M. Haas, B. Sis, L. C. Racusen, K. Solez, D. Glotz et al., meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions, Am. J. Transplant, vol.14, pp.272-283, 2013.

F. Kissmeyer-nielsen, S. Olsen, V. P. Petersen, and O. Fjeldborg, Hyperacute rejection of kidney allografts, associated with pre-existing humoral antibodies against donor cells, Lancet, vol.2, pp.662-665, 1966.

P. F. Halloran, A. Wadgymar, S. Ritchie, J. Falk, K. Solez et al., The significance of the anti-class I antibody response. I. Clinical and pathologic features of anti-class I-mediated rejection, Transplantation, vol.49, pp.85-91, 1990.

P. F. Halloran, J. Schlaut, K. Solez, and N. S. Srinivasa, The significance of the anticlass I response. II. Clinical and pathologic features of renal transplants with anti-class I-like antibody, Transplantation, vol.53, pp.550-555, 1992.

H. E. Feucht, E. Felber, M. J. Gokel, G. Hillebrand, U. Nattermann et al., Vascular deposition of complement-split products in kidney allografts with cell-mediated rejection, Clin. Exp. Immunol, vol.86, pp.464-470, 1991.

H. Regele, G. A. Bohmig, A. Habicht, D. Gollowitzer, M. Schillinger et al., Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: a contribution of humoral immunity to chronic allograft rejection, J. Am. Soc. Nephrol, vol.13, pp.2371-2380, 2002.

G. Einecke, B. Sis, J. Reeve, M. Mengel, P. M. Campbell et al., Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure, Am. J. Transplant, vol.9, pp.2520-2531, 2009.

G. Opelz, Non-HLA transplantation immunity revealed by lymphocytotoxic antibodies, Lancet, vol.365, pp.1570-1576, 2005.

A. M. Jackson, M. B. Kuperman, and R. A. Montgomery, Multiple hyperacute rejections in the absence of detectable complement activation in a patient with endothelial cell reactive antibody, Am. J. Transplant, vol.12, pp.1643-1649, 2012.

S. C. Jordan, H. K. Yap, R. S. Sakai, P. Alfonso, and M. Fitchman, Hyperacute allograft rejection mediated by anti-vascular endothelial cell antibodies with a negative monocyte crossmatch, Transplantation, vol.46, pp.585-587, 1988.

A. W. Harmer, D. Haskard, C. G. Koffman, and K. I. Welsh, Novel antibodies associated with unexplained loss of renal allografts, Transpl. Int, vol.3, pp.66-69, 1990.

S. Sumitran-karuppan, G. Tyden, F. Reinholt, U. Berg, and E. Moller, Hyperacute rejections of two consecutive renal allografts and early loss of the third transplant caused by non-HLA antibodies specific for endothelial cells, Transpl. Immunol, vol.5, pp.321-327, 1997.

L. C. Paul, W. M. Baldwin-3rd, and L. A. Van-es, Vascular endothelial alloantigens in renal transplantation, Transplantation, vol.40, pp.117-123, 1985.

C. Lefaucheur, A. Loupy, G. S. Hill, J. Andrade, D. Nochy et al., Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation, J. Am. Soc. Nephrol, vol.21, pp.1398-1406, 2010.

P. Amico, G. Honger, D. Bielmann, D. Lutz, D. Garzoni et al., Incidence and prediction of early antibody-mediated rejection due to non-human leukocyte antigen-antibodies, Transplantation, vol.85, pp.1557-1563, 2008.

R. B. Colvin, Antibody-mediated renal allograft rejection: diagnosis and pathogenesis, J. Am. Soc. Nephrol, vol.18, pp.1046-1056, 2007.

L. Li, P. Wadia, R. Chen, N. Kambham, M. Naesens et al., Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and ''antibodyome" measures, Proc. Natl. Acad. Sci. U.S.A, vol.106, pp.4148-4153, 2009.

K. Spanel-borowski and G. Bein, Different microvascular endothelial cell phenotypes exhibit different class I and II antigens under interferon-gamma, In Vitro Cell. Dev. Biol. Anim, vol.29, pp.601-602, 1993.

E. Canet, J. Devalliere, N. Gerard, G. Karam, M. Giral et al., Profiling posttransplant circulating antibodies in kidney transplantation using donor endothelial cells, Transplantation, vol.93, pp.257-264, 2012.

D. Vermehren and S. Sumitran-holgersson, Isolation of precursor endothelial cells from peripheral blood for donor-specific crossmatching before organ transplantation, Transplantation, vol.74, pp.1479-1486, 2002.

