I. R. Hamilton, Ecological basis for dental caries, " in Oral Bacterial Ecology: The Molecular Basis, pp.219-274, 2000.

J. Farges, J. Keller, and F. Carrouel, Odontoblasts in the dental pulp immune response, Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, vol.312, issue.5, pp.425-436, 2009.

R. M. Love and H. F. Jenkinson, Invasion of dentinal tubules by oral bacteria, Critical Reviews in Oral Biology and Medicine, vol.13, issue.2, pp.171-183, 2002.

P. R. Cooper, J. L. Mclachlan, S. Simon, L. W. Graham, and A. J. Smith, Mediators of inflammation and regeneration, Advances in dental research, vol.23, issue.3, pp.290-295, 2011.

K. J. Heyeraas and E. Berggreen, Interstitial fluid pressure in normal and inflamed pulp, Critical Reviews in Oral Biology and Medicine, vol.10, issue.3, pp.328-336, 1999.

C. Hahn and F. R. Liewehr, Innate immune responses of the dental pulp to caries, Journal of Endodontics, vol.33, issue.6, pp.643-651, 2007.

H. Lesot, A. J. Smith, D. Tziafas, C. Begue-kirn, N. Cassidy et al., Biologically active molecule and dental tissue repair, a comparative review of reactionary and reparative dentinogenesis with induction of odontoblast differentiation in vitro, Cells and Materials, vol.4, issue.3, pp.199-218, 1994.

J. Farges, B. Alliot-licht, C. Baudouin, P. Msika, F. Bleicher et al., Odontoblast control of dental pulp inflammation triggered by cariogenic bacteria, Frontiers in Physiology, vol.4, p.326, 2013.

P. R. Cooper, M. J. Holder, and A. J. Smith, Inflammation and regeneration in the dentin-pulp complex: a double-edged sword, Journal of Endodontics, vol.40, issue.4, pp.46-51, 2014.

A. Gaudin, E. Renard, and M. Hill, Phenotypic analysis of immunocompetent cells in healthy human dental pulp, Journal of Endodontics, vol.41, issue.5, pp.621-627, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02132075

J. L. Mclachlan, A. J. Smith, I. J. Bujalska, and P. R. Cooper, Gene expression profiling of pulpal tissue reveals the molecular complexity of dental caries, Biochimica et Biophysica Acta, vol.1741, issue.3, pp.271-281, 2005.

S. H. Durand, V. Flacher, and A. Roméas, Lipoteichoic acid increases TLR and functional chemokine expression while reducing dentin formation in in vitro differentiated human odontoblasts, The Journal of Immunology, vol.176, issue.5, pp.2880-2887, 2006.

O. Veerayutthwilai, M. R. Byers, T. T. Pham, R. P. Darveau, and B. A. Dale, Differential regulation of immune responses by odontoblasts, Oral Microbiology and Immunology, vol.22, issue.1, pp.5-13, 2007.

B. A. Beutler, Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases, Immunological Reviews, vol.227, issue.1, pp.248-263, 2009.

T. Kawai and S. Akira, The role of pattern-recognition receptors in innate immunity: update on toll-like receptors, Nature Immunology, vol.11, issue.5, pp.373-384, 2010.

H. Kumar, T. Kawai, and S. Akira, Pathogen recognition by the innate immune system, International Reviews of Immunology, vol.30, issue.1, pp.16-34, 2011.

H. Jiang, W. Zhang, B. Ren, J. Zeng, and J. Ling, Expression of toll like receptor 4 in normal human odontoblasts and dental pulp tissue, Journal of Endodontics, vol.32, issue.8, pp.747-751, 2006.

A. Viola and A. D. Luster, Chemokines and their receptors: drug targets in immunity and inflammation, Annual Review of Pharmacology and Toxicology, vol.48, pp.171-197, 2008.

M. D. Turner, B. Nedjai, T. Hurst, and D. J. Pennington, Cytokines and chemokines: at the crossroads of cell signalling and inflammatory disease, Biochimica et Biophysica ActaMolecular Cell Research, vol.1843, issue.11, pp.2563-2582, 2014.

M. Pazgier, D. M. Hoover, D. Yang, W. Lu, and J. Lubkowski, Human beta-defensins, Cellular and Molecular Life Sciences, vol.63, issue.11, pp.1294-1313, 2006.

O. E. Sørensen, N. Borregaard, and A. M. Cole, Antimicrobial peptides in innate immune responses, Contributions to Microbiology, vol.15, pp.61-77, 2008.

F. Semple and J. R. Dorin, Defensins: multifunctional modulators of infection, inflammation and more?, Journal of Innate Immunity, vol.4, issue.4, pp.337-348, 2012.

S. C. Mansour, O. M. Pena, and R. E. Hancock, Host defense peptides: front-line immunomodulators, Trends in Immunology, vol.35, issue.9, pp.443-450, 2014.

