D. Jung, C. Giallourakis, R. Mostoslavsky, and F. W. Alt, Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus, Annu Rev Immunol, vol.24, pp.541-570, 2006.

C. Bossen, R. Mansson, and C. Murre, Chromatin topology and the regulation of antigen receptor assembly, Annu Rev Immunol, vol.30, pp.337-356, 2012.

S. Herzog, M. Reth, and H. Jumaa, Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling, Nat Rev Immunol, vol.9, pp.195-205, 2009.

R. W. Hendriks and S. Middendorp, The pre-BCR checkpoint as a cellautonomous proliferation switch, Trends Immunol, vol.25, pp.249-256, 2004.

S. Jhunjhunwala, M. C. Van-zelm, M. M. Peak, and C. Murre, Chromatin architecture and the generation of antigen receptor diversity, Cell, vol.138, pp.435-448, 2009.

Y. Ji, W. Resch, E. Corbett, A. Yamane, and R. Casellas, The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci, Cell, vol.141, pp.419-431, 2010.

T. Perlot and F. W. Alt, Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus, Adv Immunol, vol.99, pp.1-32, 2008.

R. M. Cobb, K. J. Oestreich, O. A. Osipovich, and E. M. Oltz, Accessibility control of V(D)J recombination, Adv Immunol, vol.91, pp.45-109, 2006.

K. J. Oestreich, R. M. Cobb, S. Pierce, J. Chen, and P. Ferrier, Regulation of TCRbeta gene assembly by a promoter/enhancer holocomplex, Immunity, vol.24, pp.381-391, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00165577

V. C. Seitan, M. S. Krangel, and M. Merkenschlager, Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement, Trends Immunol, vol.33, pp.153-159, 2012.

M. P. Lefranc, V. Giudicelli, Q. Kaas, E. Duprat, and J. Jabado-michaloud, IMGT, the international ImMunoGeneTics information system, Nucleic Acids Res, vol.33, pp.593-597, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00616561

G. D. Yancopoulos and F. W. Alt, Developmentally controlled and tissue-specific expression of unrearranged VH gene segments, Cell, vol.40, pp.271-281, 1985.

I. Abarrategui and M. S. Krangel, Germline transcription: a key regulator of accessibility and recombination, Adv Exp Med Biol, vol.650, pp.93-102, 2009.

M. S. Schlissel and D. Baltimore, Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription, Cell, vol.58, pp.1001-1007, 1989.

C. Murre, Helix-loop-helix proteins and lymphocyte development, Nat Immunol, vol.6, pp.1079-1086, 2005.

S. A. Muljo and M. S. Schlissel, A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines, Nat Immunol, vol.4, pp.31-37, 2003.

R. Lu, K. L. Medina, D. W. Lancki, and H. Singh, IRF-4,8 orchestrate the pre-Bto-B transition in lymphocyte development, Genes Dev, vol.17, pp.1703-1708, 2003.

S. Ma, A. Turetsky, L. Trinh, and R. Lu, IFN regulatory factor 4 and 8 promote Ig light chain kappa locus activation in pre-B cell development, J Immunol, vol.177, pp.7898-7904, 2006.

K. Johnson, T. Hashimshony, C. M. Sawai, J. M. Pongubala, and J. A. Skok, Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling, Immunity, vol.28, pp.335-345, 2008.

Z. Liu, P. Widlak, Y. Zou, F. Xiao, and M. Oh, A recombination silencer that specifies heterochromatin positioning and ikaros association in the immunoglobulin kappa locus, Immunity, vol.24, pp.405-415, 2006.

C. Ribeiro-de-almeida, R. Stadhouders, M. J. De-bruijn, I. M. Bergen, and S. Thongjuea, The DNA-binding protein CTCF limits proximal Vkappa recombination and restricts kappa enhancer interactions to the immunoglobulin kappa light chain locus, Immunity, vol.35, pp.501-513, 2011.

C. Ribeiro-de-almeida, R. Stadhouders, S. Thongjuea, E. Soler, and R. W. Hendriks, DNA-binding factor CTCF and long-range gene interactions in V(D)J recombination and oncogene activation, Blood, vol.119, pp.6209-6218, 2012.

Y. Xiang, X. Zhou, S. L. Hewitt, J. A. Skok, and W. T. Garrard, A multifunctional element in the mouse Igkappa locus that specifies repertoire and Ig loci subnuclear location, J Immunol, vol.186, pp.5356-5366, 2011.

X. Pan, M. Papasani, Y. Hao, M. Calamito, and F. Wei, YY1 controls Igkappa repertoire and B-cell development, and localizes with condensin on the Igkappa locus, EMBO J, vol.32, pp.1168-1182, 2013.

F. Melchers, The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire, Nat Rev Immunol, vol.5, pp.578-584, 2005.

Z. Li, D. I. Dordai, J. Lee, and S. Desiderio, A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle, Immunity, vol.5, pp.575-589, 1996.

E. C. Thompson, B. S. Cobb, P. Sabbattini, S. Meixlsperger, and V. Parelho, Ikaros DNA-binding proteins as integral components of B cell developmentalstage-specific regulatory circuits, Immunity, vol.26, pp.335-344, 2007.

