F. Sallusto, A. Lanzavecchia, K. Araki, and R. Ahmed, From vaccines to memory and back, Immunity, vol.33, pp.451-463, 2010.
DOI : 10.1016/j.immuni.2010.10.008

URL : https://doi.org/10.1016/j.immuni.2010.10.008

K. G. Smith, A. Light, G. J. Nossal, and D. M. Tarlinton, The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response, EMBO J, vol.16, pp.2996-3006, 1997.

T. G. Phan, D. Paus, T. D. Chan, M. L. Turner, S. L. Nutt et al., High affinity germinal center B cells are actively selected into the plasma cell compartment, J. Exp. Med, vol.203, pp.2419-2424, 2006.

J. M. Porto, A. M. Haberman, G. Kelsoe, and M. J. Shlomchik, Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced, J. Exp. Med, vol.195, pp.1215-1221, 2002.

Y. Fu, Z. Zhang, J. Sheehan, Y. Avnir, C. Ridenour et al., A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutininspecific memory B cells to evolve, Nat. Commun, vol.7, p.12780, 2016.

G. M. Li, C. Chiu, J. Wrammert, M. Mccausland, S. F. Andrews et al., Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells, Proc. Natl. Acad. Sci. U.S.A, vol.109, pp.9047-9052, 2012.

W. E. Purtha, T. F. Tedder, S. Johnson, D. Bhattacharya, and M. S. Diamond, Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants, J. Exp. Med, vol.208, pp.2599-2606, 2011.

N. Baumgarth, How specific is too specific? B-cell responses to viral infections reveal the importance of breadth over depth, Immunol. Rev, vol.255, pp.82-94, 2013.

S. G. Tangye, D. T. Avery, E. K. Deenick, and P. D. Hodgkin, Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses, J. Immunol, vol.170, pp.686-694, 2003.

M. J. Mamula, Epitope spreading: the role of self peptides and autoantigen processing by B lymphocytes, Immunol. Rev, vol.164, pp.231-239, 1998.

H. Noorchashm, Y. K. Lieu, N. Noorchashm, S. Y. Rostami, S. A. Greeley et al., I-A(g7)-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic mice, J. Immunol, vol.163, pp.743-750, 1999.

A. Inamine, Y. Takahashi, N. Baba, K. Miyake, T. Tokuhisa et al., Two waves of memory B-cell generation in the primary immune response, Int. Immunol, vol.17, pp.581-589, 2005.

G. D. Victora and M. C. Nussenzweig, Germinal centers, Annu. Rev. Immunol, vol.30, pp.429-457, 2012.

C. D. Allen, T. Okada, and J. G. Cyster, Germinal-center organization and cellular dynamics, vol.27, pp.190-202, 2007.

J. Jacob, R. Kassir, and G. Kelsoe, In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations, J. Exp. Med, vol.173, pp.1165-1175, 1991.

Y. J. Liu, J. Zhang, P. J. Lane, E. Y. Chan, and I. C. Maclennan, Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens, Eur. J. Immunol, vol.21, pp.2951-2962, 1991.

C. C. Goodnow, C. G. Vinuesa, K. L. Randall, F. Mackay, and R. Brink, Control systems and decision making for antibody production, Nat. Immunol, vol.11, pp.681-688, 2010.

T. Inoue, I. Moran, R. Shinnakasu, T. G. Phan, and T. Kurosaki, Generation of memory B cells and their reactivation, Immunol. Rev, vol.283, pp.138-149, 2018.

D. Paus, T. G. Phan, T. D. Chan, S. Gardam, A. Basten et al., Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation, J. Exp. Med, vol.203, pp.1081-1091, 2006.

B. P. O'connor, L. A. Vogel, W. Zhang, W. Loo, D. Shnider et al., Imprinting the fate of antigen-reactive B cells through the affinity of the B cell receptor, J. Immunol, vol.177, pp.7723-7732, 2006.

T. D. Chan, D. Gatto, K. Wood, T. Camidge, A. Basten et al., Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts, J. Immunol, vol.183, pp.3139-3149, 2009.