H. Shiba, Y. Mouri, and H. Komatsuzawa, Macrophage inflammatory protein-3alpha and beta-defensin-2 stimulate dentin sialophosphoprotein gene expression in human pulp cells, Biochemical and Biophysical Research Communications, vol.306, issue.4, pp.867-871, 2003.

W. Song, Y. Shi, and M. Xiao, In vitro bactericidal activity of recombinant human -defensin-3 against pathogenic bacterial strains in human tooth root canal, International Journal of Antimicrobial Agents, vol.33, issue.3, pp.237-243, 2009.

S. Lee and D. Baek, Antibacterial and neutralizing effect of human -defensins on Enterococcus faecalis and Enterococcus 12 Mediators of Inflammation faecalis lipoteichoic acid, Journal of Endodontics, vol.38, issue.3, pp.351-356, 2012.

J. Lee, S. W. Chang, and H. Perinpanayagam, Antibacterial efficacy of a human -defensin-3 peptide on multispecies biofilms, Journal of Endodontics, vol.39, issue.12, pp.1625-1629, 2013.

H. Dommisch, J. Winter, C. Willebrand, J. Eberhard, and S. Jepsen, Immune regulatory functions of human beta-defensin-2 in odontoblast-like cells, International Endodontic Journal, vol.40, issue.4, pp.300-307, 2007.

Y. Kim, K. Min, S. Lee, S. Shin, K. Shin et al., Effect of proinflammatory cytokines on the expression and regulation of human beta-defensin 2 in human dental pulp cells, Journal of Endodontics, vol.36, issue.1, pp.64-69, 2010.

S. Lee, K. Min, and W. Bae, Role of SIRT1 in heat stressand lipopolysaccharide-induced immune and defense gene expression in human dental pulp cells, Journal of Endodontics, vol.37, issue.11, pp.1525-1530, 2011.

H. Dommisch, J. Winter, Y. Açil, A. Dunsche, M. Tiemann et al., Human -defensin (hBD-1, -2) expression in dental pulp, Oral Microbiology and Immunology, vol.20, issue.3, pp.163-166, 2005.

S. Paris, M. Wolgin, A. M. Kielbassa, A. Pries, and A. Zakrzewicz, Gene expression of human beta-defensins in healthy and inflamed human dental pulps, Journal of Endodontics, vol.35, issue.4, pp.520-523, 2009.

C. Nathan, Nitric oxide as a secretory product of mammalian cells, The FASEB Journal, vol.6, issue.12, pp.3051-3064, 1992.

A. K. Nussler and T. R. Billiar, Inflammation, immunoregulation, and inducible nitric oxide synthase, Journal of Leukocyte Biology, vol.54, issue.2, pp.171-178, 1993.

J. Macmicking, Q. Xie, and C. Nathan, Nitric oxide and macrophage function, Annual Review of Immunology, vol.15, pp.323-350, 1997.

J. W. Coleman, Nitric oxide in immunity and inflammation, International Immunopharmacology, vol.1, issue.8, pp.1397-1406, 2001.

T. J. Guzik, R. Korbut, and T. Adamek-guzik, Nitric oxide and superoxide in inflammation and immune regulation, Journal of Physiology and Pharmacology, vol.54, issue.4, pp.469-487, 2003.

J. S. Arthur and S. C. Ley, Mitogen-activated protein kinases in innate immunity, Nature Reviews Immunology, vol.13, issue.9, pp.679-692, 2013.

C. Bogdan, Nitric oxide synthase in innate and adaptive immunity: an update, Trends in Immunology, vol.36, issue.3, pp.161-178, 2015.

A. S. Law, K. R. Baumgardner, S. T. Meiler, and G. F. Gebhart, Localization and changes in NADPH-diaphorase reactivity and nitric oxide synthase immunoreactivity in rat pulp following tooth preparation, Journal of Dental Research, vol.78, issue.10, pp.1585-1595, 1999.

F. D. Di-maio, Z. Lohinai, and C. , Nitric oxide synthase in healthy and inflamed human dental pulp, Journal of Dental Research, vol.83, issue.4, pp.312-316, 2004.

H. N. Kawanishi, N. Kawashima, N. Suzuki, H. Suda, and M. Takagi, Effects of an inducible nitric oxide synthase inhibitor on experimentally induced rat pulpitis, European Journal of Oral Sciences, vol.112, issue.4, pp.332-337, 2004.

N. Kawashima, H. Nakano-kawanishi, N. Suzuki, M. Takagi, and H. Suda, Effect of NOS inhibitor on cytokine and COX2 expression in rat pulpitis, Journal of Dental Research, vol.84, issue.8, pp.762-767, 2005.

Y. Korkmaz, H. Lang, and T. Beikler, Irreversible inflammation is associated with decreased levels of the alpha1-, beta1-, and alpha2-subunits of sGC in human odontoblasts, Journal of Dental Research, vol.90, issue.4, pp.517-522, 2011.

