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Kalergis AM: Central nervous system alterations caused by infection with the human respiratory syncytial virus, Rev Med Virol, vol.24, pp.407-419, 2014. ,
, In this review is discussed recent findings linking the neurological, extrapulmonary effects of hRSV with infection and functional impairment of the CNS
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Alpha/beta interferon receptor signaling amplifies early proinflammatory cytokine production in the lung during respiratory syncytial virus infection, J Virol, vol.88, pp.6128-6136, 2014. ,
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Attenuation of respiratory syncytial virus-induced and rig-i-dependent type i ifn responses in human neonates and very young children, J Immunol, vol.192, pp.948-957, 2014. ,
Defective innate immune responses to respiratory syncytial virus infection in ovalbumin-sensitized mice, J Microbiol Immunol Infect, 2014. ,
Interferon lambda 1-3 expression in infants hospitalized for rsv or hrv associated bronchiolitis, J Infect, vol.68, pp.467-477, 2014. ,
, The authors present evidence of differences in the IFN lambda 1-3 levels in infants hospitalized for respiratory syncytial virus (RSV) or rhinovirus (HRV) bronchiolitis
Ifn-lambda (ifn-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo, PLoS Pathog, vol.4, p.1000017, 2008. ,
Tlr2/myd88/nfkappab pathway, reactive oxygen species, potassium efflux activates nlrp3/asc inflammasome during respiratory syncytial virus infection, PLoS One, vol.7, p.29695, 2012. ,
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URL : https://hal.archives-ouvertes.fr/inserm-02162213
Il-27r-mediated regulation of il-17 controls the development of respiratory syncytial virus-associated pathogenesis, Am J Pathol, vol.184, pp.1807-1818, 2014. ,
A novel respiratory syncytial virus (RSV) f subunit vaccine adjuvanted with gla-se elicits robust protective th1-type humoral and cellular immunity in rodent models, PLoS One, vol.10, p.119509, 2015. ,
Severe respiratory syncytial virus infections and reduced interferon-gamma generation in vitro, Clin Exp Immunol, vol.138, pp.102-109, 2004. ,
Specific increase in local il-17 production during recovery from primary rsv bronchiolitis, J Med Virol, vol.84, pp.1084-1088, 2012. ,
Structure and signalling in the il-17 receptor family, Nat Rev Immunol, vol.9, pp.556-567, 2009. ,
Elevated th17 response in infants undergoing respiratory viral infection, Am J Pathol, vol.184, pp.1274-1279, 2014. ,
, The authors show that Th17 cells are absent in healthy newborns, Th17 cells are present in peripheral blood and the airways of infants that experience viral infection
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Mechanisms of respiratory syncytial virus modulation of airway immune responses, Curr Allergy Asthma Rep, vol.12, pp.380-387, 2012. ,
Respiratory syncytial virus synergizes with th2 cytokines to induce optimal levels of tarc/ccl17, J Immunol, vol.179, pp.1648-1658, 2007. ,
Respiratory syncytial virus infection and recurrent wheezing in Chilean infants: a genetic background, Infect Genet Evol, vol.16, pp.54-61, 2013. ,
, This study shows that IL-4/IL-13 pathway is involved in RSV infection conditions. Authors evaluated by a candidate-gene approach, whether genetic polymorphisms in IL-4/IL-13 pathway are associated with RSV infection severity and its outcome in Chilean children
Il-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease, J Immunol, vol.180, pp.2376-2384, 2008. ,
Association between severe respiratory syncytial virus infection and il13/il4 haplotypes, J Infect Dis, vol.193, pp.438-441, 2006. ,
Production of chemokines in respiratory syncytial virus infection with central nervous system manifestations, J Infect Chemother, vol.18, pp.827-831, 2012. ,
, this study the roles of cytokines in the CSF was evaluated suggest that chemokines in CSF play roles in neurological complications in RSVinfected children
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