Targeting Cancer Stem Cells to Overcome Chemoresistance

Toni Nunes 1, 2 Diaddin Hamdan 1 Christophe Leboeuf 2, 1 Morad El Bouchtaoui 1, 2 Guillaume Gapihan 1, 2 Thi Nguyen 1 Solveig Meles 1 Eurydice Angeli 1 Philippe Ratajczak 1, 2 He Lu 1, 2 Melanie Di Benedetto 1, 2, 3 Guilhem Bousquet 1, 2, 4, * Anne Janin 1, 2, *
* Corresponding author
1 UMR 1165 - Cancer et Transplantation : Physiopathologie et Réponse Thérapeutique
2 Laboratoire de pathologie [AP-HP Hôpital Saint-Louis]
3 UP13 - Université Paris 13
4 Service d'Oncologie Médicale [AP-HP Hôpital Avicenne]
Abstract : Cancers are heterogeneous at the cell level, and the mechanisms leading to cancer heterogeneity could be clonal evolution or cancer stem cells. Cancer stem cells are resistant to most anti-cancer treatments and could be preferential targets to reverse this resistance, either targeting stemness pathways or cancer stem cell surface markers. Gold nanoparticles have emerged as innovative tools, particularly for photo-thermal therapy since they can be excited by laser to induce hyperthermia. Gold nanoparticles can be functionalized with antibodies to specifically target cancer stem cells. Preclinical studies using photo-thermal therapy have demonstrated the feasibility of targeting chemo-resistant cancer cells to reverse clinical chemoresistance. