 |
Journal articles
Targeting Cancer Stem Cells to Overcome Chemoresistance
Abstract : Cancers are heterogeneous at the cell level, and the mechanisms leading to cancer heterogeneity could be clonal evolution or cancer stem cells. Cancer stem cells are resistant to most anti-cancer treatments and could be preferential targets to reverse this resistance, either targeting stemness pathways or cancer stem cell surface markers. Gold nanoparticles have emerged as innovative tools, particularly for photo-thermal therapy since they can be excited by laser to induce hyperthermia. Gold nanoparticles can be functionalized with antibodies to specifically target cancer stem cells. Preclinical studies using photo-thermal therapy have demonstrated the feasibility of targeting chemo-resistant cancer cells to reverse clinical chemoresistance. Here, we review the data linking cancer stem cells and chemoresistance and discuss the way to target them to reverse resistance. We particularly focus on the use of functionalized gold nanoparticles in the treatment of chemo-resistant metastatic cancers.
Cited literature [257 references]
https://www.hal.inserm.fr/inserm-02124684
Contributor : Philippe Ratajczak <>
Submitted on : Thursday, May 9, 2019 - 6:02:04 PM
Last modification on : Friday, October 23, 2020 - 4:51:31 PM
Contributor : Philippe Ratajczak <>
Submitted on : Thursday, May 9, 2019 - 6:02:04 PM
Last modification on : Friday, October 23, 2020 - 4:51:31 PM
File
ijms-19-04036.pdf
Publisher files allowed on an open archive