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Proteomics Approaches to Define Senescence Heterogeneity and Chemotherapy Response

Coralie Petit 1 Jordan Guillon 1 Bertrand Toutain 1 Alice Boissard 1 Anne Patsouris 1 Eric Lelievre 1 Catherine Guette 1 Olivier Coqueret 1, *
* Corresponding author
1 CRCINA-ÉQUIPE 12 - Senescence Escape and Soluble Markers of Cancer Progression
CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
Abstract : In primary cells, senescence induces a permanent proliferative arrest to prevent the propagation of malignant cells. However, the outcome of senescence is more complex in advanced cancer cells where senescent states are heterogeneous. Here, this heterogeneity is discussed and it is proposed that proteomic analysis should be used to identify specific signatures of cancer cells that use this pathway as an adaptive mechanism. Since senescent cells produce an inflammatory secretome, MRM approaches and quantification with internal standards might be particularly suited to follow the expression of the corresponding markers in body fluids. Used in combination with imaging medical technics, a better characterization of senescence heterogeneity should help to monitor the response to chemotherapy treatment.
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Submitted on : Monday, May 27, 2019 - 10:30:34 AM
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Coralie Petit, Jordan Guillon, Bertrand Toutain, Alice Boissard, Anne Patsouris, et al.. Proteomics Approaches to Define Senescence Heterogeneity and Chemotherapy Response. Proteomics, Wiley-VCH Verlag, 2019, pp.1800447. ⟨10.1002/pmic.201800447⟩. ⟨inserm-02140239⟩

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