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Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

Michelle Daya Nicholas Rafaels Tonya Brunetti Sameer Chavan Albert Levin Aniket Shetty Christopher Gignoux Meher Preethi Boorgula Genevieve Wojcik Monica Campbell Candelaria Vergara Dara Torgerson Victor Ortega Ayo Doumatey Henry Richard Johnston Nathalie Acevedo Maria Ilma Araujo Pedro Avila Gillian Belbin Eugene Bleecker Carlos Bustamante Luis Caraballo Alvaro Cruz Georgia Dunston Celeste Eng Mezbah Faruque Trevor Ferguson Camila Figueiredo Jean Ford Weiniu Gan Pierre-Antoine Gourraud 1 Nadia Hansel Ryan Hernandez Edwin Francisco Herrera-Paz Silvia Jimenez Eimear Kenny Jennifer Knight-Madden Rajesh Kumar Leslie Lange Ethan Lange Antoine Lizee 2 Pissamai Maul Trevor Maul Alvaro Mayorga Deborah Meyers Dan Nicolae Timothy O’connor Ricardo Riccio Oliveira Christopher Olopade Olufunmilayo Olopade Zhaohui Qin Charles Rotimi Nicolas Vince 1 Harold Watson Rainford Wilks James Wilson Steven Salzberg Carole Ober Esteban Burchard L. Keoki Williams Terri Beaty Margaret Taub Ingo Ruczinski Rasika Mathias Kathleen Barnes
1 Team 5 - U1064 Inserm - CRTI - Translational ImmunoGenetic in AutoImmunity and Transplantation
U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie
2 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie
Abstract : Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genomewide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12–q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.
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Submitted on : Monday, June 3, 2019 - 3:21:49 PM
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Michelle Daya, Nicholas Rafaels, Tonya Brunetti, Sameer Chavan, Albert Levin, et al.. Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations. Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-08469-7⟩. ⟨inserm-02146016⟩

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