Two subsets of memory T lymphocytes with distinct homing potentials and effector functions, Nature, vol.401, pp.708-720, 1999. ,
Phenotype and function of human T lymphocyte subsets: consensus and issues, Cytometry A, vol.73, pp.975-83, 2008. ,
The Warburg effect: evolving interpretations of an established concept, Free Radic Biol Med, vol.79, pp.253-63, 2015. ,
The chemical constitution of respiration ferment, Science, vol.68, pp.437-480, 1928. ,
Metabolic regulation of T lymphocytes, Annu Rev Immunol, vol.31, pp.259-83, 2013. ,
Cellular energy metabolism in T-lymphocytes, Int Rev Immunol, vol.34, issue.1, pp.34-49, 2015. ,
Metabolic changes in activated T cells: an NMR study of human peripheral blood lymphocytes, Magn Reson Med, vol.29, issue.3, pp.317-343, 1993. ,
Understanding the Warburg effect: the metabolic requirements of cells proliferation, Science, vol.324, issue.5930, pp.1029-1062, 2009. ,
Integrating canonical and metabolic signalling programmes in the regulation of T cell responses, Nat Rev Immunol, vol.14, issue.7, pp.435-481, 2014. ,
Kidney transplantation: mechanisms of rejection and acceptance, Annu Rev Pathol, vol.3, pp.189-220, 2008. ,
Role of T cells in graft rejection and transplantation tolerance, Exp Rev Clin Immunol, vol.6, issue.1, pp.155-69, 2010. ,
The role of CD8 + T cells during allograft rejection, Braz J Med Biol Res, vol.35, pp.1247-58, 2002. ,
Mechanisms of rejection: current perspectives, Transplantation, vol.93, issue.1, p.1, 2012. ,
Renal allograft rejection -in situ demonstration of cytotoxic intratubular cells, Transplantation, issue.10, pp.1546-1555, 1996. ,
An essential contribution by IFN-gamma to CD8+ T cell-mediated rejection of pancreatic islet allografts, J Immunol, vol.165, issue.1, pp.247-55, 2000. ,
Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates, Am J Transplant, vol.12, issue.2, pp.330-370, 2012. ,
Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft, Am J Transplant, vol.7, pp.1055-61, 2007. ,
Terminally differentiated CD8+ Temra cells are associated with the risk for acute kidney allograft rejection, Transplantation, vol.94, issue.1, pp.63-72, 2012. ,
Phenotypically and functionally distinct CD8+ lymphocyte populations in long-term drugfree tolerance and chronic rejection in human kidney graft recipients, J Am Soc Nephrol, vol.17, pp.294-304, 2006. ,
Increased numbers of circulating CD8 effector memory T cells before transplantation enhance the risk of acute rejection in lung transplant recipients, PLoS One, vol.8, issue.11, p.80601, 2013. ,
A higher risk of acute rejection of human kidney allografts can be predicted from the level of CD45RC expressed by the recipients' CD8 T cells, PLoS One, vol.8, issue.7, p.69791, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-02164657
Expansion of highly differentiated cytotoxic terminally differentiated effector memory CD8+ T cells in a subset of clinically stable kidney transplant recipients: a potential marker for late graft dysfunction, J Am Soc Nephrol, vol.25, issue.8, pp.1856-68, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-02163547
Advances on non-CD4 + Foxp3+ T regulatory cells, Transplantation, issue.8, p.1, 2015. ,
Detection of T suppressor cells in patients with organ allografts, Hum Immunol, vol.62, issue.00, pp.15-20, 2001. ,
MHC-derived allopeptide activates TCR-biased CD8+ tregs and suppresses organ rejection, J Clin Invest, vol.124, issue.6, pp.2497-512, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-02167782
Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation, Blood, vol.104, issue.10, pp.3294-301, 2009. ,
CD8+CD45RA+CCR7+FOXP3+ T cells with immunosuppressive properties: a novel subset of inducible human regulatory T cells, J Immunol, vol.189, issue.5, 2012. ,
