D. A. Hanley, M. R. Mcclung, K. S. Davison, L. Dian, S. T. Harris et al.,

D. L. , Western osteoporosis alliance clinical practice series: Evaluating the balance of benefits and risks of long-term osteoporosis therapies, Am. J. Med, vol.130, pp.862-863, 2017.

F. J. Lotters, I. Lenoir-wijnkoop, P. Fardellone, R. Rizzoli, E. Rocher et al., Dairy foods and osteoporosis: An example of assessing the health-economic impact of food products, Osteoporos. Int, pp.139-150, 2013.

M. L. Elam, M. L. Elam, S. A. Johnson, S. Hooshmand, R. G. Feresin et al., A calcium-collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia: A randomized controlled trial, J. Med. Food, vol.18, pp.324-331, 2015.

D. Konig, D. König, S. Oesser, S. Scharla, D. Zdzieblik et al., Specific collagen peptides improve bone mineral density and bone markers in Postmenopausal women-A randomized controlled study, Nutrients, vol.10, p.97, 2018.

J. Nieves, Skeletal effects of nutrients and nutraceuticals, beyond calcium and vitamin D, Osteoporos. Int, vol.24, pp.771-786, 2013.

S. Ricard-blum, The collagen family, Cold Spring Harb. Perspect. Biol, 2011.

S. Viguet-carrin, P. Garnero, and P. D. Delmas, The role of collagen in bone strength, Osteoporos Int, vol.17, pp.319-336, 2006.

J. D. Currey, Role of collagen and other organics in the mechanical properties of bone, Osteoporos Int, vol.14, pp.29-36, 2003.

R. W. Moskowitz, Role of collagen hydrolysate in bone and joint disease, Semin. Arthritis Rheum, vol.30, pp.87-99, 2000.

T. Trc and J. Bohmova, Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA), Int. Orthop, vol.35, pp.341-348, 2011.

T. Fujita, M. Ohue, Y. Fujii, A. Miyauchi, and Y. Takagi, The effect of active absorbable algal calcium (AAA Ca) with collagen and other matrix components on back and joint pain and skin impedance, J. Bone Miner. Metab, vol.20, pp.298-302, 2002.

O. Bruyere, B. Zegels, L. Leonori, V. Rabenda, A. Janssen et al., Effect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo controlled study, Complement. Ther. Med, vol.20, pp.124-130, 2012.

D. Bagchi, B. Misner, M. Bagchi, S. C. Kothari, B. W. Downs et al., Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration, Int. J. Clin. Pharmacol. Res, vol.22, pp.101-110, 2002.

Y. Henrotin, Y. Henrotin, C. Lambert, D. Couchourel, C. Ripoll et al., Nutraceuticals: do they represent a new era in the management of osteoarthritis?-A narrative review from the lessons taken with five products, Osteoarthr. Cartil, vol.19, pp.1-21, 2011.

S. Hooshmand, M. L. Elam, J. Browne, S. C. Campbell, and M. E. Payton, Evidence for bone reversal properties of a calcium-collagen chelate, a novel dietary supplement, J. Food Nutr. Disord, 2001.

F. Comblain, N. Barthélémy, M. Lefèbvre, C. Schwartz, I. Lesponne et al., A randomized, double-blind, prospective, placebo-controlled study of the efficacy of a diet supplemented with curcuminoids extract, hydrolyzed collagen and green tea extract in owner's dogs with osteoarthritis, BMC Vet. Res, p.395, 2017.

O. Bruyere, R. Rizzoli, V. Coxam, B. Avouac, T. Chevalier et al., Assessment of health claims in the field of bone: a view of the group for the respect of ethics and excellence in science (GREES), Osteoporos. Int, vol.23, pp.193-199, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00939644

Y. Wittrant, Y. Gorin, K. Woodruff, D. Horn, H. E. Abboud et al., High d (+) glucose concentration inhibits RANKL-induced osteoclastogenesis, vol.42, pp.1122-1130, 2008.

M. Adam, P. Spacek, H. Hulejova, A. Galianova, and J. Blahos, Postmenopausal osteoporosis. Treatment with calcitonin and a diet rich in collagen proteins, Cas. Lek. Cesk, vol.135, pp.74-78, 1996.

F. Cuneo, L. Costa-paiva, A. M. Pinto-neto, S. S. Morais, and J. Amaya-farfan, Effect of dietary supplementation with collagen hydrolysates on bone metabolism of postmenopausal women with low mineral density, Maturitas, vol.65, pp.253-257, 2010.

F. Guillerminet, H. Beaupied, V. Fabien-soulé, D. Tomé, C. L. Benhamou et al., Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo study, vol.46, pp.827-834, 2010.

F. Guillerminet, V. Fabien-soulé, P. C. Even, D. Tomé, C. L. Benhamou et al., Hydrolyzed collagen improves bone status and prevents bone loss in ovariectomized C3H/HeN mice, Osteoporos. Int, vol.23, pp.1909-1919, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00966726

T. Okiura, Y. Oishi, A. Takemura, and A. Ishihara, Effects of collagen hydrolysate on the tibialis anterior muscle and femur in senescence-accelerated mouse prone 6, J. Musculoskelet. Neuronal Interact, vol.16, pp.161-167, 2016.

L. Zhang, S. Zhang, H. Song, and B. Li, Effect of collagen hydrolysates from silver carp skin (hypophthalmichthys molitrix) on osteoporosis in chronologically aged mice: Increasing bone remodeling, Nutrients, vol.10, p.1434, 2018.

X. Liu, G. C. Machado, J. P. Eyles, V. Ravi, and D. J. Hunter, Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis, Br. J. Sports Med, vol.52, pp.167-175, 2018.