M. E. Breimer, L. Rydberg, A. M. Jackson, D. P. Lucas, A. A. Zachary et al., Multicenter evaluation of a novel endothelial cell crossmatch test in kidney transplantation, Transplantation, vol.87, pp.549-556, 2009.

A. M. Jackson, D. P. Lucas, and J. L. Badders, A flow cytometric crossmatch test using endothelial precursor cells isolated from peripheral blood, Methods Mol. Biol, vol.1034, pp.319-329, 2013.

P. Xavier, P. Aires, S. Sampaio, C. Mendes, M. Monteiro et al., XM-ONE detection of endothelium cell antibodies identifies a subgroup of HLAantibody negative patients undergoing acute rejection, Transplant. Proc, vol.43, pp.91-94, 2011.

Q. Sun, Z. Cheng, D. Cheng, J. Chen, S. Ji et al., De novo development of circulating anti-endothelial cell antibodies rather than pre-existing antibodies is associated with post-transplant allograft rejection, Kidney Int, vol.79, pp.655-662, 2011.

J. Kalil, L. Guilherme, J. Neumann, C. Rosales, M. Marin et al., Humoral rejection in two HLA identical living related donor kidney transplants, Transplant. Proc, vol.21, pp.711-713, 1989.

S. Sumitran-holgersson, H. E. Wilczek, J. Holgersson, and K. Soderstrom, Identification of the nonclassical HLA molecules, mica, as targets for humoral immunity associated with irreversible rejection of kidney allografts, Transplantation, vol.74, pp.268-277, 2002.

K. G. Hankey, C. B. Drachenberg, J. C. Papadimitriou, D. K. Klassen, B. Philosophe et al., MIC expression in renal and pancreatic allografts, vol.73, pp.304-306, 2002.

I. Quiroga, M. Salio, D. D. Koo, L. Cerundolo, D. Shepherd et al., Expression of MHC class I-related Chain B (MICB) molecules on renal transplant biopsies, Transplantation, vol.81, pp.1196-1203, 2006.

K. Mizutani, P. Terasaki, E. Hamdani, V. Esquenazi, A. Rosen et al., The importance of anti-HLA-specific antibody strength in monitoring kidney transplant patients, Am. J. Transplant, vol.7, pp.1027-1031, 2007.

B. Suarez-alvarez, A. Lopez-vazquez, M. Z. Gonzalez, J. L. Fdez-morera, B. Diazmolina et al., The relationship of anti-MICA antibodies and MICA expression with heart allograft rejection, Am. J. Transplant, vol.7, pp.1842-1848, 2007.

A. Panigrahi, N. Gupta, J. A. Siddiqui, A. Margoob, D. Bhowmik et al., Monitoring of anti-HLA and anti-Major histocompatibility complex class I related chain A antibodies in living related renal donor transplantation, Transplant. Proc, vol.39, pp.759-760, 2007.

P. I. Terasaki, M. Ozawa, and R. Castro, Four-year follow-up of a prospective trial of HLA and MICA antibodies on kidney graft survival, Am. J. Transplant, vol.7, pp.408-415, 2007.

Y. Zou, P. Stastny, C. Susal, B. Dohler, and G. Opelz, Antibodies against MICA antigens and kidney-transplant rejection, N. Engl. J. Med, vol.357, pp.1293-1300, 2007.

Y. Zou and P. Stastny, Role of MICA in the immune response to transplants, Tissue Antigens, vol.76, pp.171-176, 2010.

K. Mizutani, P. I. Terasaki, R. N. Shih, R. Pei, M. Ozawa et al., Frequency of MIC antibody in rejected renal transplant patients without HLA antibody, Hum. Immunol, vol.67, pp.223-229, 2006.

P. Tonnerre, N. Gerard, M. Chatelais, C. Poli, S. Allard et al., MICA variant promotes allosensitization after kidney transplantation, J. Am. Soc. Nephrol, vol.24, pp.954-966, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-02165869

D. Dragun, D. N. Muller, J. H. Brasen, L. Fritsche, M. Nieminen-kelha et al., Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection, N. Engl. J. Med, vol.352, pp.558-569, 2005.

N. L. Reinsmoen, C. H. Lai, H. Heidecke, M. Haas, K. Cao et al., Antiangiotensin type 1 receptor antibodies associated with antibody mediated rejection in donor HLA antibody negative patients, Transplantation, vol.90, pp.1473-1477, 2010.

M. Giral, Y. Foucher, A. Dufay, J. P. Van-huyen, K. Renaudin et al., Pretransplant sensitization against angiotensin II type 1 receptor is a risk factor for acute rejection and graft loss, Am. J. Transplant, vol.13, pp.2567-2576, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-02165660

M. Taniguchi, L. M. Rebellato, J. Cai, J. Hopfield, K. P. Briley et al., Higher risk of kidney graft failure in the presence of anti-angiotensin II type-1 receptor antibodies, Am. J. Transplant, vol.13, pp.2577-2589, 2013.

