J. S. Smolen, Combating the burden of musculoskeletal conditions, Ann. Rheum. Dis, vol.63, pp.329-329, 2004.

J. S. Smolen, D. Aletaha, and I. B. Mcinnes, Lancet Lond. Engl

A. Najm, Biochemical Pharmacology, issue.16, pp.30173-30181, 2016.

M. Bonafede, K. M. Fox, C. Watson, N. Princic, and S. R. Gandra, Treatment patterns in the first year after initiating tumor necrosis factor blockers in real-world settings, Adv. Ther, vol.29, pp.664-674, 2012.

R. C. Lee and V. Ambros, An extensive class of small RNAs in Caenorhabditis elegans, Science, pp.262945543862-4, 2001.

L. He, J. M. Thomson, M. T. Hemann, E. Hernando-monge, D. Mu et al., A microRNA polycistron as a potential human oncogene, Nature, vol.435, pp.828-833, 2005.

B. Ory, M. R. Ramsey, C. Wilson, D. D. Vadysirisack, N. Forster et al., A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma, J. Clin. Invest, 2011.

C. Jacques, L. R. Calleja, M. Baud'huin, T. Quillard, D. Heymann et al., Ory, miRNA-193a-5p repression of p73 controls Cisplatin chemoresistance in primary bone tumors, Oncotarget, pp.2373454503-54514, 2016.

R. Rupaimoole and F. J. Slack, MicroRNA therapeutics: towards a new era for the management of cancer and other diseases, Nat. Rev. Drug Discov, vol.16, pp.203-222, 2017.

R. E. Lanford, E. S. Hildebrandt-eriksen, A. Petri, R. Persson, M. Lindow et al., Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection, Science, vol.327, pp.198-201, 2010.

C. L. Daige, J. F. Wiggins, L. Priddy, T. Nelligan-davis, J. Zhao et al., Systemic delivery of a miR34a mimic as a potential therapeutic for liver cancer, Mol. Cancer Ther, vol.13, pp.2352-2360, 2014.

R. Kalla, N. T. Ventham, N. A. Kennedy, J. F. Quintana, E. R. Nimmo et al., MicroRNAs: new players in IBD, vol.64, pp.504-517, 2015.

Q. Yang, W. Pan, and L. Qian, Identification of the miRNA-mRNA regulatory network in multiple sclerosis, Neurol. Res, vol.39, pp.142-151, 2017.

C. Staedel and F. Darfeuille, MicroRNAs and bacterial infection, Cell. Microbiol, vol.15, pp.1496-1507, 2013.

B. Kolarz and M. Majdan, Epigenetic aspects of rheumatoid arthritis: contribution of non-coding RNAs, Semin. Arthritis Rheum, vol.46, pp.724-731, 2017.

A. Pelosi, C. Lunardi, P. F. Fiore, E. Tinazzi, G. Patuzzo et al., MicroRNA expression profiling in psoriatic arthritis, BioMed Res. Int, vol.7305380, 2018.

Z. Li, S. H. Wong, J. Shen, M. T. Chan, and W. K. Wu, The role of microRNAS in ankylosing spondylitis, Medicine (Baltimore), vol.95, 2016.

C. Zhang, C. Wang, Z. Jia, W. Tong, D. Liu et al., Differentially expressed mRNAs, lncRNAs, and miRNAs with associated co-expression and ceRNA networks in ankylosing spondylitis, Oncotarget, vol.8, pp.113543-113557, 2017.

C. S. Fuziwara and E. T. Kimura, Insights into regulation of the miR-17-92 cluster of miRNAs in cancer, Front. Med, vol.2, 2015.

L. Philippe, G. Alsaleh, G. Suffert, A. Meyer, P. Georgel et al., TLR2 expression is regulated by microRNA miR-19 in rheumatoid fibroblast-like synoviocytes, J. Immunol. Baltim. Md, vol.1950, issue.188, pp.454-461, 2012.

L. Philippe, G. Alsaleh, A. Pichot, E. Ostermann, G. Zuber et al., MiR-20a regulates ASK1 expression and TLR4-dependent cytokine release in rheumatoid fibroblast-like synoviocytes, Ann. Rheum. Dis, vol.72, pp.1071-1079, 2013.

