O. Hyrien, Peaks cloaked in the mist : the landscape of mammalian replication origins, J Cell Biol, vol.208, pp.147-60, 2015.

J. C. Cadoret, F. Meisch, and V. Hassan-zadeh, Genome-wide studies highlight indirect links between human replication origins and gene regulation, Proc Natl Acad Sci, vol.105, pp.15837-15879, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00332341

E. Besnard, A. Babled, and L. Lapasset, Unraveling cell type-specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs, Nat Struct Mol Biol, vol.19, pp.837-881, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01338204

G. I. Dellino, D. Cittaro, and R. Piccioni, Genome-wide mapping of human DNA-replication origins : levels of transcription at ORC1 sites regulate origin selection and replication timing, Genome Res, vol.23, pp.1-11, 2013.

L. D. Mesner, V. Valsakumar, and M. Cieslik, Bubble-seq analysis of the human genome reveals distinct chromatin-mediated mechanisms for regulating early-and late-firing origins, Genome Res, vol.23, pp.1774-88, 2013.

F. Picard, J. C. Cadoret, and B. Audit, The spatiotemporal program of DNA replication is associated with specific combinations of chromatin marks in human cells, PLoS Genet, vol.10, p.1004282, 2014.
URL : https://hal.archives-ouvertes.fr/hal-00995097

N. Petryk, M. Kahli, D. 'aubenton-carafa, and Y. , Replication landscape of the human genome, Nat Commun, vol.7, p.10208, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01412672

B. Miotto, Z. Ji, and K. Struhl, Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers, Proc Natl Acad Sci, vol.113, pp.4810-4819, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-02132558

A. Letessier, D. Birnbaum, M. Debatisse, and M. Chaffanet, La pauvreté en sites d'initiation de la réplication rend-elle fragile certaines régions du génome ?, Med Sci, vol.27, pp.707-716, 2011.

A. Letessier, G. A. Millot, and S. Koundrioukoff, Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site, Nature, vol.470, pp.120-123, 2011.

T. Ryba, D. Battaglia, and B. H. Chang, Abnormal developmental control of replication-timing domains in pediatric acute lymphoblastic leukemia

, Genome Res, vol.22, pp.1833-1877, 2012.

L. Smith, A. Plug, and M. Thayer, Delayed replication timing leads to delayed mitotic chromosome condensation and chromosomal instability of chromosome translocations, Proc Natl Acad Sci, vol.98, pp.13300-13305, 2001.

P. Polak, . Karlic´rkarlic´r, and A. Koren, Cell-of-origin chromatin organization shapes the mutational landscape of cancer, Nature, vol.518, pp.360-364, 2015.

R. Lombraña, R. Almeida, and I. Revuelta, High-resolution analysis of DNA synthesis start sites and nucleosome architecture at efficient mammalian replication origins, EMBO J, vol.32, pp.2631-2675, 2013.

A. W. Thomae, D. Pich, and J. Brocher, Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins, Proc Natl Acad Sci, vol.105, pp.1692-1699, 2008.

P. Benatti, S. Belluti, and B. Miotto, Direct non transcriptional role of NF-Y in DNA replication, Biochim Biophys Acta, vol.1863, pp.673-85, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-02132560

D. Dominguez-sola, C. Y. Ying, and C. Grandori, Non-transcriptional control of DNA replication by c-Myc, Nature, vol.448, pp.445-51, 2007.

B. Miotto and K. Struhl, HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1, Genes Dev, vol.22, pp.2633-2641, 2008.
URL : https://hal.archives-ouvertes.fr/inserm-02132585

B. Miotto and K. Struhl, Differential gene regulation by selective association of transcriptional coactivators and bZIP DNA-binding domains, Mol Cell Biol, vol.26, pp.5969-82, 2006.
URL : https://hal.archives-ouvertes.fr/inserm-02132531

Y. Feng, A. Vlassis, and C. Roques, BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation, EMBO J, vol.35, pp.176-92, 2016.

B. Miotto and K. Struhl, JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress, Mol Cell, vol.44, pp.62-71, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-02132575

D. Grégoire, K. Brodolin, and M. Méchali, HoxB domain induction silences DNA replication origins in the locus and specifies a single origin at its boundary, EMBO Rep, vol.7, pp.812-818, 2006.

O. Hyrien, C. Maric, and M. Méchali, Transition in specification of embryonic metazoan DNA replication origins, Science, vol.270, pp.994-1001, 1995.

S. K. Powell, H. K. Macalpine, and J. A. Prinz, Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle, EMBO J, vol.34, pp.531-574, 2015.

P. Norio, S. Kosiyatrakul, and Q. Yang, Progressive activation of DNA replication initiation in large domains of the immunoglobulin heavy chain locus during B cell development, Mol Cell, vol.20, pp.575-87, 2005.

J. Gros, C. Kumar, and G. Lynch, Post-licensing Specification of Eukaryotic Replication Origins by Facilitated Mcm2-7 Sliding along DNA, Mol Cell, vol.60, pp.797-807, 2015.

D. Ray-gallet, A. Gérard, S. Polo, and G. Almouzni, Variations sur le thème du code histone, Med Sci (Paris), vol.21, pp.384-393, 2005.

S. P. Bell and A. Dutta, DNA replication in eukaryotic cells, Annu Rev Biochem, vol.71, pp.333-74, 2002.

M. Fragkos, O. Ganier, P. Coulombe, and M. Méchali, DNA replication origin activation in space and time, Nat Rev Mol Cell Biol, vol.16, pp.360-74, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01159618

S. Hoshina, K. Yura, and H. Teranishi, Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA, J Biol Chem, vol.288, pp.30161-71, 2013.

J. Sequeira-mendes and M. Gómez, On the opportunistic nature of transcription and replication initiation in the metazoan genome, Bioessays, vol.34, pp.119-144, 2012.

B. Bartholdy, R. Mukhopadhyay, and J. Lajugie, Allele-specific analysis of DNA replication origins in mammalian cells, Nat Commun, vol.6, p.7051, 2015.

A. L. Valton, V. Hassan-zadeh, and I. Lema, G4 motifs affect origin positioning and efficiency in two vertebrate replicators, EMBO J, vol.33, pp.732-778, 2014.
URL : https://hal.archives-ouvertes.fr/hal-00987430

, Des fragments d'ADN synthétisés par l'ADN polymérase ? modifient notre génome, Med Sci (Paris), vol.31, pp.821-824, 2015.

, RÉFÉRENCES

B. Miotto and K. Struhl, De la régulation du génome à la progression tumorale, Med Sci (Paris), vol.23, pp.735-775, 2007.

L. C. Pradel, L. Vanhille, and S. Spicuglia, Projet européen Blueprint. Med Sci, vol.31, pp.236-244, 2015.

M. Tardat, J. Brustel, and O. Kirsh, The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells, Nat Cell Biol, vol.12, pp.1086-93, 2010.

A. J. Kuo, J. Song, and P. Cheung, The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome, Nature, vol.484, pp.115-124, 2012.

L. S. Bicknell, S. Walker, and A. Klingseisen, Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome, Nat Genet, vol.43, pp.350-355, 2011.

M. Suchyta, B. Miotto, and T. J. Mcgarry, An inactive geminin mutant that binds cdt1, Genes (Basel), vol.6, pp.252-66, 2015.
URL : https://hal.archives-ouvertes.fr/inserm-02132562

B. Miotto and K. Struhl, HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin, Mol Cell, vol.37, pp.57-66, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-02132583