J. Nakayama, M. Yamamoto, K. Hayashi, H. Satoh, and K. Bundo, BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3, Blood, vol.113, pp.1483-1492, 2009.

S. Herzog, E. Hug, S. Meixlsperger, J. H. Paik, and R. A. Depinho, SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway, Nat Immunol, vol.9, pp.623-631, 2008.

R. H. Amin and M. S. Schlissel, Foxo1 directly regulates the transcription of recombination-activating genes during B cell development, Nat Immunol, vol.9, pp.613-622, 2008.

T. I. Novobrantseva, V. M. Martin, R. Pelanda, W. Muller, and K. Rajewsky, Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice, J Exp Med, vol.189, pp.75-88, 1999.

F. Melchers, E. Boekel, T. Seidl, X. C. Kong, and T. Yamagami, Repertoire selection by pre-B-cell receptors and B-cell receptors, and genetic control of B-cell development from immature to mature B cells, Immunol Rev, vol.175, pp.33-46, 2000.

M. S. Schlissel, Regulation of activation and recombination of the murine Igkappa locus, Immunol Rev, vol.200, pp.215-223, 2004.

R. Kersseboom, V. B. Ta, A. J. Zijlstra, S. Middendorp, and H. Jumaa, Bruton's tyrosine kinase and SLP-65 regulate pre-B cell differentiation and the induction of Ig light chain gene rearrangement, J Immunol, vol.176, pp.4543-4552, 2006.

G. M. Dingjan, S. Middendorp, K. Dahlenborg, A. Maas, and F. Grosveld, Bruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouse, J Exp Med, vol.193, pp.1169-1178, 2001.

E. Roldan, M. Fuxa, W. Chong, D. Martinez, and M. Novatchkova, Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene, Nat Immunol, vol.6, pp.31-41, 2005.

M. A. Inlay, H. Tian, T. Lin, and Y. Xu, Important roles for E protein binding sites within the immunoglobulin kappa chain intronic enhancer in activating Vkappa Jkappa rearrangement, J Exp Med, vol.200, pp.1205-1211, 2004.

A. S. Lazorchak, M. S. Schlissel, and Y. Zhuang, E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells, Mol Cell Biol, vol.26, pp.810-821, 2006.

D. Reynaud, I. A. Demarco, K. L. Reddy, H. Schjerven, and E. Bertolino, Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros, Nat Immunol, vol.9, pp.927-936, 2008.

Y. C. Lin, C. Benner, R. Mansson, S. Heinz, and K. Miyazaki, Global changes in the nuclear positioning of genes and intra-and interdomain genomic interactions that orchestrate B cell fate, Nat Immunol, vol.13, pp.1196-1204, 2012.

R. Stadhouders, P. Kolovos, R. Brouwer, J. Zuin, and A. Van-den-heuvel, Multiplexed chromosome conformation capture sequencing for rapid genomescale high-resolution detection of long-range chromatin interactions, Nat Protoc, vol.8, pp.509-524, 2013.

H. Jumaa, B. Wollscheid, M. Mitterer, J. Wienands, and M. Reth, Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65, Immunity, vol.11, pp.547-554, 1999.

S. Middendorp, G. M. Dingjan, and R. W. Hendriks, Impaired precursor B cell differentiation in Bruton's tyrosine kinase-deficient mice, J Immunol, vol.168, pp.2695-2703, 2002.

H. Jumaa, M. Mitterer, M. Reth, and P. J. Nielsen, The absence of SLP65 and Btk blocks B cell development at the preB cell receptor-positive stage, Eur J Immunol, vol.31, pp.2164-2169, 2001.

A. I. Saeed, N. K. Bhagabati, J. C. Braisted, W. Liang, and V. Sharov, microarray software suite, Methods Enzymol, vol.411, pp.134-193, 2006.

R. Kersseboom, S. Middendorp, G. M. Dingjan, K. Dahlenborg, and M. Reth, Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells, J Exp Med, vol.198, pp.91-98, 2003.

B. Bertocci, D. Smet, A. Berek, C. Weill, J. C. Reynaud et al., Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu, Immunity, vol.19, pp.203-211, 2003.

A. S. Baldwin, K. P. Leclair, H. Singh, and P. A. Sharp, A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes, Mol Cell Biol, vol.10, pp.1406-1414, 1990.

H. Engel, A. Rolink, and S. Weiss, B cells are programmed to activate kappa and lambda for rearrangement at consecutive developmental stages, Eur J Immunol, vol.29, pp.2167-2176, 1999.

J. R. Gorman, N. Van-der-stoep, R. Monroe, M. Cogne, and L. Davidson, The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes, Immunity, vol.5, pp.241-252, 1996.

Y. Xu, L. Davidson, F. W. Alt, and D. Baltimore, Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement, Immunity, vol.4, pp.377-385, 1996.

M. Inlay, F. W. Alt, D. Baltimore, and Y. Xu, Essential roles of the kappa light chain intronic enhancer and 39 enhancer in kappa rearrangement and demethylation, Nat Immunol, vol.3, pp.463-468, 2002.