L. Philippe, G. Alsaleh, S. Bahram, S. Pfeffer, and P. Georgel, The miR-17 ? 92 cluster: a key player in the control of inflammation during rheumatoid arthritis, Front. Immunol, vol.4, 2013.

N. Akhtar, A. K. Singh, and S. Ahmed, MicroRNA-17 suppresses TNF-? signaling by interfering with TRAF2 and cIAP2 association in rheumatoid arthritis synovial fibroblasts, J. Immunol, vol.197, pp.2219-2228, 2016.

X. Li, W. Shen, Y. Sun, W. Li, Z. Sun et al., MicroRNA-20a negatively regulates expression of NLRP3-inflammasome by targeting TXNIP in adjuvant-induced arthritis fibroblast-like synoviocytes, J. Bone Spine Rev. Rheum, vol.83, pp.695-700, 2016.

M. Trenkmann, M. Brock, R. E. Gay, B. A. Michel, S. Gay et al., Tumor necrosis factor ?-induced microRNA-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-?B signaling: miR-18a enhances NF-?B signaling in RASFs, Arthritis Rheum, vol.65, pp.916-927, 2013.

Z. Wang, H. Lu, Q. Zhou, S. Yu, Y. Mao et al., MiR-451 inhibits synovial fibroblasts proliferation and inflammatory cytokines secretion in rheumatoid arthritis through mediating p38MAPK signaling pathway, Int. J. Clin. Exp. Pathol, vol.8, pp.14562-14567, 2015.

B. Zhang, L. Wang, and Y. Zhou, Elevated microRNA-125b promotes inflammation in rheumatoid arthritis by activation of NF-?B pathway, Biomed. Pharmacother. Biomed. Pharmacother, vol.93, pp.1151-1157, 2017.

V. Saferding, A. Puchner, E. Goncalves-alves, M. Hofmann, M. Bonelli et al., MicroRNA146a governs fibroblast activation and joint pathology in arthritis, J. Autoimmun, vol.82, pp.74-84, 2017.

Y. Jiang and L. Wang, Role of histone deacetylase 3 in ankylosing spondylitis via negative feedback loop with microRNA-130a and enhancement of tumor necrosis factor-1? expression in peripheral blood mononuclear cells, Mol. Med. Rep, vol.13, pp.35-40, 2016.

S. Lefèvre, A. Knedla, C. Tennie, A. Kampmann, C. Wunrau et al., Synovial fibroblasts spread rheumatoid arthritis to unaffected joints, Nat. Med, vol.15, pp.1414-1420, 2009.

A. Baier, I. Meineckel, S. Gay, and T. Pap, Apoptosis in rheumatoid arthritis, Curr. Opin. Rheumatol, vol.15, pp.274-279, 2003.

Y. Qu, J. Wu, J. Deng, Y. Zhang, W. Liang et al., MicroRNA-126 affects rheumatoid arthritis synovial fibroblast proliferation and apoptosis by targeting PIK3R2 and regulating PI3K-AKT signal pathway, Oncotarget, vol.7, 2016.

J. Gao, X. Zhou, R. Kong, L. Ji, L. He et al., MicroRNA-126 targeting PIK3R2 promotes rheumatoid arthritis synovial fibro-blasts proliferation and resistance to apoptosis by regulating PI3K/AKT pathway, Exp. Mol. Pathol, vol.100, pp.192-198, 2016.

S. Yang and Y. Yang, Downregulation of microRNA-221 decreases migration and invasion in fibroblast-like synoviocytes in rheumatoid arthritis, Mol. Med. Rep, vol.12, pp.2395-2401, 2015.

S. Kawano and Y. Nakamachi, miR-124a as a key regulator of proliferation and MCP-1 secretion in synoviocytes from patients with rheumatoid arthritis, Ann. Rheum. Dis, vol.70, pp.88-91, 2011.

Y. Sun, X. Sun, Z. Liu, X. Wang, and Y. Li, MiR-338-5p suppresses rheumatoid arthritis synovial fibroblast proliferation and invasion by targeting ADAMTS-9, Clin. Exp. Rheumatol, vol.36, pp.195-202, 2018.