K. Min, H. Kim, and H. Chang, Involvement of mitogen-activated protein kinases and nuclear factor-kappa B activation in nitric oxide-induced interleukin-8 expression in human pulp cells, Oral Radiology and Endodontology, vol.105, issue.5, pp.654-660, 2008.

L. S. Silva-mendez, R. P. Allaker, J. M. Hardie, and N. Benjamin, Antimicrobial effect of acidified nitrite on cariogenic bacteria, Oral Microbiology and Immunology, vol.14, issue.6, pp.391-392, 1999.

J. C. Farges, A. Bellanger, and M. Ducret, Human odontoblastlike cells produce nitric oxide with antibacterial activity upon TLR2 activation, Frontiers in Physiology, vol.6, p.185, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02132073

M. Staquet, S. H. Durand, and E. Colomb, Different roles of odontoblasts and fibroblasts in immunity, Journal of Dental Research, vol.87, issue.3, pp.256-261, 2008.

J. Farges, F. Carrouel, and J. Keller, Cytokine production by human odontoblast-like cells upon Toll-like receptor-2 engagement, Immunobiology, vol.216, issue.4, pp.513-517, 2011.

J. Keller, F. Carrouel, and E. Colomb, Toll-like receptor 2 activation by lipoteichoic acid induces differential production of pro-inflammatory cytokines in human odontoblasts, dental pulp fibroblasts and immature dendritic cells, Immunobiology, vol.215, issue.1, pp.53-59, 2010.

J. Keller, F. Carrouel, and M. Staquet, Expression of NOD2 is increased in inflamed human dental pulps and lipoteichoic acid-stimulated odontoblast-like cells, Innate Immunity, vol.17, issue.1, pp.29-34, 2010.

J. Farges, A. Romeas, and M. Melin, TGF-beta1 induces accumulation of dendritic cells in the odontoblast layer, Journal of Dental Research, vol.82, issue.8, pp.652-656, 2003.

M. Jontell, T. Okiji, U. Dahlgren, and G. Bergenholtz, Immune defense mechanisms of the dental pulp, Critical Reviews in Oral Biology and Medicine, vol.9, issue.2, pp.179-200, 1998.

C. A. Hunter and S. A. Jones, IL-6 as a keystone cytokine in health and disease, Nature Immunology, vol.16, issue.5, pp.448-457, 2015.

L. Nibali, S. Fedele, F. D'-aiuto, and N. Donos, Interleukin-6 in oral diseases: a review, Oral Diseases, vol.18, issue.3, pp.236-243, 2012.

M. O. Li and R. A. Flavell, Contextual regulation of inflammation: a duet by transforming growth factor-and interleukin-10, Immunity, vol.28, issue.4, pp.468-476, 2008.

M. Saraiva and A. O'garra, The regulation of IL-10 production by immune cells, Nature Reviews Immunology, vol.10, issue.3, pp.170-181, 2010.

R. Kaji, J. Kiyoshima-shibata, M. Nagaoka, M. Nanno, and K. Shida, Bacterial teichoic acids reverse predominant IL-12 production induced by certain Lactobacillus strains into predominant IL-10 production via TLR2-dependent ERK activation in macrophages, The Journal of Immunology, vol.184, issue.7, pp.3505-3513, 2010.

L. Bjørndal and I. A. Mjör, Pulp-dentin biology in restorative dentistry. Part 4: dental caries-characteristics of lesions and pulpal reactions, Quintessence International, vol.32, issue.9, pp.717-736, 2001.

C. C. Lee, A. M. Avalos, and H. L. Ploegh, Accessory molecules for Toll-like receptors and their function, Nature Reviews Immunology, vol.12, issue.3, pp.168-179, 2012.

M. M. Wurfel, E. Hailman, and S. D. Wright, Soluble CD14 acts as a shuttle in the neutralization of lipopolysaccharide (LPS) by LPS-binding protein and reconstituted high density lipoprotein, The Journal of Experimental Medicine, vol.181, issue.5, pp.1743-1754, 1995.

F. Carrouel, M. Staquet, and J. Keller, Lipopolysaccharide-binding protein inhibits toll-like receptor 2 activation by lipoteichoic acid in human odontoblast-like cells, Journal of Endodontics, vol.39, issue.8, pp.1008-1014, 2013.

C. Mangkornkarn, J. C. Steiner, R. Bohman, and R. A. Lindemann, Flow cytometric analysis of human dental pulp tissue, Journal of Endodontics, vol.17, issue.2, pp.49-53, 1991.

T. Izumi, I. Kobayashi, K. Okamura, and H. Sakai, Immunohistochemical study on the immunocompetent cells of the pulp in human non-carious and carious teeth, Archives of Oral Biology, vol.40, issue.7, pp.609-614, 1995.

C. Hahn and F. R. Liewehr, Update on the adaptive immune responses of the dental pulp, Journal of Endodontics, vol.33, issue.7, pp.773-781, 2007.

