R. Pearlman, W. L. Frankel, B. Swanson, W. Zhao, A. Yilmaz et al., Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer, JAMA Oncol, vol.3, issue.4, 2017.

S. Shiovitz and L. A. Korde, Genetics of breast cancer: a topic in evolution, Ann Oncol, vol.26, issue.7, pp.1291-1300, 2015.

R. Wooster, S. L. Neuhausen, J. Mangion, Y. Quirk, D. Ford et al., Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13, Science, vol.265, issue.5181, pp.2088-90, 1994.

Y. C. Hsieh, S. H. Tu, C. T. Su, E. C. Cho, C. H. Wu et al., A polygenic risk score for breast cancer risk in a Taiwanese population, Breast Cancer Res Treat, vol.163, issue.1, 2017.

J. Long, Q. Cai, H. Sung, J. Shi, B. Zhang et al., American Association for Cancer clincancerres.aacrjournals.org Downloaded from Author manuscripts have been peer reviewed and accepted for publication, PLoS Genet, vol.8, issue.2, 2012.

, Author Manuscript Published OnlineFirst on, 2019.

B. Zhang, A. Beeghly-fadiel, J. Long, and W. Zheng, Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence, Lancet Oncol, vol.12, issue.5, pp.70076-70082, 2011.

S. Pena-llopis, S. Vega-rubin-de-celis, A. Liao, N. Leng, P. et al., BAP1 loss defines a new class of renal cell carcinoma, Nat Genet, vol.44, issue.7, 2012.

M. N. Farley, L. S. Schmidt, J. L. Mester, S. Pena-llopis, P. et al., A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma, Mol Cancer Res, vol.11, issue.9, 2013.

D. Aletaha, T. Neogi, A. J. Silman, J. Funovits, D. T. Felson et al., , 2010.

, Rheumatoid arthritis classification criteria: an American College of

, Rheumatology/European League Against Rheumatism collaborative initiative

, Arthritis Rheum, vol.62, issue.9, 2010.

K. Matsumoto, M. Umitsu, D. Silva, D. M. Roy, A. Bottaro et al., Hepatocyte growth factor/MET in cancer progression and biomarker discovery, Cancer Sci, vol.108, issue.3, pp.296-307, 2017.

P. Peschard, T. M. Fournier, L. Lamorte, M. A. Naujokas, H. Band et al., Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein, Mol Cell, vol.8, issue.5, pp.995-1004, 2001.

M. Kong-beltran, S. Seshagiri, J. Zha, W. Zhu, K. Bhawe et al., Somatic mutations lead to an oncogenic deletion of met in lung cancer, Cancer Res, vol.13

P. Fallahi, S. M. Ferrari, I. Ruffilli, G. Elia, M. Biricotti et al., The association of other autoimmune diseases in patients with autoimmune thyroiditis: Review of the literature and report of a large series of patients, Autoimmun Rev, vol.15, issue.12, 2016.

J. M. Sabio, E. Milla, and J. Jimenez-alonso, A multicase family with primary Sjogren's syndrome, J Rheumatol, vol.28, issue.8, pp.1932-1936, 2001.

C. J. Lessard, H. Li, I. Adrianto, J. A. Ice, A. Rasmussen et al., Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome, Nat Genet, vol.45, issue.11, 2013.

Y. Li, K. Zhang, H. Chen, F. Sun, J. Xu et al., A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23, Nat Genet, vol.45, issue.11, 2013.

P. K. Gregersen, J. Silver, and R. J. Winchester, The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis, Arthritis Rheum, vol.30, issue.11, pp.1205-1218, 1987.

P. A. Gourraud, P. Dieude, J. F. Boyer, L. Nogueira, A. Cambon-thomsen et al., A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis, Arthritis Res Ther, vol.9, issue.2, 2007.
URL : https://hal.archives-ouvertes.fr/hal-02084374

B. D. Korman, D. L. Kastner, P. K. Gregersen, and E. F. Remmers, STAT4: genetics, mechanisms, and implications for autoimmunity, Curr Allergy Asthma Rep, vol.8, issue.5, pp.398-403, 2008.

C. R. Graveel, D. Tolbert, V. Woude, and G. F. , American Association for Cancer clincancerres.aacrjournals.org Downloaded from different role of C-reactive protein and pentraxin 3, Cold Spring Harb Perspect Biol, vol.5, issue.7, 2011.

W. Tapper, A. V. Jones, R. Kralovics, A. S. Harutyunyan, K. Zoi et al., Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms, Nat Commun, vol.6, 2015.

