Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases - Archive ouverte HAL Access content directly
Journal Articles Autoimmunity Reviews Year : 2015

Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases

(1) , (2) , (2) , (3) , (4, 5) , (4, 1) , (4, 1, 2)
1
2
3
4
5

Abstract

Dendritic cells (DCs) play a key role in the activation of the immune response against pathogens, as well as in the modulation of peripheral tolerance to self-antigens (Ags). Furthermore, an imbalance in the activating/inhibitory receptors expressed on the surface of DCs has been linked to increased susceptibility to develop autoimmune diseases underscoring their immunogenicity potential. It has been described that modulation of activating or inhib-itory molecules expressed by DCs, such as CD86, TLRs, PDL-1 and FcγRs, can define the immunogenic phenotype. On the other hand, T cell tolerance can be achieved by tolerogenic DCs, which have the capacity of blocking un-desired autoimmune responses in several experimental models, mainly by inducing T cell anergy, expansion of regulatory T cells and limiting B cell responses. Due to the lack of specific therapies to treat autoimmune disorders and the tolerogenic capacity of DCs shown in experimental autoimmune disease models, autologous tolDCs are a potential therapeutic strategy for fine-tuning the immune system and reestablishing tolerance in human autoim-mune diseases. New advances in the role of DCs in systemic lupus erythematosus (SLE) pathogenesis and the identification of pathogenic self-Ags may favor the development of novel tolDC based therapies with a major clinical impact. In this review, we discuss recent data relative to the role of DCs in systemic autoimmune pathogen-esis and their use as a therapy to restore tolerance.
Embargoed file
Embargoed file
Ne sera jamais visible
Loading...

Dates and versions

inserm-02146510 , version 1 (04-06-2019)

Identifiers

Cite

Juan Pablo Mackern-Oberti, Carolina Llanos, Fabián Vega, Flavio Salazar-Onfray, Claudia A Riedel, et al.. Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases. Autoimmunity Reviews, 2015, 14 (2), pp.127-139. ⟨10.1016/j.autrev.2014.10.010⟩. ⟨inserm-02146510⟩
62 View
1 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More