P. R. Cooper, Y. Takahashi, L. W. Graham, S. Simon, S. Imazato et al., Inflammation-regeneration interplay in the dentine-pulp complex, Journal of Dentistry, vol.38, issue.9, pp.687-697, 2010.

T. Okiji, M. Jontell, P. Belichenko, G. Bergenholtz, and A. Dahlström, Perivascular dendritic cells of the human dental pulp, Acta Physiologica Scandinavica, vol.159, issue.2, pp.163-169, 1997.

A. K. Abbas, The control of T cell activation vs. tolerance, Autoimmunity Reviews, vol.2, issue.3, pp.115-118, 2003.

S. K. Bedoya, B. Lam, K. Lau, and J. Larkin, Th17 cells in immunity and autoimmunity, vol.2013, 2013.

H. Eba, Y. Murasawa, and K. Iohara, The anti-inflammatory effects of matrix metalloproteinase-3 on irreversible pulpitis of mature erupted teeth, PLoS ONE, vol.7, issue.12, 2012.

N. Kawashima, I. Wongyaofa, N. Suzuki, H. N. Kawanishi, and H. Suda, NK and NKT cells in the rat dental pulp tissues, Oral Radiology and Endodontology, vol.102, issue.4, pp.558-563, 2006.

K. Onoé, Y. Yanagawa, K. Minami, N. Iijima, and K. Iwabuchi, Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells, Immunologic Research, vol.38, issue.1-3, pp.319-332, 2007.

C. Hahn, W. A. Falkler, and M. A. Siegel, A study of T and B cells in pulpal pathosis, Journal of Endodontics, vol.15, issue.1, pp.20-26, 1989.

A. Angelova, Y. Takagi, T. Okiji, T. Kaneko, and Y. Yamashita, Immunocompetent cells in the pulp of human deciduous teeth, Archives of Oral Biology, vol.49, issue.1, pp.29-36, 2004.

J. Bayry, S. Lacroix-desmazes, M. D. Kazatchkine, O. Hermine, D. F. Tough et al., Modulation of dendritic cell maturation and function by B lymphocytes, Journal of Immunology, vol.175, issue.1, pp.15-20, 2005.

T. Tanoue, Y. Umesaki, and K. Honda, Immune responses to gut microbiota-commensals and pathogens, Gut Microbes, vol.1, issue.4, pp.224-233, 2010.
DOI : 10.4161/gmic.1.4.12613

URL : http://europepmc.org/articles/pmc3023604?pdf=render

J. Banchereau and R. M. Steinman, Dendritic cells and the control of immunity, Nature, vol.392, issue.6673, pp.245-252, 1998.

A. E. Morelli and A. W. Thomson, Tolerogenic dendritic cells and the quest for transplant tolerance, Nature Reviews Immunology, vol.7, issue.8, pp.610-621, 2007.

H. Li and B. Shi, Tolerogenic dendritic cells and their applications in transplantation, Cellular and Molecular Immunology, vol.12, issue.1, pp.24-30, 2015.

J. Zhu, H. Yamane, and W. E. Paul, Differentiation of effector CD4

+. Populations, Annual Review of Immunology, vol.28, pp.445-489, 2010.

K. F. Bruno, J. A. Silva, T. A. Silva, A. C. Batista, A. H. Alencar et al., Characterization of inflammatory cell infiltrate in human dental pulpitis, International Endodontic Journal, vol.43, issue.11, pp.1013-1021, 2010.

C. Chauveau, S. Rémy, and P. J. Royer, Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression, Blood, vol.106, issue.5, pp.1694-1702, 2005.
DOI : 10.1182/blood-2005-02-0494

URL : http://www.bloodjournal.org/content/106/5/1694.full.pdf

D. I. Gabrilovich and S. Nagaraj, Myeloid-derived suppressor cells as regulators of the immune system, Nature Reviews Immunology, vol.9, issue.3, pp.162-174, 2009.

A. Dugast, T. Haudebourg, and F. Coulon, Myeloid-derived suppressor cells accumulate in kidney allograft tolerance and specifically suppress effector T cell expansion, Journal of Immunology, vol.180, issue.12, pp.7898-7906, 2008.

L. Drujont, L. Carretero-iglesia, and L. Bouchet-delbos, Evaluation of the therapeutic potential of bone marrow-derived myeloid suppressor cell (MDSC) adoptive transfer in mouse models of autoimmunity and allograft rejection, Article ID e100013, vol.9, 2014.

V. De-wilde, N. Van-rompaey, and M. Hill, Endotoxininduced myeloid-derived suppressor cells inhibit alloimmune responses via heme oxygenase-1, American Journal of Transplantation, vol.9, issue.9, pp.2034-2047, 2009.

J. Jernvall and I. Thesleff, Reiterative signaling and patterning during mammalian tooth morphogenesis, Mechanisms of Development, vol.92, issue.1, pp.19-29, 2000.

