Skip to Main content Skip to Navigation
Journal articles

Modulation of Host Immunity by the Human Metapneumovirus

Abstract : Globally,asaleadingagentofacuterespiratorytractinfectionsin children 5 years of age and the elderly, the human metapneumovirus (HMPV) has gained considerable attention. As inferred from studies comparing vaccinated and experimentally infected mice,theacquiredimmuneresponseelicitedbythispathogenfails to efficiently clear the virus from the airways, which leads to an exaggerated inflammatory response and lung damage. Furthermore, after disease resolution, there is a poor development of T and B cell immunological memory, which is believed to promote reinfectionsandviralspreadinthecommunity.Inthisarticle,we discuss the molecular mechanisms that shape the interactions of HMPVwithhosttissuesthatleadtopulmonarypathologyandto thedevelopmentofadaptiveimmunitythatfailstoprotectagainst natural infections by this virus.
Document type :
Journal articles
Complete list of metadata

Cited literature [271 references]  Display  Hide  Download
Contributor : Sylvie Le Bihan Connect in order to contact the contributor
Submitted on : Thursday, June 6, 2019 - 9:55:59 AM
Last modification on : Wednesday, April 27, 2022 - 4:17:17 AM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Pablo F Céspedes, Christian E Palavecino, Alexis M Kalergis, Susan M Bueno. Modulation of Host Immunity by the Human Metapneumovirus. Clinical Microbiology Reviews, American Society for Microbiology, 2016, 29 (4), pp.795-818. ⟨10.1128/CMR.00081-15⟩. ⟨inserm-02149051⟩



Record views