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HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1

Abstract : HBO1 histone acetylase is important for DNA replication licensing. In human cells, HBO1 associates with replication origins specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor Cdt1, but is independent of the Cdt1 repressor Geminin. HBO1 directly interacts with Cdt1, and it enhances Cdt1-dependent rereplication. Thus, HBO1 plays a direct role at replication origins as a coactivator of the Cdt1 licensing factor. As HBO1 is also a transcriptional coactivator, it has the potential to integrate internal and external stimuli to coordinate transcriptional responses with initiation of DNA replication.
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Benoit Miotto, Kevin Struhl. HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1. Genes and Development, Cold Spring Harbor Laboratory Press, 2008, 22 (19), pp.2633-2638. ⟨10.1101/gad.1674108⟩. ⟨inserm-02132585⟩



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