N. E. Hiemann, R. Meyer, E. Wellnhofer, C. Schoenemann, H. Heidecke et al., Non-HLA antibodies targeting vascular receptors enhance alloimmune response and microvasculopathy after heart transplantation, Transplantation, vol.94, pp.919-924, 2012.

M. Banasik, M. Boratynska, K. Koscielska-kasprzak, M. Krajewska, O. Mazanowska et al., The impact of non-HLA antibodies directed against endothelin-1 type A receptors (ETAR) on early renal transplant outcomes, Transpl. Immunol, vol.30, pp.24-29, 2014.

F. Porcheray, J. Devito, B. Y. Yeap, L. Xue, I. Dargon et al., Chronic humoral rejection of human kidney allografts associates with broad autoantibody responses, Transplantation, vol.89, pp.1239-1246, 2010.

F. Porcheray, J. W. Fraser, B. Gao, A. Mccoll, J. Devito et al., Polyreactive antibodies developing amidst humoral rejection of human kidney grafts bind apoptotic cells and activate complement, Am. J. Transplant, vol.13, pp.2590-2600, 2013.

H. Ikematsu, M. T. Kasaian, E. W. Schettino, and P. Casali, Structural analysis of the VH-D-JH segments of human polyreactive IgG mAb. Evidence for somatic selection, J. Immunol, vol.151, pp.3604-3616, 1993.

B. Gao, C. Rong, F. Porcheray, C. Moore, T. C. Girouard et al., Evidence to support a contribution of polyreactive antibodies to HLA serum reactivity, Transplantation, vol.100, pp.217-226, 2016.

M. Soulez, E. A. Pilon, M. Dieude, H. Cardinal, N. Brassard et al., The perlecan fragment LG3 is a novel regulator of obliterative remodeling associated with allograft vascular rejection, Circ. Res, vol.110, pp.94-104, 2012.

E. O'riordan, T. N. Orlova, N. Mendelev, D. Patschan, R. Kemp et al., Urinary proteomic analysis of chronic allograft nephropathy, Proteomics Clin. Appl, vol.2, pp.1025-1035, 2008.

H. Cardinal, M. Dieude, N. Brassard, S. Qi, N. Patey et al., Antiperlecan antibodies are novel accelerators of immune-mediated vascular injury, Am. J. Transplant, vol.13, pp.861-874, 2013.
URL : https://hal.archives-ouvertes.fr/pasteur-01130364

S. Jurcevic, M. E. Ainsworth, A. Pomerance, J. D. Smith, D. R. Robinson et al., Antivimentin antibodies are an independent predictor of transplantassociated coronary artery disease after cardiac transplantation, Transplantation, vol.71, pp.886-892, 2001.

B. Mahesh, H. S. Leong, K. S. Nair, A. Mccormack, P. Sarathchandra et al., Autoimmunity to vimentin potentiates graft vasculopathy in murine cardiac allografts, Transplantation, vol.90, pp.4-13, 2010.

B. Mahesh, H. S. Leong, A. Mccormack, P. Sarathchandra, A. Holder et al., Autoantibodies to vimentin cause accelerated rejection of cardiac allografts, Am. J. Pathol, vol.170, pp.1415-1427, 2007.

R. S. Warraich, A. Pomerance, A. Stanley, N. R. Banner, M. J. Dunn et al., Cardiac myosin autoantibodies and acute rejection after heart transplantation in patients with dilated cardiomyopathy, Transplantation, vol.69, pp.1609-1617, 2000.

W. J. Burlingham, R. B. Love, E. Jankowska-gan, L. D. Haynes, Q. Xu et al., IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants, J. Clin. Invest, vol.117, pp.3498-3506, 2007.

T. A. Goers, S. Ramachandran, A. Aloush, E. Trulock, G. A. Patterson et al., De novo production of K-alpha1 tubulin-specific antibodies: role in chronic lung allograft rejection, J. Immunol, vol.180, pp.4487-4494, 2008.

N. Fukami, S. Ramachandran, D. Saini, M. Walter, W. Chapman et al., Antibodies to MHC class I induce autoimmunity: role in the pathogenesis of chronic rejection, J. Immunol, vol.182, pp.309-318, 2009.

D. Saini, J. Weber, S. Ramachandran, D. Phelan, V. Tiriveedhi et al., Alloimmunity-induced autoimmunity as a potential mechanism in the pathogenesis of chronic rejection of human lung allografts, J. Heart Lung Transplant, vol.30, pp.624-631, 2011.

