Abstract : Globally,asaleadingagentofacuterespiratorytractinfectionsin children 5 years of age and the elderly, the human metapneumovirus (HMPV) has gained considerable attention. As inferred from studies comparing vaccinated and experimentally infected mice,theacquiredimmuneresponseelicitedbythispathogenfails to efficiently clear the virus from the airways, which leads to an exaggerated inflammatory response and lung damage. Furthermore, after disease resolution, there is a poor development of T and B cell immunological memory, which is believed to promote reinfectionsandviralspreadinthecommunity.Inthisarticle,we discuss the molecular mechanisms that shape the interactions of HMPVwithhosttissuesthatleadtopulmonarypathologyandto thedevelopmentofadaptiveimmunitythatfailstoprotectagainst natural infections by this virus.
https://www.hal.inserm.fr/inserm-02149051
Contributor : Ana Paula Dutra Azevedo
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Pablo Céspedes, Christian Palavecino, Alexis Kalergis, Susan Bueno. Modulation of Host Immunity by the Human Metapneumovirus. Clinical Microbiology Reviews, American Society for Microbiology, 2016, 29 (4), pp.795-818. ⟨10.1128/CMR.00081-15⟩. ⟨inserm-02149051⟩