L. Bjørndal, The caries process and its effect on the pulp the science is changing and so is our understanding, Journal of Endodontics, vol.34, issue.7, pp.2-5, 2008.

L. Bjørndal and T. Darvann, A light microscopic study of odontoblastic and non-odontoblastic cells involved in tertiary dentinogenesis in well-defined cavitated carious lesions, Caries Research, vol.33, issue.1, pp.50-60, 1999.

A. J. Smith, N. Cassidy, H. Perry, C. Begue-kirn, J. Ruch et al., Reactionary dentinogenesis, International Journal of Developmental Biology, vol.39, issue.1, pp.273-280, 1995.

S. R. Simon, A. Berdal, P. R. Cooper, P. J. Lumley, P. L. Tomson et al., Dentin-pulp complex regeneration: from lab to clinic, Advances in Dental Research, vol.23, issue.3, pp.340-345, 2011.

A. J. Smith, B. A. Scheven, Y. Takahashi, J. L. Ferracane, R. M. Shelton et al., Dentine as a bioactive extracellular matrix, Archives of Oral Biology, vol.57, issue.2, pp.109-121, 2012.

J. L. Mclachlan, A. J. Sloan, A. J. Smith, G. Landini, and P. R. Cooper, S100 and cytokine expression in caries, Infection and Immunity, vol.72, issue.7, pp.4102-4108, 2004.

S. Hosoya, K. Matsushima, E. Ohbayashi, M. Yamazaki, Y. Shibata et al., Stimulation of interleukin-1beta-independent interleukin-6 production in human dental Mediators of Inflammation pulp cells by lipopolysaccharide, Biochemical and Molecular Medicine, vol.59, issue.2, pp.138-143, 1996.

T. Matsuo, S. Ebisu, T. Nakanishi, K. Yonemura, Y. Harada et al., Interleukin-1 and interleukin-1 in periapical exudates of infected root canals: correlations with the clinical findings of the involved teeth, Journal of Endodontics, vol.20, issue.9, pp.432-435, 1994.

S. Pezelj-ribaric, I. Anic, I. Brekalo, I. Miletic, M. Hasan et al., Detection of tumor necrosis factor alpha in normal and inflamed human dental pulps, Archives of Medical Research, vol.33, issue.5, pp.482-484, 2002.

V. S. Lara, F. Figueiredo, T. A. Silva, and F. Q. Cunha, Dentin-induced in vivo inflammatory response and in vitro activation of murine macrophages, Journal of Dental Research, vol.82, issue.6, pp.460-465, 2003.

C. A. Dinarello, Interleukin-1, Reviews of Infectious Diseases, vol.6, issue.1, pp.51-95, 1984.
URL : https://hal.archives-ouvertes.fr/pasteur-01721887

K. A. Smith, L. B. Lachman, J. J. Oppenheim, and M. F. Favata, The functional relationship of the interleukins, The Journal of Experimental Medicine, vol.151, issue.6, pp.1551-1556, 1980.

T. A. Silva, V. S. Lara, J. S. Silva, G. P. Garlet, W. T. Butler et al., Dentin sialoprotein and phosphoprotein induce neutrophil recruitment: a mechanism dependent on IL-1 , TNF-, and CXC chemokines, Calcified Tissue International, vol.74, issue.6, pp.532-541, 2004.

N. Tani-ishii, C. Wang, and P. Stashenko, Immunolocalization of bone-resorptive cytokines in rat pulp and periapical lesions following surgical pulp exposure, Oral Microbiology and Immunology, vol.10, issue.4, pp.213-219, 1995.

C. Hahn, A. M. Best, and J. G. Tew, Cytokine induction by Streptococcus mutans and pulpal pathogenesis, Infection and Immunity, vol.68, issue.12, pp.6785-6789, 2000.

R. A. Barkhordar, C. Hayashi, and M. Z. Hussain, Detection of interleukin-6 in human dental pulp and periapical lesions, Endodontics and Dental Traumatology, vol.15, issue.1, pp.26-27, 1999.

X. Guo, Z. Niu, M. Xiao, L. Yue, and H. Lu, Detection of interleukin-8 in exudates from normal and inflamed human dental pulp tissues, The Chinese Journal of Dental Research, vol.3, issue.1, pp.63-66, 2000.

E. P. Brennan, X. Tang, A. M. Stewart-akers, L. J. Gudas, and S. F. Badylak, Chemoattractant activity of degradation products of fetal and adult skin extracellular matrix for keratinocyte progenitor cells, Journal of Tissue Engineering and Regenerative Medicine, vol.2, issue.8, pp.491-498, 2008.

J. E. Reing, L. Zhang, and J. Myers-irvin, Degradation products of extracellular matrix affect cell migration and proliferation, Tissue Engineering-Part A, vol.15, issue.3, pp.605-614, 2009.