The protective effect of CD8+CD28-T suppressor cells on the acute rejection responses in rat liver transplantation, Transplant Proc, vol.39, issue.10, pp.3396-403, 2007. ,
A significant expansion of CD8+ CD28-T-suppressor cells in adult-to-adult living donor liver transplant recipients, Transplant Proc, issue.10, pp.4229-4260, 2009. ,
Mechanism and localization of CD8 regulatory T cells in a heart transplant model of tolerance, J Immunol, vol.185, issue.2, pp.823-856, 2010. ,
The role of the crabtree effect and an endogenous fuel in the energy metabolism of resting and proliferating thymocytes ,
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival, Eur J Biochem, vol.212, issue.1, pp.2101-2112, 1993. ,
Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors, Immunity, vol.10, issue.5, pp.525-560, 1999. ,
,
PI3K signaling pathways have both common and distinct roles in IL-7-mediated activities in human CD8+ T cells, J Leukoc Biol, vol.95, issue.1, pp.117-144, 2014. ,
Fatty acid metabolism in the regulation of T cell function, Trends Immunol, vol.36, issue.2, pp.81-91, 2015. ,
Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development, Immunity, vol.41, issue.1, pp.75-88, 2014. ,
Enhancing CD8 T-cell memory by modulating fatty acid metabolism, Nature, vol.460, issue.7251, pp.103-110, 2009. ,
IL-7-induced glycerol transport and TAG synthesis promotes memory CD8(+) T cell longevity, Cell, vol.161, issue.4, pp.750-61, 2015. ,
mTOR regulates memory CD8 T-cell differentiation, Nature, vol.460, issue.7251, pp.108-120, 2009. ,
Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation, Metabolism, vol.55, issue.12, pp.1637-1681, 2006. ,
MTOR, linking metabolism and immunity, Semin Immunol, vol.24, issue.6, pp.429-464, 2012. ,
The role of mTOR in memory CD8+ T-cell differentiation, Immunol Rev, vol.235, issue.1, pp.234-277, 2010. ,
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation, Annu Rev Cell Dev Biol, vol.27, issue.1, pp.441-64, 2011. ,
The CD28 signaling pathway regulates glucose metabolism, Immunity, vol.16, issue.6, pp.769-77, 2002. ,
Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways, J Immunol, vol.180, issue.7, pp.4476-86, 2008. ,
Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B, Eur J Immunol, vol.27, issue.10, pp.2495-501, 1997. ,
Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch, Nat Immunol, vol.14, issue.10, pp.1064-72, 2013. ,
Posttranscriptional control of T cell effector function by aerobic glycolysis, Cell, vol.153, issue.6, pp.1239-51, 2013. ,
CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability, Proc Natl Acad Sci U S A, vol.110, issue.35, pp.14336-14377, 2013. ,
Glutamine uptake and metabolism are coordinately regulated by ERK/ MAPK during T lymphocyte activation, J Immunol, vol.185, issue.2, pp.1037-1081, 2010. ,
Metabolic switching and fuel choice during T-cell differentiation and memory development, Immunol Rev, vol.249, issue.1, pp.27-42, 2012. ,
Lymphocyte glucose and glutamine metabolism as targets of the anti-inflammatory and immunomodulatory effects of exercise, Mediators Inflamm, vol.2014, pp.1-10, 2014. ,
Targeting T cell metabolism for therapy, Trends Immunol, vol.36, issue.2, 2015. ,
Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells, J Immunol, vol.174, issue.8, pp.4670-4677, 2005. ,
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function, J Clin Invest, vol.123, issue.10, pp.4479-88, 2013. ,
The transcription factor myc controls metabolic reprogramming upon T lymphocyte activation, Immunity, vol.35, issue.6, pp.871-82, 2011. ,
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation, Nat Immunol, vol.14, issue.5, pp.500-508, 2013. ,
