Dental Pulp Defence and Repair Mechanisms in Dental Caries

Jean-Christophe Farges 1, 2, 3, * Brigitte Alliot-Licht 4 Emmanuelle Renard 4 Maxime Ducret 1, 2, 3 Alexis Gaudin 4 Anthony Smith 5 Paul Cooper 5
* Corresponding author
1 LBTI - Laboratoire de Biologie Tissulaire et d'ingénierie Thérapeutique UMR 5305
2 UFR d’Odontologie, Université de Lyon,
3 Service de Consultations et de Traitements Dentaires [HCL, Lyon]
4 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie
5 School of Dentistry - Oral Biology [Birmingham, UK]
Abstract : Dental caries is a chronic infectious disease resulting from the penetration of oral bacteria into the enamel and dentin. Microorganisms subsequently trigger inflammatory responses in the dental pulp. These events can lead to pulp healing if the infection is not too severe following the removal of diseased enamel and dentin tissues and clinical restoration of the tooth. However, chronic inflammation often persists in the pulp despite treatment, inducing permanent loss of normal tissue and reducing innate repair capacities. For complete tooth healing the formation of a reactionary/reparative dentin barrier to distance and protect the pulp from infectious agents and restorative materials is required. Clinical and in vitro experimental data clearly indicate that dentin barrier formation only occurs when pulp inflammation and infection are minimised, thus enabling reestablishment of tissue homeostasis and health. Therefore, promoting the resolution of pulp inflammation may provide a valuable therapeutic opportunity to ensure the sustainability of dental treatments. This paper focusses on key cellular and molecular mechanisms involved in pulp responses to bacteria and in the pulpal transition between caries-induced inflammation and dentinogenic-based repair. We report, using selected examples, different strategies potentially used by odontoblasts and specialized immune cells to combat dentin-invading bacteria in vivo.
Document type :
Journal articles
Complete list of metadatas

Cited literature [169 references]  Display  Hide  Download
https://www.hal.inserm.fr/inserm-02146799
Contributor : Ana Paula Dutra Azevedo <>
Submitted on : Tuesday, June 4, 2019 - 11:30:10 AM
Last modification on : Thursday, November 21, 2019 - 2:21:10 AM

File

2015DentalMI2015-230251.pdf
Publisher files allowed on an open archive

Identifiers

Collections

HCL | CNRS | UNIV-LYON1 | UNIV-NANTES | CRTI | UDL

Citation

Jean-Christophe Farges, Brigitte Alliot-Licht, Emmanuelle Renard, Maxime Ducret, Alexis Gaudin, et al.. Dental Pulp Defence and Repair Mechanisms in Dental Caries. Mediators of Inflammation, Hindawi Publishing Corporation, 2015, 2015, pp.1-16. ⟨10.1155/2015/230251⟩. ⟨inserm-02146799⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

55

Files downloads

98

Contact

Informations

CCSD