G. M. Balarini, E. Zandonade, L. Tanure, G. A. Ferreira, W. M. Sardenberg et al., Serum calprotectin is a biomarker of carotid atherosclerosis in patients with primary Sjogren's syndrome, Clin Exp Rheumatol, vol.34, issue.6, pp.1006-1018, 2016.

M. Boissinot, C. Cleyrat, M. Vilaine, Y. Jacques, I. Corre et al., Antiinflammatory cytokines hepatocyte growth factor and interleukin-11 are overexpressed in Polycythemia vera and contribute to the growth of clonal erythroblasts independently of JAK2V617F, Oncogene, vol.30, issue.8, 2011.

C. S. Cooper, M. Park, D. G. Blair, M. A. Tainsky, K. Huebner et al., Molecular cloning of a new transforming gene from a chemically transformed human cell line, Nature, vol.311, issue.5981, pp.29-33, 1984.

L. Schmidt, F. M. Duh, F. Chen, T. Kishida, G. Glenn et al., Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas, Nat Genet, vol.16, issue.1, 1997.

L. Schmidt, K. Junker, G. Weirich, G. Glenn, P. Choyke et al., Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene, Cancer Res, vol.58, issue.8, pp.1719-1741, 1998.

J. Verine, A. Pluvinage, G. Bousquet, J. Lehmann-che, C. De-bazelaire et al., American Association for Cancer clincancerres.aacrjournals.org Downloaded from Author manuscripts have been peer reviewed and accepted for publication, Eur Urol, vol.58, issue.5, 2010.

, Cancer Genome Atlas Research N. Comprehensive molecular profiling of lung adenocarcinoma, Nature, vol.511, issue.7511, 2014.

T. Reungwetwattana and S. H. Ou, MET exon 14 deletion (METex14): finally, a frequentenough actionable oncogenic driver mutation in non-small cell lung cancer to lead MET inhibitors out of "40 years of wilderness" and into a clear path of regulatory approval, Transl Lung Cancer Res, vol.4, issue.6, 2015.

J. W. Tyner, L. B. Fletcher, E. Q. Wang, W. F. Yang, M. L. Rutenberg-schoenberg et al., MET receptor sequence variants R970C and T992I lack transforming capacity, Cancer Res, vol.70, issue.15, pp.6233-6240, 2010.

J. M. Boland, J. S. Jang, J. Li, A. M. Lee, J. A. Wampfler et al., MET and EGFR mutations identified in ALK-rearranged pulmonary adenocarcinoma: molecular analysis of 25 ALK-positive cases, J Thorac Oncol, vol.8, issue.5, 2013.

X. Lai, Y. Xia, B. Zhang, J. Li, and Y. Jiang, A meta-analysis of Hashimoto's thyroiditis and papillary thyroid carcinoma risk, Oncotarget, 2017.

C. Cataisson, A. M. Michalowski, K. Shibuya, A. Ryscavage, M. Klosterman et al., MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis, Sci Signal, vol.9, issue.433, 2016.

C. R. Graveel, J. D. Degroot, Y. Su, J. Koeman, K. Dykema et al., Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer, Proc Natl Acad Sci U S A, vol.106, issue.31, 2009.

J. Ma, M. C. Defrances, C. Zou, C. Johnson, R. Ferrell et al., American Association for Cancer clincancerres.aacrjournals.org Downloaded from Author manuscripts have been peer reviewed and accepted for publication, 2019.

, causes its aberrant expression in human breast cancer, J Clin Invest, vol.119, issue.3, 2009.

M. Borset, L. E. Espevik, T. Helseth, E. Waage, A. Sundan et al., Concomitant expression of hepatocyte growth factor/scatter factor and the receptor c-MET in human myeloma cell lines, J Biol Chem, vol.271, issue.40, pp.24655-61, 1996.

A. Ferrucci, M. Moschetta, M. A. Frassanito, S. Berardi, I. Catacchio et al.,

, HGF/cMET autocrine loop is operative in multiple myeloma bone marrow endothelial cells and may represent a novel therapeutic target, Clin Cancer Res, vol.20, issue.22, 2014.

K. Krzystolik, A. Jakubowska, J. Gronwald, M. R. Krawczynski, and M. Drobek-slowik,

L. Sagan, Large deletion causing von Hippel-Lindau disease and hereditary breast cancer syndrome, Hered Cancer Clin Pract, vol.12, issue.1, pp.16-26, 2014.