Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries, Clin Microbiol Infect, vol.24, pp.1158-63, 2018. ,
Community-acquired pneumonia requiring hospitalization among U.S. adults, N Engl J Med, vol.373, pp.415-442, 2015. ,
Dynamics of lung defense in pneumonia: resistance, resilience, and remodeling, Annu Rev Physiol, vol.77, pp.407-437, 2015. ,
Overcoming the current deadlock in antibiotic research, Trends Microbiol, vol.22, pp.165-172, 2014. ,
Action Plan on Antimicrobial Resistance ,
Targeting toll-like receptors: promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases, Front Immunol, vol.4, p.387, 2013. ,
Modulating immunity as a therapy for bacterial infections, Nat Rev Microbiol, vol.10, pp.243-54, 2012. ,
DOI : 10.1038/nrmicro2745
Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection, J Infect Dis, vol.201, pp.534-577, 2010. ,
DOI : 10.1086/650203
URL : https://academic.oup.com/jid/article-pdf/201/4/534/18060407/201-4-534.pdf
Vancomycinresistant enterococci exploit antibiotic-induced innate immune deficits, Nature, vol.455, pp.804-811, 2008. ,
DOI : 10.1038/nature07250
URL : http://europepmc.org/articles/pmc2663337?pdf=render
TLR-7 activation enhances IL-22-mediated colonization resistance against vancomycin-resistant enterococcus, Sci Transl Med, vol.8, pp.327-352, 2016. ,
DOI : 10.1126/scitranslmed.aad6663
URL : https://stm.sciencemag.org/content/scitransmed/8/327/327ra25.full.pdf
Compartmentalized antimicrobial defenses in response to flagellin, Trends Microbiol, vol.26, pp.423-458, 2018. ,
DOI : 10.1016/j.tim.2017.10.008
URL : https://hal.archives-ouvertes.fr/inserm-01671191
Flagellin treatment protects against chemicals, bacteria, viruses, and radiation, J Immunol, vol.180, pp.8280-8285, 2008. ,
DOI : 10.4049/jimmunol.180.12.8280
URL : http://www.jimmunol.org/content/180/12/8280.full.pdf
Toll-like receptor 5 stimulation protects mice from acute Clostridium difficile colitis, Infect Immun, vol.79, pp.1498-503, 2011. ,
Cutting edge: Tlr5-/-mice are more susceptible to Escherichia coli urinary tract infection, J Immunol, vol.178, pp.4717-4737, 2007. ,
DOI : 10.4049/jimmunol.178.8.4717
URL : http://www.jimmunol.org/content/178/8/4717.full.pdf
Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection, Infect Immun, vol.78, pp.4226-4259, 2010. ,
Flagellin stimulates protective lung mucosal immunity: role of cathelicidin-related antimicrobial peptide, J Immunol, vol.185, pp.1142-1151, 2010. ,
Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18, Science, vol.346, pp.861-866, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01290555
Recombinant TLR5 agonist CBLB502 promotes NK cell-mediated anti-CMV immunity in mice, PLoS ONE, vol.9, p.96165, 2014. ,
Flagellin-induced expression of CXCL10 mediates direct fungal killing and recruitment of NK cells to the cornea in response to Candida albicans infection, Eur J Immunol, vol.44, pp.2667-79, 2014. ,
A toll-like receptor 5 agonist improves the efficacy of antibiotics in treatment of primary and influenza virus-associated pneumococcal mouse infections, Antimicrob Agents Chemother, vol.59, pp.6064-72, 2015. ,
Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin, Eur J Immunol, vol.39, pp.1587-96, 2009. ,
Airway structural cells regulate TLR5-mediated mucosal adjuvant activity, Mucosal Immunol, vol.7, pp.489-500, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-00925663
Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract, Vaccine, vol.33, pp.3331-3372, 2015. ,
URL : https://hal.archives-ouvertes.fr/inserm-01182907
Analysis of drug combinations: current methodological landscape, Pharmacol Res Perspect, vol.3, p.149, 2015. ,
Assessment and modelling of antibacterial combination regimens, Clin Microbiol Infect, vol.24, pp.689-96, 2017. ,
When does 2 plus 2 equal 5? A review of antimicrobial synergy testing, J Clin Microbiol, vol.52, pp.4124-4132, 2014. ,
Comparison of techniques for measurement of in vitro antibiotic synergism, J Infect Dis, vol.140, pp.629-662, 1979. ,
Activation of Type 3 innate lymphoid cells and interleukin 22 secretion in the lungs during Streptococcus pneumoniae infection, J Infect Dis, vol.210, pp.493-503, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-01182903
Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages, J Biol Chem, vol.287, pp.8816-8845, 2012. ,
Potential role of invariant NKT cells in the control of pulmonary inflammation and CD8+ T cell response during acute influenza A virus H3N2 pneumonia, J Immunol, vol.186, pp.5590-602, 2011. ,
Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A, Nat Immunol, vol.11, pp.1039-1085, 2010. ,
Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity, J Immunol, vol.181, pp.2036-2079, 2008. ,
Synergy testing of FDA-approved drugs identifies potent drug combinations against Trypanosoma cruzi, PLoS Negl Trop Dis, vol.8, 2014. ,
Both influenza-induced neutrophil dysfunction and neutrophil-independent mechanisms contribute to increased susceptibility to a secondary Streptococcus pneumoniae infection, Infect Immun, vol.74, pp.6707-6728, 2006. ,
Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice, J Immunol, vol.186, pp.1666-74, 2011. ,
Influenza and bacterial superinfection: illuminating the immunologic mechanisms of disease, Infect Immun, vol.83, pp.3764-70, 2015. ,
The co-pathogenesis of influenza viruses with bacteria in the lung, Nat Rev Microbiol, vol.12, pp.252-62, 2014. ,
Mucosal administration of flagellin induces innate immunity in the mouse lung, Infect Immun, vol.72, pp.6676-6685, 2004. ,
Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response, J Immunol, vol.172, pp.6922-6952, 2004. ,
Lung epithelial cells: therapeutically inducible effectors of antimicrobial defense, Mucosal Immunol, vol.11, pp.21-34, 2018. ,
Lung epithelial MyD88 drives early pulmonary clearance of Pseudomonas aeruginosa by a flagellin dependent mechanism, Am J Physiol Lung Cell Mol Physiol, vol.311, pp.219-228, 2016. ,
Understanding the pneumococcus: transmission and evolution, Front Cell Infect Microbiol, 2013. ,
Antibiotic resistance and its cost: is it possible to reverse resistance?, Nat Rev Microbiol, vol.8, pp.260-71, 2010. ,
Clinical applications of population pharmacokinetic models of antibiotics: challenges and perspectives, Pharmacol Res, vol.134, pp.280-288, 2018. ,