E. Dugast, E. Kiss-toth, J. P. Soulillou, S. Brouard, and J. Ashton-chess, The Tribbles-1 protein in humans: roles and functions in health and disease, Curr. Mol. Med, vol.13, pp.80-85, 2013.

E. Kiss-toth, S. M. Bagstaff, H. Y. Sung, V. Jozsa, C. Dempsey et al., Human tribbles, a protein family controlling mitogen-activated protein kinase cascades, J. Biol. Chem, vol.279, pp.42703-42708, 2004.

J. Ashton-chess, M. Giral, M. Mengel, K. Renaudin, Y. Foucher et al., Tribbles-1 as a novel biomarker of chronic antibody-mediated rejection, J. Am. Soc. Nephrol, vol.19, pp.1116-1127, 2008.

H. Y. Sung, S. E. Francis, D. C. Crossman, and E. Kiss-toth, Regulation of expression and signalling modulator function of mammalian tribbles is cell-type specific, Immunol. Lett, vol.104, pp.171-177, 2006.

A. Ferraro, A. M. D'alise, T. Raj, N. Asinovski, R. Phillips et al., Interindividual variation in human T regulatory cells, Proc. Natl. Acad. Sci. U.S.A, vol.111, pp.1111-1120, 2014.

S. Pfoertner, A. Jeron, M. Probst-kepper, C. A. Guzman, W. Hansen et al., Signatures of human regulatory T cells: an encounter with old friends and new players, Genome Biol, vol.7, 2006.

E. Dugast, E. Kiss-toth, L. Docherty, R. Danger, M. Chesneau et al., Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells, J. Biol. Chem, vol.288, pp.10051-10060, 2013.

S. Sakaguchi, T. Yamaguchi, T. Nomura, and M. Ono, Regulatory T cells and immune tolerance, Cell, vol.133, pp.775-787, 2008.

H. Waldmann, R. Hilbrands, D. Howie, and S. Cobbold, Harnessing FOXP3 + regulatory T cells for transplantation tolerance, J. Clin. Invest, vol.124, pp.1439-1445, 2014.

O. Bestard, J. M. Cruzado, M. Mestre, A. Caldes, J. Bas et al., Achieving donor-specific hyporesponsiveness is associated with FOXP3 + regulatory T cell recruitment in human renal allograft infiltrates, J. Immunol, vol.179, pp.4901-4909, 2007.

O. Bestard, J. M. Cruzado, I. Rama, J. Torras, M. Goma et al., Presence of FoxP3 + regulatory T Cells predicts outcome of subclinical rejection of renal allografts, J. Am. Soc. Nephrol, vol.19, pp.2020-2026, 2008.

C. M. Alvarez, G. Opelz, L. F. Garcia, and C. Susal, Expression of regulatory T-cell-related molecule genes and clinical outcome in kidney transplant recipients, Transplantation, vol.87, pp.857-863, 2009.

C. Braudeau, M. Racape, M. Giral, S. Louis, A. Moreau et al., Variation in numbers of CD4 + CD25highFOXP3 + T cells with normal immuno-regulatory properties in long-term graft outcome, Transpl. Int, vol.20, pp.845-855, 2007.

S. Louis, C. Braudeau, M. Giral, A. Dupont, F. Moizant et al., Contrasting CD25hiCD4 + T cells/FOXP3 patterns in chronic rejection and operational drug-free tolerance, Transplantation, vol.81, pp.398-407, 2006.

F. Braza, E. Dugast, I. Panov, C. Paul, K. Vogt et al., Central role of CD45RA-Foxp3hi memory regulatory T cells in clinical kidney transplantation tolerance, J. Am. Soc. Nephrol, 2015.
URL : https://hal.archives-ouvertes.fr/inserm-02147767

J. D. Fontenot, M. A. Gavin, and A. Y. Rudensky, Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells, Nat. Immunol, vol.4, pp.330-336, 2003.

D. Rudra, P. Deroos, A. Chaudhry, R. E. Niec, A. Arvey et al., Transcription factor Foxp3 and its protein partners form a complex regulatory network, Nat. Immunol, vol.13, pp.1010-1019, 2012.

W. Fu, A. Ergun, T. Lu, J. A. Hill, S. Haxhinasto et al., A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells, Nat. Immunol, vol.13, pp.972-980, 2012.

G. Einecke, B. Sis, J. Reeve, M. Mengel, P. M. Campbell et al., Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure, Am. J. Transplant, vol.9, pp.2520-2531, 2009.

O. Thaunat, C. Legendre, E. Morelon, H. Kreis, and M. F. Mamzer-bruneel, To biopsy or not to biopsy? Should we screen the histology of stable renal grafts, Transplantation, vol.84, pp.671-676, 2007.

P. N. Furness, C. M. Philpott, M. T. Chorbadjian, M. L. Nicholson, J. L. Bosmans et al., Protocol biopsy of the stable renal transplant: a multicenter study of methods and complication rates, Transplantation, vol.76, pp.969-973, 2003.

H. Neuwirt, P. Perco, A. Kainz, I. Muhlberger, J. Leierer et al., A 3-biomarker-panel predicts renal outcome in patients with proteinuric renal diseases, BMC Med. Genomics, vol.7, 2014.

Y. H. Liu, K. A. Tan, I. W. Morrison, J. R. Lamb, and D. J. Argyle, Macrophage migration is controlled by Tribbles 1 through the interaction between C/EBPbeta and TNF-alpha, Vet. Immunol. Immunopathol, vol.155, pp.67-75, 2013.

T. Satoh, H. Kidoya, H. Naito, M. Yamamoto, N. Takemura et al., Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages, Nature, vol.495, pp.524-528, 2013.

M. Yamamoto, S. Uematsu, T. Okamoto, Y. Matsuura, S. Sato et al., Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency, J. Exp. Med, vol.204, pp.2233-2239, 2007.

I. Remy and S. W. Michnick, A cDNA library functional screening strategy based on fluorescent protein complementation assays to identify novel components of signaling pathways, Methods, vol.32, pp.381-388, 2004.

H. Y. Sung, H. Guan, A. Czibula, A. R. King, K. Eder et al., Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways, J. Biol. Chem, vol.282, pp.18379-18387, 2007.

Z. Hegedus, A. Czibula, and E. Kiss-toth, Tribbles: a family of kinase-like proteins with potent signalling regulatory function, Cell Signal, vol.19, pp.238-250, 2007.

D. C. Gilby, H. Y. Sung, P. R. Winship, A. C. Goodeve, J. T. Reilly et al., Tribbles-1 and -2 are tumour suppressors, down-regulated in human acute myeloid leukaemia, Immunol. Lett, vol.130, pp.115-124, 2010.

J. C. Vahl, C. Drees, K. Heger, S. Heink, J. C. Fischer et al., Continuous T cell receptor signals maintain a functional regulatory T cell pool, Immunity, vol.41, pp.722-736, 2014.

X. Zhou, L. T. Jeker, B. T. Fife, S. Zhu, M. S. Anderson et al., Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity, J. Exp. Med, vol.205, 1983.

H. L. Mai, F. Boeffard, J. Longis, R. Danger, B. Martinet et al., IL-7 receptor blockade following T cell depletion promotes long-term allograft survival, J. Clin. Invest, vol.124, pp.1723-1733, 2014.
DOI : 10.1172/jci66287
URL : http://europepmc.org/articles/pmc3973119?pdf=render