T. Guo, H. Ding, H. Jiang, N. Bao, L. Zhou et al., miR-338-5p regulates the viability, proliferation, apoptosis and migration of rheumatoid arthritis fibroblastlike synoviocytes by targeting NFAT5, Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol, vol.49, pp.899-910, 2018.

J. Guo, J. Du, D. Fei, J. Xing, J. Liu et al., miR-152 inhibits rheumatoid arthritis synovial fibroblast proliferation and induces apoptosis by targeting ADAM10, Int. J. Mol. Med, vol.42, pp.643-650, 2018.

J. Liu, D. Fei, J. Xing, and J. Du, MicroRNA-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing STAT3, Biomed. Pharmacother. Biomed. Pharmacother, vol.96, pp.173-181, 2017.

H. Li, S. Guan, Y. Lu, and F. Wang, MiR-140-5p inhibits synovial fibroblasts proliferation and inflammatory cytokines secretion through targeting TLR4, Biomed. Pharmacother. Biomed. Pharmacother, vol.96, pp.208-214, 2017.

J. Du, F. Zhang, and J. Guo, miR-137 decreases proliferation, migration and invasion in rheumatoid arthritis fibroblast-like synoviocytes, Mol. Med. Rep, vol.17, pp.3312-3317, 2018.

X. Xu, H. Chen, Q. Zhang, J. Xu, Q. Shi et al., MiR-650 inhibits proliferation, migration and invasion of rheumatoid arthritis synovial fibroblasts by targeting AKT2, Biomed. Pharmacother. Biomed. Pharmacother, vol.88, pp.535-541, 2017.

J. Sun, P. Yan, Y. Chen, Y. Chen, J. Yang et al., MicroRNA-26b inhibits cell proliferation and cytokine secretion in human RASF cells via the Wnt/ GSK-3?/?-catenin pathway, Diagn. Pathol, vol.10, 2015.

G. Alsaleh, A. François, L. Philippe, Y. Gong, S. Bahram et al., MiR-30a-3p negatively regulates BAFF synthesis in systemic sclerosis and rheumatoid arthritis fibroblasts, PLoS One, vol.9, p.111266, 2014.

A. Ruedel, P. Dietrich, T. Schubert, S. Hofmeister, C. Hellerbrand et al., Expression and function of microRNA-188-5p in activated rheumatoid arthritis synovial fibroblasts, Int. J. Clin. Exp. Pathol, vol.8, pp.4953-4962, 2015.

F. Niederer, M. Trenkmann, C. Ospelt, E. Karouzakis, M. Neidhart et al., Down-regulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance, Arthritis Rheum, vol.64, pp.1771-1779, 2012.

S. Li, Z. Jin, and X. Lu, MicroRNA-192 suppresses cell proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes by downregulating caveolin 1, Mol. Cell. Biochem, vol.432, pp.123-130, 2017.

Y. Takamura, W. Aoki, A. Satomura, S. Shibasaki, and M. Ueda, Small RNAs detected in exosomes derived from the MH7A synovial fibroblast cell line with TNF-? stimulation, PLoS One, vol.13, p.201851, 2018.

G. S. Schulert, N. Fall, J. B. Harley, N. Shen, D. J. Lovell et al., Monocyte microRNA expression in active systemic juvenile idiopathic arthritis implicates microRNA-125a-5p in polarized monocyte phenotypes, Arthritis Rheumatol, vol.68, pp.2300-2313, 2016.

D. Li, M. Duan, Y. Feng, L. Geng, X. Li et al., MiR-146a modulates macrophage polarization in systemic juvenile idiopathic arthritis by targeting INHBA, Biochemical Pharmacology

, Mol. Immunol, vol.77, pp.205-212, 2016.

M. Rajasekhar, A. M. Olsson, K. J. Steel, M. Georgouli, U. Ranasinghe et al., MicroRNA-155 contributes to enhanced resistance to apoptosis in monocytes from patients with rheumatoid arthritis, J. Autoimmun, vol.79, pp.53-62, 2017.

D. R. Littman and A. Y. Rudensky, Th17 and regulatory T cells in mediating and restraining inflammation, Cell, vol.140, pp.845-858, 2010.

W. Wang, S. Shao, Z. Jiao, M. Guo, H. Xu et al., The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis, Rheumatol. Int, vol.32, pp.887-893, 2012.