N. Angaswamy, V. Tiriveedhi, N. J. Sarma, V. Subramanian, C. Klein et al., Interplay between immune responses to HLA and non-HLA self-antigens in allograft rejection, Hum. Immunol, vol.74, pp.1478-1485, 2013.

R. Dinavahi, A. George, A. Tretin, E. Akalin, S. Ames et al., Antibodies reactive to non-HLA antigens in transplant glomerulopathy, J. Am. Soc. Nephrol, vol.22, pp.1168-1178, 2011.

P. F. Halloran, Transplantation: Autoantibodies-epiphenomena or biological clues, Nat. Rev. Nephrol, vol.9, pp.705-706, 2013.

S. M. Sutherland, L. Li, T. K. Sigdel, P. P. Wadia, D. B. Miklos et al., Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients, Kidney Int, vol.76, pp.1277-1283, 2009.

S. L. Roux, A. Devys, C. Girard, J. Harb, and M. Hourmant, Biomarkers for the diagnosis of the stable kidney transplant and chronic transplant injury using the ProtoArray(R) technology, Transplant. Proc, vol.42, pp.3475-3481, 2010.

T. K. Sigdel, L. Li, T. Q. Tran, P. Khatri, M. Naesens et al., Non-HLA antibodies to immunogenic epitopes predict the evolution of chronic renal allograft injury, J. Am. Soc. Nephrol, vol.23, pp.750-763, 2012.

A. M. Jackson, T. K. Sigdel, M. Delville, S. C. Hsieh, H. Dai et al., Endothelial cell antibodies associated with novel targets and increased rejection, J. Am. Soc. Nephrol, vol.26, pp.1161-1171, 2015.

A. B. Collins, E. E. Schneeberger, M. A. Pascual, S. L. Saidman, W. W. Williams et al., Complement activation in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries, J. Am. Soc. Nephrol, vol.10, pp.2208-2214, 1999.

D. Dragun, R. Catar, and A. Philippe, Non-HLA antibodies in solid organ transplantation: recent concepts and clinical relevance, Curr. Opin. Organ Transplant, vol.18, pp.430-435, 2013.

J. C. Scornik, G. Guerra, J. D. Schold, T. R. Srinivas, D. Dragun et al., Value of posttransplant antibody tests in the evaluation of patients with renal graft dysfunction, Am. J. Transplant, vol.7, pp.1808-1814, 2007.

F. F. Yuan, N. Watson, J. S. Sullivan, S. Biffin, J. Moses et al., Association of Fc gamma receptor IIA polymorphisms with acute renalallograft rejection, Transplantation, vol.78, pp.766-769, 2004.

T. Resch, C. Fabritius, S. Ebner, P. Ritschl, and K. Kotsch, The role of natural killer cells in humoral rejection, Transplantation, vol.99, pp.1335-1340, 2015.

M. Crespo, J. Yelamos, D. Redondo, A. Muntasell, M. J. Perez-saez et al., Circulating NK-cell subsets in renal allograft recipients with anti-HLA donor-specific antibodies, Am. J. Transplant, vol.15, pp.806-814, 2015.

G. Vidarsson, G. Dekkers, and T. Rispens, IgG subclasses and allotypes: from structure to effector functions, Front. Immunol, vol.5, p.520, 2014.

S. , L. Bas-bernardet, S. Coupel, A. Chauveau, J. P. Soulillou et al., Vascular endothelial cells evade apoptosis triggered by human leukocyte antigen-DR ligation mediated by allospecific antibodies, Transplantation, vol.78, pp.1729-1739, 2004.

X. Zhang, E. Rozengurt, and E. F. Reed, HLA class I molecules partner with integrin beta4 to stimulate endothelial cell proliferation and migration, Sci. Signal, vol.3, p.85, 2010.

S. Coupel, F. Leboeuf, G. Boulday, J. P. Soulillou, and B. Charreau, RhoA activation mediates phosphatidylinositol 3-kinase-dependent proliferation of human vascular endothelial cells: an alloimmune mechanism of chronic allograft nephropathy, J. Am. Soc. Nephrol, vol.15, pp.2429-2439, 2004.

S. , L. Bas-bernardet, M. Hourmant, S. Coupel, J. D. Bignon et al., Non-HLA-type endothelial cell reactive alloantibodies in pretransplant sera of kidney recipients trigger apoptosis, Am. J. Transplant, vol.3, pp.167-177, 2003.

H. Regele, Non-HLA antibodies in kidney allograft rejection: convincing concept in need of further evidence, Kidney Int, vol.79, pp.583-586, 2011.