Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Liraglutide in whole-pancreas transplant patients with impaired glucose homoeostasis: A case series

Abstract : Hyperglycaemia may develop after whole-pancreas transplantation (PTX) in patients with type 1 diabetes mellitus (T1DM), but the efficacy and tolerability of GLP-1 receptor agonists have not been assessed in this population. This report is a 6-month prospective follow-up of six T1DM recipients of PTX (mean time after PTX: 68.8 ± 45.7 months), all of whom had an HbA 1c > 6.5% (48 mmol/mol) [mean: 7.1% (54 mmol/mol)] after initiation of liraglutide alone at 0.6 mg once daily titrated to 1.2 mg once daily at week 1. Gastrointestinal disorders were reported in three of the six patients, with discontinuation of liraglutide in only one patient. HbA 1c improved in the five remaining patients, with a median decrease of 0.8% (0.0-2.7%) at 6 months, and the median decrease in body weight was 2.0 kg. Immunosuppressive treatments remained unchanged with liraglutide. Thus, liraglutide appears to be an effective and well-tolerated option in PTX patients with impaired glucose homoeostasis, regardless of the cause.
Document type :
Journal articles
Complete list of metadata

Cited literature [7 references]  Display  Hide  Download
Contributor : Sylvie Le Bihan Connect in order to contact the contributor
Submitted on : Tuesday, June 4, 2019 - 2:26:08 PM
Last modification on : Wednesday, April 27, 2022 - 4:06:42 AM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Bertrand Cariou, C. Bernard, D. Cantarovich. Liraglutide in whole-pancreas transplant patients with impaired glucose homoeostasis: A case series. Journal of Diabetes & Metabolism, OMICS International, 2015, 41 (3), pp.252-257. ⟨10.1016/j.diabet.2014.10.004⟩. ⟨inserm-02147105⟩



Record views