Modulation of Host Immunity by the Human Metapneumovirus - Archive ouverte HAL Access content directly
Journal Articles Clinical Microbiology Reviews Year : 2016

Modulation of Host Immunity by the Human Metapneumovirus

(1) , (1) , (2, 1, 3) , (1)
1
2
3

Abstract

Globally,asaleadingagentofacuterespiratorytractinfectionsin children 5 years of age and the elderly, the human metapneumovirus (HMPV) has gained considerable attention. As inferred from studies comparing vaccinated and experimentally infected mice,theacquiredimmuneresponseelicitedbythispathogenfails to efficiently clear the virus from the airways, which leads to an exaggerated inflammatory response and lung damage. Furthermore, after disease resolution, there is a poor development of T and B cell immunological memory, which is believed to promote reinfectionsandviralspreadinthecommunity.Inthisarticle,we discuss the molecular mechanisms that shape the interactions of HMPVwithhosttissuesthatleadtopulmonarypathologyandto thedevelopmentofadaptiveimmunitythatfailstoprotectagainst natural infections by this virus.
Embargoed file
Embargoed file
Ne sera jamais visible
Loading...

Dates and versions

inserm-02149051 , version 1 (06-06-2019)

Identifiers

Cite

Pablo F Céspedes, Christian E Palavecino, Alexis M Kalergis, Susan M Bueno. Modulation of Host Immunity by the Human Metapneumovirus. Clinical Microbiology Reviews, 2016, 29 (4), pp.795-818. ⟨10.1128/CMR.00081-15⟩. ⟨inserm-02149051⟩
20 View
1 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More