 |
Journal articles
Modulation of Host Immunity by the Human Metapneumovirus
Abstract : Globally,asaleadingagentofacuterespiratorytractinfectionsin children 5 years of age and the elderly, the human metapneumovirus (HMPV) has gained considerable attention. As inferred from studies comparing vaccinated and experimentally infected mice,theacquiredimmuneresponseelicitedbythispathogenfails to efficiently clear the virus from the airways, which leads to an exaggerated inflammatory response and lung damage. Furthermore, after disease resolution, there is a poor development of T and B cell immunological memory, which is believed to promote reinfectionsandviralspreadinthecommunity.Inthisarticle,we discuss the molecular mechanisms that shape the interactions of HMPVwithhosttissuesthatleadtopulmonarypathologyandto thedevelopmentofadaptiveimmunitythatfailstoprotectagainst natural infections by this virus.
Cited literature [271 references]
https://www.hal.inserm.fr/inserm-02149051
Contributor : Sylvie Le Bihan <>
Submitted on : Thursday, June 6, 2019 - 9:55:59 AM
Last modification on : Tuesday, August 13, 2019 - 2:30:12 PM
Contributor : Sylvie Le Bihan <>
Submitted on : Thursday, June 6, 2019 - 9:55:59 AM
Last modification on : Tuesday, August 13, 2019 - 2:30:12 PM