, Food and Drug Administration; Center for Drug Evaluation and Research. Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers, Pharmacol. Toxicol, 2005.

S. Ichikawa, M. Morifuji, H. Ohara, H. Matsumoto, Y. Takeuchi et al., Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate, Int. J. Food Sci. Nutr, vol.61, pp.52-60, 2010.

Y. Shigemura, D. Kubomura, Y. Sato, and K. Sato, Dose-dependent changes in the levels of free and peptide forms of hydroxyproline in human plasma after collagen hydrolysate ingestion, Food Chem, vol.159, pp.328-332, 2014.

Y. Taga, M. Kusubata, K. Ogawa-goto, and S. Hattori, Highly accurate quantification of hydroxyprolinecontaining peptides in blood using a protease digest of stable isotope-labeled collagen, J. Agric. Food Chem, vol.62, pp.12096-12102, 2014.

Y. Taga, M. Kusubata, K. Ogawa-goto, and S. Hattori, Identification of collagen-derived hydroxyproline (hyp)-containing cyclic dipeptides with high oral bioavailability: efficient formation of cyclo(x-hyp) from x-hyp-gly-type tripeptides by heating, J. Agric. Food Chem, vol.65, pp.9514-9521, 2017.

H. K. Kim, M. G. Kim, and K. H. Leem, Osteogenic activity of collagen peptide via ERK/MAPK pathway mediated boosting of collagen synthesis and its therapeutic efficacy in osteoporotic bone by back-scattered electron imaging and microarchitecture analysis, Molecules, vol.18, pp.15474-15489, 2013.

H. K. Kim, M. G. Kim, and K. H. Leem, Collagen hydrolysates increased osteogenic gene expressions via a MAPK signaling pathway in MG-63 human osteoblasts, Food Funct, vol.5, pp.573-578, 2014.
DOI : 10.1039/c3fo60509d

J. Liu, B. Zhang, S. Song, M. Ma, S. Si et al., Bovine collagen peptides compounds promote the proliferation and differentiation of MC3T3-E1 pre-osteoblasts, PLoS ONE, vol.9, p.99920, 2014.

S. Yamada, H. Nagaoka, M. Terajima, N. Tsuda, Y. Hayashi et al., Effects of fish collagen peptides on collagen post-translational modifications and mineralization in an osteoblastic cell culture system, Dent. Mater. J, vol.32, pp.88-95, 2013.

N. Tsuruoka, R. Yamato, Y. Sakai, Y. Yoshitake, and H. Yonekura, Promotion by collagen tripeptide of type I collagen gene expression in human osteoblastic cells and fracture healing of rat femur, Biosci. Biotechnol. Biochem, vol.71, pp.2680-2687, 2007.

S. Yamada, Y. Yoshizawa, A. Kawakubo, T. Ikeda, K. Yanagiguchi et al., Early gene and protein expression associated with osteoblast differentiation in response to fish collagen peptides powder, Dent. Mater. J, vol.32, pp.233-240, 2013.

C. Liu and J. Sun, Hydrolyzed tilapia fish collagen induces osteogenic differentiation of human periodontal ligament cells, Biomed. Mater, vol.10, p.65020, 2015.

T. Kawaguchi, P. N. Nanbu, and M. Kurokawa, Distribution of prolylhydroxyproline and its metabolites after oral administration in rats, Biol. Pharm. Bull, vol.35, pp.422-427, 2012.

P. Dimitri and C. Rosen, Fat and bone: Where are we now? Calcif. Tissue Int, vol.100, pp.431-432, 2017.

C. Tagliaferri, J. Salles, J. F. Landrier, C. Giraudet, V. Patrac et al., Increased body fat mass and tissue lipotoxicity associated with ovariectomy or high-fat diet differentially affects bone and skeletal muscle metabolism in rats, Eur. J. Nutr, vol.54, pp.1139-1149, 2015.

K. H. Ding, M. Cain, M. Davis, C. Bergson, M. Mcgee-lawrence et al., Amino acids as signaling molecules modulating bone turnover, vol.115, pp.15-24, 2018.

Y. Mine, Y. Mine, S. Makihira, Y. Yamaguchi, H. Tanaka et al., Involvement of ERK and p38 MAPK pathways on Interleukin-33-induced RANKL expression in osteoblastic cells, Cell Biol. Int, vol.38, pp.655-662, 2014.

M. Mizuno and Y. Kuboki, Osteoblast-related gene expression of bone marrow cells during the osteoblastic differentiation induced by type I collagen, J. Biochem, vol.129, pp.133-138, 2001.

A. Daneault, J. Prawitt, V. Fabien-soulé, V. Coxam, and Y. Wittrant, Biological effect of hydrolyzed collagen on bone metabolism, Crit. Rev. Food Sci. Nutr, vol.57, pp.1922-1937, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01506655

S. Kumar, F. Sugihara, K. Suzuki, N. Inoue, and S. Venkateswarathirukumara, A double-blind, placebocontrolled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis, J. Sci. Food Agric, vol.95, pp.702-707, 2015.

M. Watanabe-kamiyama, M. Shimizu, S. Kamiyama, Y. Taguchi, H. Sone et al., Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats, J. Agric. Food Chem, vol.58, pp.835-841, 2010.

K. H. Leem, S. Lee, A. Jang, and H. K. Kim, Porcine skin gelatin hydrolysate promotes longitudinal bone growth in adolescent rats, J. Med. Food, vol.16, pp.447-453, 2013.

M. C. Walsh and Y. Choi, Biology of the RANKL-RANK-OPG system in immunity, bone, and beyond, Front. Immunol, vol.5, p.511, 2014.