M. Noack and P. Miossec, Th17 and regulatory T cell balance in autoimmune and inflammatory diseases, Autoimmun. Rev, vol.13, pp.668-677, 2014.

K. Smigielska-czepiel, A. Van-den, P. Berg, R. J. Jellema, J. Van-der-lei et al., Comprehensive analysis of miRNA expression in T-cell subsets of rheumatoid arthritis patients reveals defined signatures of naive and memory Tregs, Genes Immun, vol.15, pp.115-125, 2014.

E. Stagakis, G. Bertsias, P. Verginis, M. Nakou, M. Hatziapostolou et al., Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression, Ann. Rheum. Dis, vol.70, pp.1496-1506, 2011.

K. S. Van-der-geest, K. Smigielska-czepiel, J. Park, W. H. Abdulahad, H. Kim et al., SF Treg cells transcribing high levels of Bcl-2 and microRNA-21 demonstrate limited apoptosis in RA, Rheumatol. Oxf. Engl, vol.54, pp.950-958, 2015.

L. Dong, X. Wang, J. Tan, H. Li, W. Qian et al., Decreased expression of microRNA-21 correlates with the imbalance of Th17 and Treg cells in patients with rheumatoid arthritis, J. Cell. Mol. Med, vol.18, pp.2213-2224, 2014.

S. Jin, H. Chen, Y. Li, H. Zhong, W. Sun et al., Maresin 1 improves the Treg/Th17 imbalance in rheumatoid arthritis through miR-21, Ann. Rheum. Dis, vol.77, pp.1644-1652, 2018.

S. Alivernini, E. Gremese, C. Mcsharry, B. Tolusso, G. Ferraccioli et al., MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis, Front. Immunol, vol.8, 1932.

S. Blüml, M. Bonelli, B. Niederreiter, A. Puchner, G. Mayr et al., Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice, Arthritis Rheum, vol.63, pp.1281-1288, 2011.

T. Nakasa, H. Shibuya, Y. Nagata, T. Niimoto, and M. Ochi, The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis, Arthritis Rheum, vol.63, pp.1582-1590, 2011.

, Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis, Ann. Rheum. Dis, 2018.

Y. Wu, W. Liu, B. Xue, L. Zhang, X. Liu et al., Upregulated expression of microRNA-16 correlates with Th17/Treg cell imbalance in patients with rheumatoid arthritis, DNA Cell Biol, vol.35, pp.853-860, 2016.

L. Wang, C. Wang, X. Jia, and J. Yu, Circulating exosomal miR-17 inhibits the induction of regulatory T cells via suppressing TGFBR II expression in rheumatoid arthritis, Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol, vol.50, pp.1754-1763, 2018.

X. Tang, K. Yin, H. Zhu, J. Tian, D. Shen et al., Correlation between the expression of microRNA-301a-3p and the proportion of Th17 cells in patients with rheumatoid arthritis, Inflammation, vol.39, pp.759-767, 2016.

Y. Li, S. Chen, C. Wang, M. Liu, C. Lin et al., Brief report: amelioration of collagen-induced arthritis in mice by lentivirus-mediated silencing of microRNA-223, Arthritis Rheum, vol.64, pp.3240-3245, 2012.

G. D. Sebastiani, V. Fulci, S. Niccolini, C. Giannitti, S. Bugatti et al., Over-expression of miR-223 in T-lymphocytes of early rheumatoid arthritis patients, Clin. Exp. Rheumatol, vol.29, pp.1058-1059, 2011.

V. Fulci, G. Scappucci, G. D. Sebastiani, C. Giannitti, D. Franceschini et al., miR-223 is overexpressed in T-lymphocytes of patients affected by rheumatoid arthritis, Hum. Immunol, vol.71, pp.206-211, 2010.

A. Stittrich, C. Haftmann, E. Sgouroudis, A. A. Kühl, A. N. Hegazy et al., The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes, Nat. Immunol, vol.11, pp.1057-1062, 2010.

J. A. Smith and R. A. Colbert, Review: the interleukin-23/interleukin-17 axis in spondyloarthritis pathogenesis: Th17 and beyond, Arthritis Rheumatol. Hoboken NJ, vol.66, pp.231-241, 2014.

