Potential deleterious role of anti-Neu5Gc antibodies in xenotransplantation

Abstract : Human beings do not synthesize the glycolyl form of the sialic acid (Neu5Gc) and only express the acetylated form of the sugar, whereas a diet-based intake of Neu5Gc provokes a natural immunization and production of anti-Neu5Gc antibodies in human serum. However , Neu5Gc is expressed on mammal glycoproteins and glycolipids in most organs and cells. We review here the relevance of Neu5Gc and anti-Neu5Gc antibodies in the context of xenotransplantation and the use of animal-derived molecules and products, as well as the possible consequences of a long-term exposure to anti-Neu5Gc antibodies in recipients of xenografts. In addition, the importance of an accurate estimation of the anti-Neu5Gc response following xenotransplantation and the future contribution of knockout animals mimicking the human situation are also assessed.
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Apolline Salama, Gwénaëlle Evanno, Jean Harb, Jean-Paul Soulillou. Potential deleterious role of anti-Neu5Gc antibodies in xenotransplantation. Xenotransplantation, Wiley, 2015, 22 (2), pp.85-94. ⟨10.1111/xen.12142⟩. ⟨inserm-02147779⟩

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