. Varki-a, E. Cummings-rd, and . Jd, Essentials of Glycobiology, 2009.

P. Takeuchi-y, . Cd, and . Strahan-km, Sensitization of cells and retroviruses to human serum by (al-3) galactosyltransferase, Nature, vol.379, pp.85-88, 1996.

S. E. Varki-nm, D. Ej, . Benirschke-k, and . Varki-a, Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology, Annu Rev Pathol, vol.6, pp.365-393, 2011.

W. Schouten-m, L. M. Wj, and . Van-der-poll-t, Inflammation, endothelium, and coagulation in sepsis, J Leukoc Biol, vol.83, pp.536-545, 2008.

L. E. Oriol-r, M. R. Pendu-j, . Genetics, H. Abo, and . Lewis, Vox Sang, vol.51, pp.161-171, 1986.

C. Dk and K. E. Oriol-r, Oligosaccharides and discordant xenotransplantation, Immunol Rev, vol.141, pp.31-58, 1994.

. Galili-u, The a-gal epitope and the anti-Gal antibody in xenotransplantation and in cancer immunotherapy, Immunol Cell Biol, vol.83, pp.674-686, 2005.

A. M. Robson-sc, B. Esch-js, and . Fh, Factors in xenograft rejection, Ann N Y Acad Sci, vol.875, pp.261-276, 1999.

R. Cowan-pj, D. Sc, and . Ajf, Controlling coagulation dysregulation in xenotransplantation, Curr Opin Organ Transplant, vol.16, pp.214-221, 2011.

. Cozzi-e and . White-dj, The generation of transgenic pigs as potential organ donors for humans, Nat Med, vol.1, pp.964-966, 1995.

M. Galili-u, . Re, S. Hamadeh-rm, G. Sb, and . Jm, Interaction between human natural anti-alpha-galactosyl immunoglobulin G and bacteria of the human flora, Infect Immun, vol.56, pp.1730-1737, 1988.

V. Dai-y, . Td, and . Boone-j, Targeted disruption of the a1,3-galactosyltransferase gene in cloned pigs, Nat Biotechnol, vol.20, pp.251-255, 2002.

. Griesemer-ad, . Hirakata-a, and . Shimizu-a, Results of gal-knockout porcine thymokidney xenografts, Am J Transplant, vol.9, pp.2669-2678, 2009.

Y. Hisashi, . Yamada-k, and . Kuwaki-k, Rejection of cardiac xenografts transplanted from a-1,3-galactosyltransferase gene-knockout (GalT-KO) pigs to baboons, Am J Transplant, vol.8, pp.2516-2526, 2008.

. Kuwaki-k, D. Tseng-y-l, and . Fjmf, Heart transplantation in baboons using a1,3-galactosyltransferase gene-knockout pigs as donors: initial experience, Nat Med, vol.11, pp.29-31, 2005.

. Phelps-cj, C. Koike, and V. Td, Production of a1,3-galactosyltransferase-deficient pigs, Science, vol.299, pp.411-414, 2003.

K. Tseng-y-l and D. Fjmf, 3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months, Transplantation, vol.80, pp.1493-1500, 2005.

. Galili-u, Induced anti-non gal antibodies in human xenograft recipients, Transplantation, vol.93, pp.11-16, 2012.

S. Byrne-gw, . Pg, and . Davila-e, Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation, Xenotransplantation, vol.15, pp.268-276, 2008.

. Zhu-a, Binding of human natural antibodies to non aGal xenoantigens on porcine erythrocytes, Transplantation, vol.69, pp.2422-2428, 2000.

G. B. Ezzelarab-m and A. , The innate immune response and activation of coagulation in a1,3-galactosyltransferase gene-knockout xenograft recipients, Transplantation, vol.87, pp.805-812, 2009.

. Dufrane-d, . Goebbels-r-m, and . Gianello-p, Alginate macroencapsulation of pig islets allows correction of streptozotocin-induced diabetes in primates up to 6 months without immunosuppression, Transplantation, vol.90, pp.1054-1062, 2010.

. Galili-u, . Tibell-a, . Samuelsson-b, L. Rydberg, and . Groth-c, Increased anti-Gal activity in diabetic patients transplanted with fetal porcine islet cell clusters, Transplantation, vol.59, pp.1549-1556, 1995.

