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Journal articles
HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1
Abstract : HBO1 histone acetylase is important for DNA replication licensing. In human cells, HBO1 associates with replication origins specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor Cdt1, but is independent of the Cdt1 repressor Geminin. HBO1 directly interacts with Cdt1, and it enhances Cdt1-dependent rereplication. Thus, HBO1 plays a direct role at replication origins as a coactivator of the Cdt1 licensing factor. As HBO1 is also a transcriptional coactivator, it has the potential to integrate internal and external stimuli to coordinate transcriptional responses with initiation of DNA replication.
Cited literature [34 references]
https://www.hal.inserm.fr/inserm-02132585
Contributor : Benoit Miotto <>
Submitted on : Sunday, November 8, 2020 - 9:11:23 PM
Last modification on : Tuesday, November 17, 2020 - 2:10:07 PM
Contributor : Benoit Miotto <>
Submitted on : Sunday, November 8, 2020 - 9:11:23 PM
Last modification on : Tuesday, November 17, 2020 - 2:10:07 PM