L. Chen, M. H. Al-mossawi, A. Ridley, T. Sekine, A. Hammitzsch et al., Bowness, miR-10b-5p is a novel Th17 regulator present in Th17 cells from ankylosing spondylitis, Ann. Rheum. Dis, vol.76, pp.620-625, 2017.

N. Lai, H. Yu, H. Chen, C. Yu, H. Huang et al., Aberrant expression of microRNAs in T cells from patients with ankylosing spondylitis contributes to the immunopathogenesis, Clin. Exp. Immunol, vol.173, pp.47-57, 2013.

S. Alivernini, M. Kurowska-stolarska, B. Tolusso, R. Benvenuto, A. Elmesmari et al., MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis, Nat. Commun, vol.7, 2016.

A. Van-nieuwenhuijze, J. Dooley, S. Humblet-baron, J. Sreenivasan, M. Koenders et al., Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice, Cell. Mol. Life Sci. CMLS, vol.74, pp.2095-2106, 2017.

K. Murata, M. Furu, H. Yoshitomi, M. Ishikawa, H. Shibuya et al., Comprehensive microRNA analysis identifies miR-24 and miR-125a-5p as plasma biomarkers for rheumatoid arthritis, PLoS One, vol.8, 2013.

I. Duroux-richard, Y. Pers, S. Fabre, M. Ammari, D. Baeten et al., Circulating miRNA-125b is a potential biomarker predicting response to rituximab in rheumatoid arthritis, Mediators Inflamm, vol.342524, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01845068

I. Pandis, C. Ospelt, N. Karagianni, M. C. Denis, M. Reczko et al., Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model, Ann. Rheum. Dis, vol.71, pp.1716-1723, 2012.

T. Xu, C. Huang, Z. Chen, and J. Li, MicroRNA-323-3p: a new biomarker and potential therapeutic target for rheumatoid arthritis, Rheumatol. Int, vol.34, pp.721-722, 2014.

V. Anaparti, I. Smolik, X. Meng, V. Spicer, N. Mookherjee et al., Whole blood microRNA expression pattern differentiates patients with rheumatoid arthritis, their seropositive first-degree relatives, and healthy unrelated control subjects, Arthritis Res. Ther, vol.19, 2017.

M. Filková, B. Aradi, L. ?enolt, C. Ospelt, S. Vettori et al., Association of circulating miR-223 and miR-16 with disease activity in patients with early rheumatoid arthritis, Ann. Rheum. Dis, vol.73, pp.1898-1904, 2014.

C. Castro-villegas, C. Pérez-sánchez, A. Escudero, I. Filipescu, M. Verdu et al., Circulating miRNAs as potential biomarkers of therapy effectiveness in rheumatoid arthritis patients treated with anti-TNF?, Arthritis Res. Ther, vol.17, p.49, 2015.

J. C. Fernández-ruiz, C. Ramos-remus, J. Sánchez-corona, J. D. Castillo-ortiz, J. J. Castañeda-sánchez et al., Analysis of miRNA expression in patients with rheumatoid arthritis during remission and relapse after a 5-year trial of tofacitinib treatment, Int. Immunopharmacol, vol.63, pp.35-42, 2018.

S. B. Krintel, C. Dehlendorff, M. L. Hetland, K. Hørslev-petersen, K. K. Andersen et al., Prediction of treatment response to adalimumab: a double-blind placebo-controlled study of circulating microRNA in patients with early rheumatoid arthritis, Pharmacogenomics J, vol.16, pp.141-146, 2016.

H. Hong, H. Yang, and Y. Xia, Circulating miR-10a as predictor of therapy response in rheumatoid arthritis patients treated with methotrexate, Curr. Pharm. Biotechnol, 2017.

J. Huang, G. Song, Z. Yin, X. Luo, and Z. Ye, Elevated miR-29a expression is not correlated with disease activity index in PBMCs of patients with ankylosing spondylitis, Mod. Rheumatol, vol.24, pp.331-334, 2014.

Q. Lv, Q. Li, P. Zhang, Y. Jiang, X. Wang et al., Disorders of microRNAs in peripheral blood mononuclear cells: as novel biomarkers of ankylosing spondylitis and provocative therapeutic targets, BioMed Res. Int, vol.504208, 2015.