. Satake-m, . Kawagishi-n, and . Kumagai-braesch-m, Specificity of human xenoantibodies formed in response to fetal porcine isletlike cell clusters, Transplant Proc, vol.26, p.1122, 1994.

L. E. Vabres-b and R. Bas-bernardet-s, hCTLA4-Ig transgene expression in keratocytes modulates rejection of corneal xenografts in a pig to non-human primate anterior lamellar keratoplasty model, Xenotransplantation, vol.21, pp.431-443, 2014.

. Thompson-p, . Badell-ir, and . Lowe-m, Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function, Am J Transplant, vol.11, pp.2593-2602, 2011.

C. Ch, B. Mirakhur, and C. E. , Cetuximabinduced anaphylaxis and IgE specific for galactosea-1,3-galactose, N Engl J Med, vol.358, pp.1109-1117, 2008.

. Chou-h-h, H. Takematsu, and . Diaz-s, A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence, Proc Natl Acad Sci U S A, vol.95, pp.11751-11756, 1998.

M. Yn and S. L. Schauer-r, The role of CMP-Nacetylneuraminic acid hydroxylase in determining the level of N-glycolylneuraminic acid in porcine tissues, Glycoconj J, vol.15, pp.885-893, 1998.

. Schauer-r, Sialic acids: fascinating sugars in higher animals and man, Zoology, vol.107, pp.49-64, 2004.

N. Bardor-m, . Dh, . Diaz-s, and . Varki-a, Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells, J Biol Chem, vol.280, pp.4228-4237, 2005.

. Tangvoranuntakul-p, P. Gagneux, and . Diaz-s, Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid, Proc Natl Acad Sci U S A, vol.100, pp.12045-12050, 2003.

P. and Y. H. Cao-h, Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: potential implications for disease, Glycobiology, vol.18, pp.818-830, 2008.

. Zhu-a and . Hurst-r, Anti-N-glycolylneuraminic acid antibodies identified in healthy human serum, Xenotransplantation, vol.9, pp.376-381, 2002.

W. Jp, B. Lg, and R. Ma, A human-specific mutation limits nonhuman primate efficacy in preclinical xenotransplantation studies, Transplantation, vol.97, pp.385-390, 2014.

. Miwa-y, . Kobayashi-t, and . Nagasaka-t, Are N-glycolylneuraminic acid (Hanganutziu-Deicher) antigens important in pig-to-human xenotransplantation?, Xenotransplantation, vol.11, pp.247-253, 2004.

. Miyagawa-s, . Ueno-t, H. Nagashima, Y. Takama, and . Fukuzawa-m, Carbohydrate antigens, Curr Opin Organ Transplant, vol.17, pp.174-179, 2012.

. Padler-karavani-v and . Varki-a, Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk, Xenotransplantation, vol.18, pp.1-5, 2011.

Y. Kobayashi-t and . Suzuki-a, Lack of antibody production against Hanganutziu-Deicher (H-D) antigens with N-glycolylneuraminic acid in patients with porcine exposure history, Xenotransplantation, vol.7, pp.177-180, 2000.

B. Bouhours-d and . Jf, Tissue-specific expression of GM3(NeuGc) and GD3(NeuGc) in epithelial cells of the small intestine of strains of inbred rats. Absence of NeuGc in intestine and presence in kidney gangliosides of brown Norway and spontaneously hypertensive rats, J Biol Chem, vol.263, pp.15540-15545, 1988.

. Bouhours-d, . Pourcel-c, and . Bouhours-j-f, Simultaneous expression by porcine aorta endothelial cells of glycosphingolipids bearing the major epitope for human xenoreactive antibodies (Gala1-3Gal), blood group H determinant and N-glycolylneuraminic acid, Glycoconj J, vol.13, pp.947-953, 1996.

A. Diswall-m and . Karlsson-h, Structural characterization of a1,3-galactosyltransferase knockout pig heart and kidney glycolipids and their reactivity with human and baboon antibodies, Xenotransplantation, vol.17, pp.48-60, 2010.

