Nephrol, vol.15, pp.2429-2439, 2004.

P. Tonnerre, N. Gérard, M. Chatelais, and B. Charreau, MICA gene polymorphism in kidney allografts and possible impact of functionally relevant variants, Transplant. Proc, vol.42, pp.4318-4321, 2010.

Y. Katsuyama, M. Ota, H. Ando, S. Saito, N. Mizuki et al., Sequencing based typing for genetic polymorphisms in exons, 2, 3 and 4 of the MICA gene, Tissue Antigens, vol.54, pp.178-184, 1999.

C. S. Lengyel, L. J. Willis, P. Mann, D. Baker, T. Kortemme et al., Mutations designed to destabilize the receptor-bound conformation increase MICA-NKG2D association rate and affinity, J. Biol. Chem, vol.282, pp.30658-30666, 2007.

N. Obuchi, M. Takahashi, T. Nouchi, M. Satoh, T. Arimura et al., Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift-deletion in exon 4, Tissue Antigens, vol.57, pp.520-535, 2001.

X. Xu, W. Xia, L. Tian, Y. Chen, H. Ding et al., Distribution of MICA haplotypes in a Chinese Han population, Hum. Immunol, vol.73, pp.75-79, 2012.

A. Steinle, P. Li, D. L. Morris, V. Groh, L. L. Lanier et al., Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family, Immunogenetics, vol.53, pp.279-287, 2001.

P. Li, D. L. Morris, B. E. Willcox, A. Steinle, T. Spies et al., Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA, Nat. Immunol, vol.2, pp.443-451, 2001.

V. Groh, R. Rhinehart, J. Randolph-habecker, M. S. Topp, S. R. Riddell et al., Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells, Nat. Immunol, vol.2, pp.255-260, 2001.

L. I. Ehrlich, K. Ogasawara, J. A. Hamerman, R. Takaki, A. Zingoni et al., Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells, J. Immunol, vol.174, pp.1922-1931, 2005.

M. Kubin, L. Cassiano, J. Chalupny, W. Chin, D. Cosman et al., ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells, Eur. J. Immunol, vol.31, pp.1428-1437, 2001.

S. Gonzalez, J. Martinez-borra, J. C. Torre-alonso, S. Gonzalez-roces, J. Sanchez-del-río et al., The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis, Arthritis Rheum, vol.42, pp.1010-1016, 1999.

A. V. Romphruk, A. Romphruk, C. Choonhakarn, C. Puapairoj, H. Inoko et al., Major histocompatibility complex class I chain-related gene A in Thai psoriasis patients: MICA association as a part of human leukocyte antigen-B-Cw haplotypes, Tissue Antigens, vol.63, pp.547-554, 2004.

M. Champsaur and L. L. Lanier, Effect of NKG2D ligand expression on host immune responses, Immunol. Rev, vol.235, pp.267-285, 2010.

N. Stern-ginossar and O. Mandelboim, An integrated view of the regulation of NKG2D ligands, Immunology, vol.128, pp.1-6, 2009.

R. K. Strong, Asymmetric ligand recognition by the activating natural killer cell receptor NKG2D, a symmetric homodimer, Mol. Immunol, vol.38, pp.1029-1037, 2002.

V. Groh, J. Wu, C. Yee, and T. Spies, Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation, Nature, vol.419, pp.734-738, 2002.

H. R. Salih, H. G. Rammensee, and A. Steinle, Cutting edge: downregulation of MICA on human tumors by proteolytic shedding, J. Immunol, vol.169, pp.4098-4102, 2002.

H. R. Salih, S. Holdenrieder, and A. Steinle, Soluble NKG2D ligands: prevalence, release, and functional impact, Front. Biosci, vol.13, pp.3448-3456, 2008.

I. Waldhauer, D. Goehlsdorf, F. Gieseke, T. Weinschenk, M. Wittenbrink et al., Tumorassociated MICA is shed by ADAM proteases, Cancer Res, vol.68, pp.6368-6376, 2008.

D. Sun, X. Wang, H. Zhang, L. Deng, and Y. Zhang, MMP9 mediates MICA shedding in human osteosarcomas, Cell Biol. Int, vol.35, pp.569-574, 2011.

S. Holdenrieder, P. Stieber, A. Peterfi, D. Nagel, A. Steinle et al., Soluble MICA in malignant diseases, Int. J. Cancer, vol.118, pp.684-687, 2006.

W. Deng, B. G. Gowen, L. Zhang, L. Wang, S. Lau et al., Antitumor immunity: a shed NKG2D ligand that promotes natural killer cell activation and tumor rejection, Science, vol.348, pp.136-139, 2015.

S. Ag?-uera-gonzález, C. C. Gross, L. Fernández-messina, O. Ashiru, G. Esteso et al., Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding, Eur. J. Immunol, vol.41, pp.3667-3676, 2011.

X. Wang, A. D. Lundgren, P. Singh, D. R. Goodlett, S. R. Plymate et al., An six-amino acid motif in the alpha3 domain of MICA is the cancer therapeutic target to inhibit shedding, Biochem. Biophys. Res. Commun, vol.387, pp.476-481, 2009.

Z. Li, V. Groh, R. K. Strong, and T. Spies, A single amino acid substitution causes loss of expression of a MICA allele, Immunogenetics, vol.51, pp.246-248, 2000.

K. Ogasawara, J. A. Hamerman, L. R. Ehrlich, H. Bour-jordan, P. Santamaria et al., NKG2D blockade prevents autoimmune diabetes in NOD mice, Immunity, vol.20, pp.757-767, 2004.

H. N. Kloverpris, A. Stryhn, M. Harndahl, M. Van-der-stok, R. P. Payne et al., HLA-B*57 micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control, J. Virol, vol.86, pp.919-929, 2012.

M. B. Feinberg and R. Ahmed, Born this way? Understanding the immunological basis of effective HIV control, Nat. Immunol, vol.13, pp.632-634, 2012.

H. N. Kløverpris, M. Harndahl, A. J. Leslie, J. M. Carlson, N. Ismail et al., HIV control through a single nucleotide on the HLA-B locus, J. Virol, vol.86, pp.11493-11500, 2012.

L. Clerc, S. , O. Delaneau, C. Coulonges, J. L. Spadoni et al., Evidence after imputation for a role of MICA variants in nonprogression and elite control of HIV type 1 infection, J. Infect. Dis, vol.210, pp.1946-1950, 2014.