T. G. Phan, S. Gardam, A. Basten, and R. Brink, Altered migration, recruitment, and somatic hypermutation in the early response of marginal zone B cells to T celldependent antigen, J. Immunol, vol.174, pp.4567-4578, 2005.

T. A. Schwickert, G. D. Victora, D. R. Fooksman, A. O. Kamphorst, M. R. Mugnier et al., A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center, J. Exp. Med, vol.208, pp.1243-1252, 2011.

D. Gatto, T. Pfister, A. Jegerlehner, S. W. Martin, M. Kopf et al., Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1, J. Exp. Med, vol.201, pp.993-1005, 2005.

A. Bolduc, E. Long, D. Stapler, M. Cascalho, T. Tsubata et al., Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas, J. Immunol, vol.185, pp.220-230, 2010.

S. L. Nutt, P. D. Hodgkin, D. M. Tarlinton, and L. M. Corcoran, The generation of antibodysecreting plasma cells, Nat. Rev. Immunol, vol.15, pp.160-171, 2015.

K. Ozaki, R. Spolski, R. Ettinger, H. P. Kim, G. Wang et al., Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6, J. Immunol, vol.173, pp.5361-5371, 2004.

L. Moens and S. G. Tangye, Cytokine-mediated regulation of plasma cell generation: IL-21 takes center stage, Front. Immunol, vol.5, p.65, 2014.

G. Maarof, L. Bouchet-delbos, H. Gary-gouy, I. Durand-gasselin, R. Krzysiek et al., Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells, Blood, vol.115, pp.1718-1726, 2010.

T. Recaldin and D. J. Fear, Transcription factors regulating B cell fate in the germinal centre, Clin. Exp. Immunol, vol.183, pp.65-75, 2016.

J. Hasbold, L. M. Corcoran, D. M. Tarlinton, S. G. Tangye, and P. D. Hodgkin, Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation, Nat. Immunol, vol.5, pp.55-63, 2004.

P. D. Hodgkin, J. H. Lee, and A. B. Lyons, B cell differentiation and isotype switching is related to division cycle number, J. Exp. Med, vol.184, pp.277-281, 1996.

S. Crotty, R. J. Johnston, and S. P. Schoenberger, Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation, Nat. Immunol, vol.11, pp.114-120, 2010.

U. Klein and R. Dalla-favera, Germinal centres: role in B-cell physiology and malignancy, Nat. Rev. Immunol, vol.8, pp.22-33, 2008.

R. I. Nurieva, Y. Chung, G. J. Martinez, X. O. Yang, S. Tanaka et al., Bcl6 mediates the development of T follicular helper cells, Science, vol.325, pp.1001-1005, 2009.

Y. K. Chiu, I. Y. Lin, S. T. Su, K. H. Wang, S. Y. Yang et al., Transcription factor ABF-1 suppresses plasma cell differentiation but facilitates memory B cell formation, J. Immunol, vol.193, pp.2207-2217, 2014.

R. Shinnakasu, T. Inoue, K. Kometani, S. Moriyama, Y. Adachi et al., Regulated selection of germinal-center cells into the memory B cell compartment, Nat. Immunol, vol.17, pp.861-869, 2016.

M. Gstaiger, L. Knoepfel, O. Georgiev, W. Schaffner, and C. M. Hovens, A B-cell coactivator of octamer-binding transcription factors, Nature, vol.373, pp.360-362, 1995.

U. Kim, X. F. Qin, S. Gong, S. Stevens, Y. Luo et al., The B-cellspecific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes, Nature, vol.383, pp.542-547, 1996.

P. J. Nielsen, O. Georgiev, B. Lorenz, and W. Schaffner, B lymphocytes are impaired in mice lacking the transcriptional co-activator Bob1/OCA-B/OBF1, Eur. J. Immunol, vol.26, pp.3214-3218, 1996.

D. B. Schubart, A. Rolink, M. H. Kosco-vilbois, F. Botteri, and P. Matthias, B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation, Nature, vol.383, pp.538-542, 1996.