. Omori-t, . Nishida-t, and . Komoda-h, A study of the xenoantigenicity of neonatal porcine islet-like cell clusters (NPCC) and the efficiency of adenovirus-mediated DAF (CD55) expression, Xenotransplantation, vol.13, pp.455-464, 2006.

. Komoda-h, . Miyagawa-s, and . Kubo-t, A study of the xenoantigenicity of adult pig islets cells, Xenotransplantation, vol.11, pp.237-246, 2004.

. Maeda-a, T. Ueno, and . Nakatsu-s, A lectin microarray study of glycoantigens in neonatal porcine islet-like cell clusters, J Surg Res, vol.183, pp.412-418, 2013.

. Cohen-d, Y. Miyagawa, and . Mehra-r, Distribution of non-gal antigens in pig cornea: relevance to corneal xenotransplantation, Cornea, vol.33, pp.390-397, 2014.

. Davies-lrl and . Varki-a, Why is n-glycolylneuraminic acid rare in the vertebrate brain?, Top Curr Chem, 2013.

P. Scobie-l and L. E. Bas-bernardet-s, Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts, J Immunol, vol.191, pp.2907-2915, 2013.

. Naso-f, . Gandaglia-a, and . Bottio-t, First quantification of alpha-Gal epitope in current glutaraldehyde-fixed heart valve bioprostheses, Xenotransplantation, vol.20, pp.252-261, 2013.

O. Park-cs and K. Ye, Anti-alpha-Gal antibody response following xenogeneic heart valve implantation in adults, J Heart Valve Dis, vol.22, pp.222-229, 2013.

A. Stone-kr, W. Um, T. Aw, . Tj, and . Galili-u, Replacement of human anterior cruciate ligaments with pig ligaments: a model for antinon-gal antibody response in long-term xenotransplantation, Transplantation, vol.83, pp.211-219, 2007.

. Manji-ra, M. Ekser-b, C. Ah, and . Dkc, Bioprosthetic heart valves of the future, Xenotransplantation, vol.21, pp.1-10, 2014.

Z. Manji-ra, N. Lf, and . Nk, Glutaraldehydefixed bioprosthetic heart valve conduits calcify and fail from xenograft rejection, Circulation, vol.114, pp.318-327, 2006.

J. , A. M. , P. , K. , and K. , Detection of Hanganutziu-Deicher antigens in O-glycans from pig heart tissues by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, Xenotransplantation, vol.20, pp.407-417, 2013.

. Burlak-c, M. Bern, and . Brito-ae, N-linked glycan profiling of GGTA1/CMAH knockout pigs identifies new potential carbohydrate xenoantigens, Xenotransplantation, vol.20, pp.277-291, 2013.

R. Wormald-mr, H. Pm, and . Dj, Variations in oligosaccharide-protein interactions in immunoglobulin G determine the site-specific glycosylation profiles and modulate the dynamic motion of the Fc oligosaccharides, Biochemistry (Mosc), vol.36, pp.1370-1380, 1997.

R. Pirofsky-b and A. A. Jc, Foreign Serum" heterophile antibodies in patients receiving antithymocyte antisera, Blood, vol.42, pp.385-393, 1973.

G. Se, P. A. Gottlieb, and . Rigby-mr, Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial, Lancet Diabetes Endocrinol, vol.1, pp.306-316, 2013.

. Higashi-h, . Naiki-m, . Matuo-s, and . Okouchi-k, Antigen of "serum sickness" type of heterophile antibodies in human sera: identification as gangliosides with N-glycolylneuraminic acid, Biochem Biophys Res Commun, vol.79, pp.388-395, 1977.

. Merrick-jm, . Zadarlik-k, and . Milgrom-f, Characterization of the Hanganutziu-Deicher (serum-sickness) antigen as gangliosides containing N-glycolylneuraminic acid, Int Arch Allergy Appl Immunol, vol.57, pp.477-480, 1978.

G. Pham-t, . Cj, and . Karp-f, Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium, Blood, vol.114, pp.5225-5235, 2009.

. Ducloux-d, C. Courivaud, and . Bamoulid-j, Polyclonal antithymocyte globulin and cardiovascular disease in kidney transplant recipients, J Am Soc Nephrol, vol.25, pp.1349-1356, 2014.