L. G. Levin, A. Rudd, A. Bletsa, and H. Reisner, Expression of IL-8 by cells of the odontoblast layer in vitro, European Journal of Oral Sciences, vol.107, issue.2, pp.131-137, 1999.

T. A. Silva, V. S. Lara, J. S. Silva, S. H. Oliveira, W. T. Butler et al., Macrophages and mast cells control the neutrophil migration induced by dentin proteins, Journal of Dental Research, vol.84, issue.1, pp.79-83, 2005.

S. Simon, A. J. Smith, A. Berdal, P. J. Lumley, and P. R. Cooper, The MAP kinase pathway is involved in odontoblast stimulation via p38 phosphorylation, Journal of Endodontics, vol.36, issue.2, pp.256-259, 2010.

W. Fiers, R. Beyaert, W. Declercq, and P. Vandenabeele, More than one way to die: apoptosis, necrosis and reactive oxygen damage, Oncogene, vol.18, issue.54, pp.7719-7730, 1999.

M. Guha and N. Mackman, LPS induction of gene expression in human monocytes, Cellular Signalling, vol.13, issue.2, pp.85-94, 2001.

C. Hagemann and J. L. Blank, The ups and downs of MEK kinase interactions, Cellular Signalling, vol.13, issue.12, pp.863-875, 2001.

G. Bergenholtz, Inflammatory response of the dental pulp to bacterial irritation, Journal of Endodontics, vol.7, issue.3, pp.100-104, 1981.

R. B. Rutherford and K. Gu, Treatment of inflamed ferret dental pulps with recombinant bone morphogenetic protein-7, European Journal of Oral Sciences, vol.108, issue.3, pp.202-206, 2000.

K. R. Baumgardner and M. A. Sulfaro, The anti-inflammatory effects of human recombinant copper-zinc superoxide dismutase on pulp inflammation, Journal of Endodontics, vol.27, issue.3, pp.190-195, 2001.

T. Inoue and M. Shimono, Repair dentinogenesis following transplantation into normal and germ-free animals, Proceedings of the Finnish Dental Society, vol.88, pp.183-194, 1992.

A. J. Smith, M. Patel, L. Graham, A. J. Sloan, and P. R. Cooper, Dentin regeneration: key roles for stem cells and molecular signaling, Oral Biosciences & Medicine, vol.2, pp.127-132, 2005.

W. He, Z. Niu, S. Zhao, and A. J. Smith, Smad protein mediated transforming growth factor 1 induction of apoptosis in the MDPC-23 odontoblast-like cell line, Archives of Oral Biology, vol.50, issue.11, pp.929-936, 2005.

M. Pevsner-fischer, V. Morad, and M. Cohen-sfady, Tolllike receptors and their ligands control mesenchymal stem cell functions, Blood, vol.109, issue.4, pp.1422-1432, 2007.

J. Chang, C. Zhang, N. Tani-ishii, S. Shi, and C. Wang, NFkappaB activation in human dental pulp stem cells by TNF and LPS, Journal of Dental Research, vol.84, issue.11, pp.994-998, 2005.

M. Goldberg, J. Farges, and S. Lacerda-pinheiro, Inflammatory and immunological aspects of dental pulp repair, Pharmacological Research, vol.58, issue.2, pp.137-147, 2008.

F. W. Paula-silva, A. Ghosh, L. A. Silva, and Y. L. Kapila, TNF-promotes an odontoblastic phenotype in dental pulp cells, Journal of Dental Research, vol.88, issue.4, pp.339-344, 2009.

W. He, Z. Wang, and Z. Luo, LPS Promote the odontoblastic differentiation of human dental pulp stem cells via MAPK signaling pathway, Journal of Cellular Physiology, vol.230, issue.3, pp.554-561, 2015.

Z. Wang, F. Ma, and J. Wang, Extracellular signal-regulated kinase mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling are required for lipopolysaccharidemediated mineralization in murine odontoblast-like cells, Journal of Endodontics, vol.41, issue.6, pp.871-876, 2015.

Y. Wang, M. Yan, Z. Fan, L. Ma, Y. Yu et al., Mineral trioxide aggregate enhances the odonto/osteogenic capacity of stem cells from inflammatory dental pulps via NF-B pathway, Oral Diseases, vol.20, issue.7, pp.650-658, 2014.

X. Feng, G. Feng, and J. Xing, TNF-triggers osteogenic differentiation of human dental pulp stem cells via the NF-B signalling pathway, Cell Biology International, vol.37, issue.12, pp.1267-1275, 2013.

D. H. Lee, B. Lim, Y. Lee, and H. Yang, Effects of hydrogen peroxide (H 2 O 2 ) on alkaline phosphatase activity and matrix mineralization of odontoblast and osteoblast cell lines, Cell Biology and Toxicology, vol.22, issue.1, pp.39-46, 2006.