M. J. Levels, M. N. Van-tok, T. Cantaert, J. D. Canete, F. G. Kroese et al., The transcriptional coactivator Bob1 is associated with pathologic B cell responses in autoimmune tissue inflammation, Arthritis Rheum, vol.69, pp.750-762, 2017.

D. Aletaha, T. Neogi, A. J. Silman, J. Funovits, D. T. Felson et al., Rheumatoid arthritis classification criteria: an American College of Rheumatology/ European League against Rheumatism collaborative initiative, Ann. Rheum. Dis, vol.69, pp.1580-1588, 2010.
URL : https://hal.archives-ouvertes.fr/hal-01557559

M. J. De-hair, I. A. Zijlstra, M. J. Boumans, M. G. Van-de-sande, M. Maas et al., Hunting for the pathogenesis of rheumatoid arthritis: core-needle biopsy of inguinal lymph nodes as a new research tool, Ann. Rheum. Dis, vol.71, pp.1911-1912, 2012.

L. G. Van-baarsen, M. J. De-hair, T. H. Ramwadhdoebe, I. J. Zijlstra, M. Maas et al., The cellular composition of lymph nodes in the earliest phase of inflammatory arthritis, Ann. Rheum. Dis, vol.72, pp.1420-1424, 2013.

M. J. Kwakkenbos, S. A. Diehl, E. Yasuda, A. Q. Bakker, C. M. Van-geelen et al., Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming, Nat. Med, vol.16, pp.123-128, 2010.

M. J. Kwakkenbos, A. Q. Bakker, P. M. Van-helden, K. Wagner, E. Yasuda et al., Genetic manipulation of B cells for the isolation of rare therapeutic antibodies from the human repertoire, Methods, vol.65, pp.38-43, 2014.

E. Bettelli, M. Pagany, H. L. Weiner, C. Linington, R. A. Sobel et al., Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis, J. Exp. Med, vol.197, pp.1073-1081, 2003.

X. Yu, L. Wang, Y. Luo, and R. G. Roeder, Identification and characterization of a novel OCA-B isoform. implications for a role in B cell signaling pathways, Immunity, vol.14, pp.157-167, 2001.

V. Peperzak, I. Vikstrom, J. Walker, S. P. Glaser, M. Lepage et al., Mcl-1 is essential for the survival of plasma cells, Nat. Immunol, vol.14, pp.290-297, 2013.

R. Ettinger, G. P. Sims, A. M. Fairhurst, R. Robbins, Y. S. Silva et al., IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells, J. Immunol, vol.175, pp.7867-7879, 2005.

S. Kuchen, R. Robbins, G. P. Sims, C. Sheng, T. M. Phillips et al., Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration, J. Immunol, vol.179, pp.5886-5896, 2007.

M. Jourdan, A. Caraux, J. De, G. Vos, M. Fiol et al., An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization, Blood, vol.114, pp.5173-5181, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00446133

A. Greiner, K. B. Muller, J. Hess, K. Pfeffer, H. K. Muller-hermelink et al., Upregulation of BOB.1/OBF.1 expression in normal germinal center B cells and germinal center-derived lymphomas, Am. J. Pathol, vol.156, pp.501-507, 2000.

T. Onizuka, M. Moriyama, T. Yamochi, T. Kuroda, A. Kazama et al., BCL-6 gene product, a 92-to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts, Blood, vol.86, pp.28-37, 1995.

F. A. Scheeren, M. Naspetti, S. Diehl, R. Schotte, M. Nagasawa et al., STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression, Nat. Immunol, vol.6, pp.303-313, 2005.

S. A. Diehl, H. Schmidlin, M. Nagasawa, S. D. Van-haren, M. J. Kwakkenbos et al., STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation, J. Immunol, vol.180, pp.4805-4815, 2008.

