Error-Robust Modes of the Retinal Population Code

Jason Prentice 1 Olivier Marre 2 Mark Ioffe 1, 3 Adrianna Loback 1 Gašper Tkačik 4 Michael Berry 2nd 1, 5, *
* Corresponding author
1 PNI - Princeton Neuroscience Institute [Princeton, NJ, États-Unis]
2 Institut de la Vision
3 Department of Physics [Princeton, NJ, États-Unis]
4 IST Austria - Institute of Science and Technology [Austria]
5 Department of Molecular Biology [Princeton, NJ, États-Unis]
Abstract : Across the nervous system, certain population spiking patterns are observed far more frequently than others. A hypothesis about this structure is that these collective activity patterns function as population codewords-collective modes-carrying information distinct from that of any single cell. We investigate this phenomenon in recordings of ∼150 retinal ganglion cells, the retina's output. We develop a novel statistical model that decomposes the population response into modes; it predicts the distribution of spiking activity in the ganglion cell population with high accuracy. We found that the modes represent localized features of the visual stimulus that are distinct from the features represented by single neurons. Modes form clusters of activity states that are readily discriminated from one another. When we repeated the same visual stimulus, we found that the same mode was robustly elicited. These results suggest that retinal ganglion cells' collective signaling is endowed with a form of error-correcting code-a principle that may hold in brain areas beyond retina.
Document type :
Journal articles
Complete list of metadatas

Cited literature [102 references]  Display  Hide  Download
https://www.hal.inserm.fr/inserm-02149767
Contributor : Myriam Bodescot <>
Submitted on : Thursday, June 6, 2019 - 4:14:40 PM
Last modification on : Saturday, June 8, 2019 - 1:38:05 AM

File

journal.pcbi.1005148.pdf
Publication funded by an institution

Identifiers

Collections

U968 | SORBONNE-UNIVERSITE | SU-MEDECINE

Citation

Jason Prentice, Olivier Marre, Mark Ioffe, Adrianna Loback, Gašper Tkačik, et al.. Error-Robust Modes of the Retinal Population Code. PLoS Computational Biology, Public Library of Science, 2016, 12 (11), pp.e1005148. ⟨10.1371/journal.pcbi.1005148⟩. ⟨inserm-02149767⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

34

Files downloads

33

Contact

CCSD