S. Greenbaum and Y. Zhuang, Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system, Proc Natl Acad Sci U S A, vol.99, pp.15030-15035, 2002.

M. Aoki-ota, A. Torkamani, T. Ota, N. Schork, and D. Nemazee, Skewed primary Igkappa repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing, J Immunol, vol.188, pp.2305-2315, 2012.

I. Ferreiros-vidal, C. T. Taylor, B. Terry, A. Liang, and Z. , Genomewide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation, Blood, vol.121, pp.1769-1782, 2013.

Y. C. Lin, S. Jhunjhunwala, C. Benner, S. Heinz, and E. Welinder, A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate, Nat Immunol, vol.11, pp.635-643, 2010.

S. Sakamoto, K. Wakae, Y. Anzai, K. Murai, and N. Tamaki, E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin kappa locus, J Immunol, vol.188, pp.5547-5560, 2012.

B. Heizmann, P. Kastner, and S. Chan, Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals, J Exp Med, 2013.

A. J. Feeney, Epigenetic regulation of antigen receptor gene rearrangement, Curr Opin Immunol, vol.23, pp.171-177, 2011.

Y. Liu, R. Subrahmanyam, T. Chakraborty, R. Sen, and S. Desiderio, A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement, Immunity, vol.27, pp.561-571, 2007.

A. G. Matthews, A. J. Kuo, S. Ramon-maiques, S. Han, and K. S. Champagne, RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination, Nature, vol.450, pp.1106-1110, 2007.

G. Bain, R. Maandag, E. C. Te-riele, H. P. Feeney, A. J. Sheehy et al., Both E12 and E47 allow commitment to the B cell lineage, Immunity, vol.6, pp.145-154, 1997.

M. Goldmit, Y. Ji, J. Skok, E. Roldan, and S. Jung, Epigenetic ontogeny of the Igk locus during B cell development, Nat Immunol, vol.6, pp.198-203, 2005.

S. C. Degner, J. Verma-gaur, T. P. Wong, C. Bossen, and G. M. Iverson, CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells, Proc Natl Acad Sci U S A, vol.108, pp.9566-9571, 2011.

C. Guo, H. S. Yoon, A. Franklin, S. Jain, and A. Ebert, CTCF-binding elements mediate control of V(D)J recombination, Nature, vol.477, pp.424-430, 2011.

C. R. Xu and A. J. Feeney, The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling, J Immunol, vol.182, pp.1362-1369, 2009.

M. A. Inlay, T. Lin, H. H. Gao, and Y. Xu, Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci, J Exp Med, vol.203, pp.1721-1732, 2006.

K. E. Brown, S. S. Guest, S. T. Smale, K. Hahm, and M. Merkenschlager, Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin, Cell, vol.91, pp.845-854, 1997.

J. Kim, S. Sif, B. Jones, A. Jackson, and J. Koipally, Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes, Immunity, vol.10, pp.345-355, 1999.

J. Koipally, A. Renold, J. Kim, and K. Georgopoulos, Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes, EMBO J, vol.18, pp.3090-3100, 1999.

C. Schmitt, C. Tonnelle, A. Dalloul, C. Chabannon, and P. Debre, Aiolos and Ikaros: regulators of lymphocyte development, homeostasis and lymphoproliferation, Apoptosis, vol.7, pp.277-284, 2002.

S. J. Holwerda, H. J. Van-de-werken, R. De-almeida, C. Bergen, I. M. De-bruijn et al., Allelic exclusion of the immunoglobulin heavy chain locus is independent of its nuclear localization in mature B cells, Nucleic Acids Res, vol.41, pp.6905-6916, 2013.

F. Martin, X. Chen, and J. F. Kearney, Development of VH81X transgenebearing B cells in fetus and adult: sites for expansion and deletion in conventional and CD5/B1 cells, Int Immunol, vol.9, pp.493-505, 1997.

P. Mombaerts, J. Iacomini, R. S. Johnson, K. Herrup, and S. Tonegawa, RAG-1-deficient mice have no mature B and T lymphocytes, Cell, vol.68, pp.869-877, 1992.

R. W. Hendriks, M. F. De-bruijn, A. Maas, G. M. Dingjan, and A. Karis, Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage, EMBO J, vol.15, pp.4862-4872, 1996.

R. Stadhouders, S. Thongjuea, C. Andrieu-soler, R. J. Palstra, and J. C. Bryne, Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development, EMBO J, vol.31, pp.986-999, 2012.

S. Thongjuea, R. Stadhouders, F. G. Grosveld, E. Soler, and B. Lenhard, r3Cseq: an R/Bioconductor package for the discovery of long-range genomic interactions from chromosome conformation capture and next-generation sequencing data, Nucleic Acids Res, vol.41, p.132, 2013.

T. Ikawa, H. Kawamoto, L. Y. Wright, and C. Murre, Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent, Immunity, vol.20, pp.349-360, 2004.

C. E. Sayegh, S. Jhunjhunwala, R. Riblet, and C. Murre, Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells, Genes Dev, vol.19, pp.322-327, 2005.