K. Saito, M. Nakatomi, H. Ida-yonemochi, S. Kenmotsu, and H. Ohshima, The expression of GM-CSF and osteopontin in immunocompetent cells precedes the odontoblast differentiation following allogenic tooth transplantation in mice, Journal of Histochemistry and Cytochemistry, vol.59, issue.5, pp.518-529, 2011.

A. N. Gurjala, W. R. Liu, J. E. Mogford, P. S. Procaccini, and T. A. Mustoe, Age-dependent response of primary human dermal fibroblasts to oxidative stress: cell survival, pro-survival kinases, and entrance into cellular senescence, Wound Repair and Regeneration, vol.13, issue.6, pp.565-575, 2005.

Y. Lee, G. Kim, and H. Cho, Aging of in vitro pulp illustrates change of inflammation and dentinogenesis, Journal of Endodontics, vol.39, issue.3, pp.340-345, 2013.

C. Murdoch, CXCR4: chemokine receptor extraordinaire, Immunological Reviews, vol.177, pp.175-184, 2000.

R. J. Miller, G. Banisadr, and B. J. Bhattacharyya, CXCR4 signaling in the regulation of stem cell migration and development, Journal of Neuroimmunology, vol.198, issue.1-2, pp.31-38, 2008.

H. Jiang, J. Ling, and Q. Gong, The expression of stromal cell-derived factor 1 (SDF-1) in inflamed human dental pulp, Journal of Endodontics, vol.34, issue.11, pp.1351-1354, 2008.

L. Jiang, Y. Zhu, and R. Du, The expression and role of stromal cell-derived factor-1 -CXCR4 axis in human dental pulp, Journal of Endodontics, vol.34, issue.8, pp.939-944, 2008.

I. About and T. A. Mitsiadis, Molecular aspects of tooth pathogenesis and repair: in vivo and in vitro models, Advances in dental research, vol.15, pp.59-62, 2001.

P. N. Nair, H. F. Duncan, T. R. Pitt-ford, and H. U. Luder, Histological, ultrastructural and quantitative investigations on the response of healthy human pulps to experimental capping with mineral trioxide aggregate: a randomized controlled trial, International Endodontic Journal, vol.41, issue.2, pp.128-150, 2008.

B. W. Hermann, Dentinobliteration der wurzelkanäle nach behandlung mit calcium, Zahnarztl Rundschau, vol.30, pp.887-899, 1930.

U. Schröder, Effects of calcium hydroxide-containing pulpcapping agents on pulp cell migration, proliferation, and differentiation, Journal of Dental Research, vol.64, pp.541-548, 1985.

T. B. Kardos, A. R. Hunter, S. M. Hanlin, and E. E. Kirk, Odontoblast differentiation: a response to environmental calcium, Endodontics and Dental Traumatology, vol.14, issue.3, pp.105-111, 1998.

M. Goldberg, N. Six, and F. Decup, Bioactive molecules and the future of pulp therapy, American Journal of Dentistry, vol.16, issue.1, pp.66-76, 2003.

U. Schröder and L. E. Granath, Early reaction of intact human teeth to calcium hydroxide following experimental pulpotomy and its significance to the development of hard tissue barrier, Odontologisk Revy, vol.22, issue.4, pp.379-395, 1971.

H. Stanley, Calcium hydroxide and vital pulp therapy, pp.309-324, 2002.

L. Graham, P. R. Cooper, N. Cassidy, J. E. Nor, A. J. Sloan et al., The effect of calcium hydroxide on solubilisation of bio-active dentine matrix components, Biomaterials, vol.27, issue.14, pp.2865-2873, 2006.

P. L. Tomson, L. M. Grover, P. J. Lumley, A. J. Sloan, A. J. Smith et al., Dissolution of bio-active dentine matrix components by mineral trioxide aggregate, Journal of Dentistry, vol.35, issue.8, pp.636-642, 2007.

F. Brentano, O. Schorr, R. E. Gay, S. Gay, and D. Kyburz, RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3, Arthritis and Rheumatism, vol.52, issue.9, pp.2656-2665, 2005.

N. M. Luheshi, B. W. Mccoll, and D. Brough, Nuclear retention of IL-1 by necrotic cells: a mechanism to dampen sterile inflammation, European Journal of Immunology, vol.39, issue.11, pp.2973-2980, 2009.

G. Acosta-pérez, M. Maximina-bertha-moreno-altamirano, G. Rodríguez-luna, and F. J. Sánchez-garcia, Differential dependence of the ingestion of necrotic cells and TNF-alpha/IL1beta production by murine macrophages on lipid rafts, Scandinavian Journal of Immunology, vol.68, issue.4, pp.423-429, 2008.

I. F. Magalhães-santos and S. G. Andrade, Participation of cytokines in the necrotic-inflammatory lesions in the heart and skeletal muscles of Calomys callosus infected with Trypanosoma cruzi, Memórias do Instituto Oswaldo Cruz, vol.100, pp.555-561, 2005.