. Hanganutziu-m, H emagglutinines h et erog en etiques apr es injection de s erum de cheval, CR S eances Soc Biol, vol.91, pp.1457-1459, 1924.

. Kobayashi-t, . Suzuki-a, and . Yokoyama-i, Immunogenicity of Hanganutziu-Deicher antigens in pig-to-human xenotransplantation, Transplant Proc, vol.32, p.874, 2000.

. Blixt-o, T. Kumagai-braesch-m, G. Cg, and . Holgersson-j, Anticarbohydrate antibody repertoires in patients transplanted with fetal pig islets revealed by glycan arrays, Am J Transplant, vol.9, pp.83-90, 2009.

M. Magnusson-s, . Ansson-j-e, and . Strokan-v, Release of pig leukocytes during pig kidney perfusion and characterization of pig lymphocyte carbohydrate xenoantigens, Xenotransplantation, vol.10, pp.432-445, 2003.

G. Banda-k, . Cj, . Chow-r, . Varki-nm, and . Varki-a, Metabolism of vertebrate amino sugars with N-glycolyl groups: mechanisms underlying gastrointestinal incorporation of the non-human sialic acid xeno-autoantigen N-glycolylneuraminic acid, J Biol Chem, vol.287, pp.28852-28864, 2012.

T. Padler-karavani-v and Y. H. Ah, A simple method for assessment of human anti-Neu5Gc antibodies applied to kawasaki disease, PLoS ONE, vol.8, p.58443, 2013.

. Morito-t, . Kano-k, and . Milgrom-f, Hanganutziu-Deicher antibodies in infectious mononucleosis and other diseases, J Immunol, vol.129, pp.2524-2528, 1982.

. Soulillou-j-p, Missing links in multiple sclerosis etiology. A working connecting hypothesis, Med Hypotheses, vol.80, pp.509-516, 2013.

M. Rodr-iguez-zhurbenko-n, . Inez-d, and . Blanco-r, Human antibodies reactive to NeuGcGM3 ganglioside have cytotoxic antitumor properties, Eur J Immunol, vol.43, pp.826-837, 2013.

L. E. Bas-bernardet-s and T. Poirier-n, Xenotransplantation of galactosyl-transferase knockout, CD55, CD59, CD39, and fucosyl-transferase transgenic pig kidneys into baboons, Transplant Proc, vol.43, pp.3426-3430, 2011.

C. Dkc, A brief history of cross-species organ transplantation, Proc (Bayl Univ Med Cent), vol.25, pp.49-57, 2012.

M. Reemtsma-k, . Bh, and . Schlegel-ju, Renal heterotransplantation in man, Ann Surg, vol.160, pp.384-408, 1964.

. Reemtsma-k, Renal heterotransplantation from nonhuman primates to man, Ann N Y Acad Sci, vol.162, pp.412-418, 1969.

M. Starzl-te, P. Tl, and . Gn, Renal heterotransplantation from baboon to man: experience with 6 cases, Transplantation, vol.2, pp.752-776, 1964.

N. Bailey-ll, C. W. Sl, and J. Wb, Baboon-to-human cardiac xenotransplantation in a neonate, JAMA, vol.254, pp.3321-3329, 1985.

. Starzl-te, J. Fung, and . Tzakis-a, Baboon-to-human liver transplantation, Lancet, vol.341, pp.65-71, 1993.

. Michaels-mg, V. Kaufman-c, and . Pa, Baboon bone-marrow xenotransplant in a patient with advanced HIV disease: case report and 8-year follow-up, Transplantation, vol.78, pp.1582-1589, 2004.

F. F. Grabenw-?-oger-m and . Gross-c, Different modes of degeneration in autologous and heterologous heart valve prostheses, J Heart Valve Dis, vol.9, pp.104-109, 2000.

. Loyens-m, . Thuny-f, and . Grisoli-d, Link between endocarditis on porcine bioprosthetic valves and allergy to pork, Int J Cardiol, vol.167, pp.600-602, 2013.

D. Rispens-t, C. Nil, P. Sp, A. Ta, and . Rc, IgE production to a-gal is accompanied by elevated levels of specific IgG1 antibodies and low amounts of IgE to blood group B, PLoS ONE, vol.8, p.55566, 2013.