K. Prajzlerová, K. Grobelná, M. Hu?áková, ?. Forejtová, A. Jüngel et al., Association between circulating miRNAs and spinal involvement in patients with axial spondyloarthritis, PLoS One, vol.12, p.185323, 2017.

A. Najm, Biochemical Pharmacology

T. Guo, Y. Yan, W. Cao, Q. Liu, H. Zhu et al., Predictive value of microRNA-132 and its target gene NAG-1 in evaluating therapeutic efficacy of non-steroidal anti-inflammatory drugs treatment in patients with ankylosing spondylitis, Clin. Rheumatol, vol.37, pp.1281-1293, 2018.

G. Ciancio, M. Ferracin, E. Saccenti, V. Bagnari, I. Farina et al., Characterisation of peripheral blood mononuclear cell microRNA in early onset psoriatic arthritis, Clin. Exp. Rheumatol, vol.35, pp.113-121, 2017.

J. Sun, M. Feng, F. Wu, X. Ma, J. Lu et al., Plasma miR-26a as a diagnostic biomarker regulates cytokine expression in systemic juvenile idiopathic arthritis, J. Rheumatol, vol.43, pp.1607-1614, 2016.

Y. Kamiya, J. Kawada, Y. Kawano, Y. Torii, S. Kawabe et al., Serum microRNAs as potential biomarkers of juvenile idiopathic arthritis, Clin. Rheumatol, vol.34, pp.1705-1712, 2015.

Y. Tao, Z. Wang, L. Wang, J. Shi, X. Guo et al., Downregulation of miR-106b attenuates inflammatory responses and joint damage in collagen-induced arthritis, Rheumatology, vol.56, pp.1804-1813, 2017.

M. Ammari, J. Presumey, C. Ponsolles, G. Roussignol, C. Roubert et al., Delivery of miR-146a to Ly6Chigh monocytes inhibits pathogenic bone erosion in inflammatory arthritis, Theranostics, vol.8, pp.5972-5985, 2018.

J. Peng, S. Chen, C. Wu, H. Chong, Y. Ding et al., Amelioration of experimental autoimmune arthritis through targeting of synovial fibroblasts by intraarticular delivery of microRNAs 140-3p and 140-5p: delivery of miR140-3p and miR140-5p to treat autoimmune arthritis, Arthritis Rheumatol, vol.68, pp.370-381, 2016.

Y. Nagata, T. Nakasa, Y. Mochizuki, M. Ishikawa, S. Miyaki et al., Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded microRNA-15a, Arthritis Rheum, vol.60, pp.2677-2683, 2009.

Y. Nakamachi, K. Ohnuma, K. Uto, Y. Noguchi, J. Saegusa et al., MicroRNA-124 inhibits the progression of adjuvant-induced arthritis in rats, Ann. Rheum. Dis, vol.75, pp.601-608, 2016.

D. Adams, A. Gonzalez-duarte, W. D. O'riordan, C. Yang, M. Ueda et al., N. Engl. J. Med, vol.379, pp.11-21, 2018.

J. R. Mendell, L. R. Rodino-klapac, Z. Sahenk, K. Roush, L. Bird et al., The eteplirsen Study Group, Eteplirsen for the treatment of duchenne muscular dystrophy: eteplirsen for DMD, Ann. Neurol, vol.74, pp.637-647, 2013.

E. Wong, T. Goldberg, and M. , Pharm. Ther, vol.39, pp.119-122, 2014.

M. Lindow and S. Kauppinen, Discovering the first microRNA-targeted drug, J. Cell Biol, vol.199, pp.407-412, 2012.

C. Chakraborty, A. R. Sharma, G. Sharma, C. G. Doss, and S. Lee, Therapeutic miRNA and siRNA: moving from bench to clinic as next generation medicine, Mol. Ther. Nucl. Acids, vol.8, pp.132-143, 2017.

M. E. Luck, S. A. Muljo, and C. B. Collins, Prospects for therapeutic targeting of microRNAs in human immunological diseases, J. Immunol, vol.194, pp.5047-5052, 2015.

B. Dhungel, C. Ramlogan-steel, and J. Steel, MicroRNA-regulated gene delivery systems for research and therapeutic purposes, Molecules, vol.23, p.1500, 2018.

A. Najm, Biochemical Pharmacology