T. R. Ford, M. Torabinejad, H. R. Abedi, L. K. Bakland, and S. P. Kariyawasam, Using mineral trioxide aggregate: as a pulpcapping material, Journal of the American Dental Association, vol.127, issue.10, pp.1491-1494, 1996.

I. M. Faraco and R. Holland, Response of the pulp of dogs to capping with mineral trioxide aggregate or a calcium hydroxide cement, Dental Traumatology, vol.17, issue.4, pp.163-166, 2001.

M. Aeinehchi, S. Dadvand, S. Fayazi, and S. Bayat-movahed, Randomized controlled trial of mineral trioxide aggregate and formocresol for pulpotomy in primary molar teeth, International Endodontic Journal, vol.40, issue.4, pp.261-267, 2007.

U. Schröder and B. Sundström, Transmission electron microscopy of tissue changes following experimental pulpotomy of intact human teeth and capping with calcium hydroxide, Odontologisk Revy, vol.25, issue.1, pp.57-68, 1974.

T. H. Huang, C. C. Yang, S. J. Ding, M. Yeng, C. T. Kao et al., Inflammatory cytokines reaction elicited by root-end filling materials, Journal of Biomedical Materials ResearchPart B: Applied Biomaterials, vol.73, issue.1, pp.123-128, 2005.

P. J. Mitchell, T. R. Pitt-ford, M. Torabinejad, and F. Mcdonald, Osteoblast biocompatibility of mineral trioxide aggregate, Biomaterials, vol.20, issue.2, pp.167-173, 1999.

E. T. Koh, F. Mcdonald, T. R. Pitt-ford, and M. Torabinejad, Cellular response to mineral trioxide aggregate, Journal of Endodontics, vol.24, issue.8, pp.543-547, 1998.

E. Zudaire, S. Portal-núñez, and F. Cuttitta, The central role of adrenomedullin in host defense, Journal of Leukocyte Biology, vol.80, issue.2, pp.237-244, 2006.

L. M. Montuenga, A. Martíez, M. J. Miller, E. J. Unsworth, and F. Cuttitta, Expression of adrenomedullin and its receptor during embryogenesis suggests autocrine or paracrine modes of action, Endocrinology, vol.138, issue.1, pp.440-451, 1997.

M. Ishii, C. Koike, and A. Igarashi, Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts, Biochemical and Biophysical Research Communications, vol.332, issue.1, pp.297-303, 2005.

J. Cornish, K. E. Callon, and D. H. Coy, Adrenomedullin is a potent stimulator of osteoblastic activity in vitro and in vivo, American Journal of Physiology, vol.273, issue.6, pp.1113-1120, 1997.

D. S. Musson, J. L. Mclachlan, A. J. Sloan, A. J. Smith, and P. R. Cooper, Adrenomedullin is expressed during rodent dental tissue development and promotes cell growth and mineralization, Biology of the Cell, vol.102, issue.3, pp.145-157, 2010.

M. P. De-miguel, S. Fuentes-julián, and A. Blázquez-martínez, Immunosuppressive properties of mesenchymal stem cells: advances and applications, Current Molecular Medicine, vol.12, issue.5, pp.574-591, 2012.

J. G. Leprince, B. D. Zeitlin, M. Tolar, and O. A. Peters, Interactions between immune system and mesenchymal stem cells in dental pulp and periapical tissues, International Endodontic Journal, vol.45, issue.8, pp.689-701, 2012.

S. Tomic, J. Djokic, and S. Vasilijic, Immunomodulatory properties of mesenchymal stem cells derived from dental pulp and dental follicle are susceptible to activation by toll-like receptor agonists, Stem Cells and Development, vol.20, issue.4, pp.695-708, 2011.

L. C. Henriques, L. C. De-brito, W. L. Tavares, L. Q. Vieira, and A. P. Sobrinho, Cytokine analysis in lesions refractory to endodontic treatment, Journal of Endodontics, vol.37, issue.12, pp.1659-1662, 2011.

M. Yamada, N. Kojima, and A. Paranjpe, N-acetyl cysteine (NAC)-assisted detoxification of PMMA resin, Journal of Dental Research, vol.87, issue.4, pp.372-377, 2008.

J. Kim, Y. Lee, and M. Yu, Anti-inflammatory mechanism of PPAR on LPS-induced pulp cells: role of the ROS removal activity, Archives of Oral Biology, vol.57, issue.4, pp.392-400, 2012.

Y. Lee, N. Lee, and G. Bhattarai, Anti-inflammatory effect of pachymic acid promotes odontoblastic differentiation via HO-1 in dental pulp cells, Oral Diseases, vol.19, issue.2, pp.193-199, 2013.

S. Zhong, S. Zhang, E. Bair, S. Nares, and A. A. Khan, Differential expression of microRNAs in normal and inflamed human pulps, Journal of Endodontics, vol.38, issue.6, pp.746-752, 2012.