M. Perez-andres, B. Paiva, W. G. Nieto, A. Caraux, A. Schmitz et al., Human peripheral blood B-cell compartments: a crossroad in B-cell traffic, Cytomet. B Clin. Cytom, vol.78, issue.1, pp.47-60, 2010.

T. C. Kuo, A. L. Shaffer, J. Haddad, Y. S. Choi, L. M. Staudt et al., Repression of BCL-6 is required for the formation of human memory B cells in vitro, J. Exp. Med, vol.204, pp.819-830, 2007.

S. G. Tangye and D. M. Tarlinton, Memory B cells: effectors of long-lived immune responses, Eur. J. Immunol, vol.39, pp.2065-2075, 2009.

A. Shimabukuro-vornhagen, E. Kondo, T. Liebig, and M. Bergwelt-baildon, Activated human B cells: stimulatory or tolerogenic antigen-presenting cells?, Blood, vol.114, pp.746-747, 2009.

S. Amu, A. Tarkowski, T. Dorner, M. Bokarewa, and M. Brisslert, The human immunomodulatory CD25+ B cell population belongs to the memory B cell pool, Scand. J. Immunol, vol.66, pp.77-86, 2007.

J. J. Taylor, K. A. Pape, H. R. Steach, and M. K. Jenkins, Apoptosis and antigen affinity limit effector cell differentiation of a single naive B cell, Humoral immunity, vol.347, pp.784-787, 2015.

P. Hou, E. Araujo, T. Zhao, M. Zhang, D. Massenburg et al., B cell antigen receptor signaling and internalization are mutually exclusive events, PLoS Biol, issue.4, p.200, 2006.
DOI : 10.1371/journal.pbio.0040200

URL : https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0040200&type=printable

R. Glynne, G. Ghandour, J. Rayner, D. H. Mack, and C. C. Goodnow, B-lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays, Immunol. Rev, vol.176, pp.216-246, 2000.

R. Krzysiek, E. A. Lefevre, W. Zou, A. Foussat, J. Bernard et al., Antigen receptor engagement selectively induces macrophage inflammatory protein-1 alpha (MIP-1 alpha) and MIP-1 beta chemokine production in human B cells, J. Immunol, vol.162, pp.4455-4463, 1999.

X. F. Qin, A. Reichlin, Y. Luo, R. G. Roeder, and M. C. Nussenzweig, OCA-B integrates B cell antigen receptor-, CD40L-and IL 4-mediated signals for the germinal center pathway of B cell development, EMBO J, vol.17, pp.5066-5075, 1998.

X. Ren, R. Siegel, U. Kim, and R. G. Roeder, Direct interactions of OCA-B and TFII-I regulate immunoglobulin heavy-chain gene transcription by facilitating enhancerpromoter communication, Mol. Cell, vol.42, pp.342-355, 2011.

R. Casellas, M. Jankovic, G. Meyer, A. Gazumyan, Y. Luo et al., OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes, Cell, vol.110, pp.575-585, 2002.

M. Jankovic and M. C. Nussenzweig, OcaB regulates transitional B cell selection, Int. Immunol, vol.15, pp.1099-1104, 2003.
DOI : 10.1093/intimm/dxg109

URL : https://academic.oup.com/intimm/article-pdf/15/9/1099/2228091/dxg109.pdf

J. Hess, P. J. Nielsen, K. D. Fischer, H. Bujard, and T. Wirth, The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B-cell development, Mol. Cell Biol, vol.21, pp.1531-1539, 2001.

A. Karnowski, C. Cao, G. Matthias, S. Carotta, L. M. Corcoran et al., Silencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1, PLoS One, vol.3, p.3568, 2008.

J. Sun, G. Matthias, M. J. Mihatsch, K. Georgopoulos, and P. Matthias, Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice, J. Immunol, vol.170, pp.1699-1706, 2003.

T. Samardzic, D. Marinkovic, P. J. Nielsen, L. Nitschke, and T. Wirth, BOB.1/OBF.1 deficiency affects marginal-zone B-cell compartment, Mol. Cell Biol, vol.22, pp.8320-8331, 2002.