Warburg phenotype in renal cell carcinoma: high expression of glucose-transporter 1 (GLUT-1) correlates with low CD8+ T-cell infiltration in the tumor, Int J Cancer, vol.128, issue.9, pp.2085-95, 2011. ,
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses, Science, vol.334, issue.6060, pp.1278-83, 2011. ,
The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function, Cell Metab, vol.20, issue.1, pp.61-72, 2014. ,
Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide -mechanisms independent of pyrimidine depletion, J Leukoc Biol, vol.76, issue.5, pp.950-60, 2004. ,
Randomized trial of oral teriflunomide for relapsing multiple sclerosis, N Engl J Med, vol.365, issue.14, pp.1293-303, 2011. ,
Long-term allograft tolerance is characterized by the accumulation of B cells exhibiting an inhibited profile, Am J Transplant, vol.11, issue.3, pp.429-467, 2011. ,
The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo, Immunity, vol.42, issue.1, pp.41-54, 2015. ,
Normalization of CD4 + T cell metabolism reverses lupus, Sci Transl Med, vol.7, issue.274, pp.1-13, 2015. ,
Regulation of T lymphocyte metabolism, J Immunol, vol.172, issue.8, pp.4661-4666, 2004. ,
Antagonist properties of monoclonal antibodies targeting human CD28, MAbs, vol.5, issue.1, pp.47-55, 2013. ,
Preclinical efficacy and immunological safety of FR104, an antagonist anti-CD28 monovalent fab? antibody, Am J Transplant, vol.12, issue.10, pp.2630-2670, 2012. ,
URL : https://hal.archives-ouvertes.fr/inserm-02167934
FR104, an antagonist anti-CD28 monovalent fab? antibody, prevents alloimmunization and allows calcineurin inhibitor minimization in nonhuman primate renal allograft, Am J Transplant, vol.15, issue.1, pp.88-100, 2015. ,
URL : https://hal.archives-ouvertes.fr/inserm-02148443
Inhibiting the Akt pathway in cancer treatment: three leading candidates, P T, vol.36, issue.4, pp.225-232, 2011. ,
Akt1 and -2 inhibition diminishes terminal differentiation and enhances central memory CD8 ,
, , vol.4, 2015.
Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis, Adv Drug Deliv Rev, vol.63, issue.8, pp.610-615, 2011. ,
High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma, Cancer Res, vol.73, issue.9, pp.2873-83, 2013. ,
Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy, Blood, vol.124, issue.23, pp.3490-500, 2014. ,
Regulatory T-cell therapy in the induction of transplant tolerance: the issue of subpopulations, Transplantation, vol.98, issue.4, pp.370-379, 2014. ,
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast, Science, vol.253, issue.5022, pp.905-914, 1991. ,
A mammalian protein targeted by G1-arresting rapamycin-receptor complex, Nature, vol.369, issue.6483, pp.756-764, 1994. ,
mTOR signaling at a glance, J Cell Sci, pp.3589-94, 2009. ,
Regulation of mTORC1 and its impact on gene expression at a glance, J Cell Sci, pp.1713-1722, 2013. ,
Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth, J Biol Chem, issue.49, pp.37372-80, 2006. ,
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth, Cell Metab, vol.8, issue.3, pp.224-260, 2008. ,
Sirolimus: its discovery, biological properties, and mechanism of action, Transplant Proc, vol.35, issue.3, pp.211-213, 2003. ,
Immunosuppressive drugs for kidney transplantation, N Engl J Med, vol.351, pp.2715-2745, 2004. ,
Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients, J Immunol, vol.177, issue.12, pp.8338-8385, 2006. ,
Rapamycin generates graft-homing murine suppressor CD8+ T cells that confer donor-specific graft protection, Cell Transplant, vol.20, pp.1759-69, 2011. ,
Alloanergization of human T cells results in expansion of alloantigen-specific CD8(+) CD28(-) suppressor cells, Am J Transplant, vol.14, pp.305-323, 2014. ,