. Dvor-ankov-a-b, . Broz-l, . Pafcuga-i, K. Kapounkov-a-z, and . Onigov-a-r, The role of skin bank in the treatment of severely burnt patients, Acta Chir Plast, vol.46, pp.51-55, 2004.

H. Tahara, B. Ide-k, and . Nb, Immunological property of antibodies against N-glycolylneuraminic acid epitopes in cytidine monophospho-N-acetylneuraminic acid hydroxylase-deficient mice, J Immunol, vol.184, pp.3269-3275, 2010.

. Kavaler-s, H. Morinaga, and J. , Pancreatic b-cell failure in obese mice with human-like CMP-Neu5Ac hydroxylase deficiency, FASEB J, vol.25, pp.1887-1893, 2011.

. Naito-y, H. Takematsu, and . Koyama-s, Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation, Mol Cell Biol, vol.27, pp.3008-3022, 2007.

. Hedlund-m, . Tangvoranuntakul-p, and . Takematsu-h, N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution, Mol Cell Biol, vol.27, pp.4340-4346, 2007.

L. P. Lutz-aj and E. Jl, Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose a-1,3-Galactose reduce the humoral barrier to xenotransplantation, Xenotransplantation, vol.20, pp.27-35, 2013.

. Conchon-s and C. Perota-a, Generation of CMAH À/À piglets on GAL À/À genetic background (oral communication 8: Tg pigs and animal models), Xenotransplantation, vol.20, pp.368-371, 2013.

L. K. Kwon-d-n and . Kang-m-j, Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs, Sci Rep, vol.3, 1981.

. Martin-mj, . Muotri-a, . Gage-f, and . Varki-a, Human embryonic stem cells express an immunogenic nonhuman sialic acid, Nat Med, vol.11, pp.228-232, 2005.

P. and P. Bui-h-t, 3-galactosyltransferase deficiency in germ-free miniature pigs increases N-glycolylneuraminic acids as the xenoantigenic determinant in pig-human xenotransplantation, Cell Reprogram, vol.14, pp.353-363, 2012.

P. Park-m-r and . Kwon-d-n, Alpha 1,3-galactosyltransferase deficiency in pigs increases sialyltransferase activities that potentially raise non-gal xenoantigenicity, Biomed Res Int, p.560850, 2011.

R. Deschamps-j-y, . Fa, and G. E. Sa-?-i-p, History of xenotransplantation, Xenotransplantation, vol.12, pp.91-109, 2005.

C. Taniguchi-s and . Dk, Clinical xenotransplantation: past, present and future, Ann R Coll Surg Engl, vol.79, pp.13-19, 1997.

. Hitchcock-cr, J. C. Kiser, T. Rl, and S. El, Baboon renal grafts, JAMA, vol.189, pp.934-937, 1964.

M. Reemtsma-k, . Bh, J. U. Schlegel, and . Pearl-m, Heterotransplantation of the kidney: two clinical experiences, Science, vol.143, pp.700-702, 1964.

. Reemtsma-k, Xenotransplantation: a historical perspective, ILAR J, vol.37, pp.9-12, 1995.

R. Dt, V. Kirkpatrick-ch, W. Ae, and . We, Immunologic studies in human organ transplantation. IV. Serologic and pathologic studies following heterotransplantation of the kidney, Am J Pathol, vol.50, pp.605-622, 1967.

. Hume-d, Discussion of reemtsma paper, Ann Surg, vol.160, p.409, 1964.

J. Traeger, D. Fries, and . Perrin-j, Heterotransplantation chez l'homme. Premier r esultats

, Proc Eur Dial Transplant Assoc, vol.2, p.214, 1965.

. Cortesini-r, C. Casciani, and . Cucchiara-g, Heterotransplantation in primates: current state of affairs, Copenhagen: Munksgaard, p.239, 1969.

R. Ag, C. Dk, P. A. Human, H. Reichenspurner, and . Reichart-b, Histopathology of hyperacute rejection of the heart: experimental and clinical observations in allografts and xenografts, J Heart Lung Transplant, vol.10, pp.223-234, 1991.