L. M. Corcoran, J. Hasbold, W. Dietrich, E. Hawkins, A. Kallies et al., Differential requirement for OBF-1 during antibody-secreting cell differentiation, J. Exp. Med, vol.201, pp.1385-1396, 2005.

F. Benaglio, B. Vitolo, M. Scarabelli, E. Binda, S. Bugatti et al., The draining lymph node in rheumatoid arthritis: current concepts and research perspectives, BioMed Res. Int, p.420251, 2015.

K. Ochiai, M. Maienschein-cline, G. Simonetti, J. Chen, R. Rosenthal et al., Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4, Immunity, vol.38, pp.918-929, 2013.

B. B. Ding, E. Bi, H. Chen, J. J. Yu, and B. H. Ye, IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells, J. Immunol, vol.190, pp.1827-1836, 2013.

T. Nojima, K. Haniuda, T. Moutai, M. Matsudaira, S. Mizokawa et al., In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo, Nat. Commun, vol.2, p.465, 2011.

N. S. Silva and U. Klein, Dynamics of B cells in germinal centres, Nat. Rev. Immunol, vol.15, pp.137-148, 2015.

S. M. Anderson, M. M. Tomayko, A. Ahuja, A. M. Haberman, and M. J. Shlomchik, New markers for murine memory B cells that define mutated and unmutated subsets, J. Exp. Med, vol.204, pp.2103-2114, 2007.

A. Bar-or, E. M. Oliveira, D. E. Anderson, J. I. Krieger, M. Duddy et al., Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state, J. Immunol, vol.167, pp.5669-5677, 2001.

K. L. Good, D. T. Avery, and S. G. Tangye, Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naive B cells, J. Immunol, vol.182, pp.890-901, 2009.

C. Van-kooten and J. Banchereau, CD40-CD40 ligand, J. Leukoc. Biol, vol.67, pp.2-17, 2000.

G. V. Zuccarino-catania, S. Sadanand, F. J. Weisel, M. M. Tomayko, H. Meng et al., CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype, Nat. Immunol, vol.15, pp.631-637, 2014.

U. Klein, Y. Tu, G. A. Stolovitzky, J. L. Keller, J. Haddad et al., Gene expression dynamics during germinal center transit in B cells, Ann. N. Y. Acad. Sci, vol.987, pp.166-172, 2003.

F. Lechouane, A. Bonaud, L. Delpy, S. Casola, Z. Oruc et al., B-cell receptor signal strength influences terminal differentiation, Eur. J. Immunol, vol.43, pp.619-628, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00779414

S. Casola, K. L. Otipoby, M. Alimzhanov, S. Humme, N. Uyttersprot et al., B cell receptor signal strength determines B cell fate, Nat. Immunol, vol.5, pp.317-327, 2004.

P. Tong, A. Granato, T. Zuo, N. Chaudhary, A. Zuiani et al., IgH isotypespecific B cell receptor expression influences B cell fate, Proc. Natl. Acad. Sci. U. S. A, vol.114, pp.8411-8420, 2017.

Y. Zhou, X. Liu, L. Xu, Z. R. Hunter, Y. Cao et al., Transcriptional repression of plasma cell differentiation is orchestrated by aberrant over-expression of the ETS factor SPIB in Waldenstrom macroglobulinaemia, Br. J. Haematol, vol.166, pp.677-689, 2014.

M. Kilzheimer, J. Quandt, J. Langhans, P. Weihrich, T. Wirth et al., NFkappaB-dependent signals control BOB.1/OBF.1 and Oct2 transcriptional activity in B cells, Eur. J. Immunol, vol.45, pp.3441-3453, 2015.

B. Bartholdy, C. Du-roure, A. Bordon, D. Emslie, L. M. Corcoran et al., The Ets factor Spi-B is a direct critical target of the coactivator OBF-1, Proc. Natl. Acad. Sci. U. S. A, vol.103, pp.11665-11670, 2006.

K. Basso and R. Dalla-favera, BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis, Adv. Immunol, vol.105, pp.193-210, 2010.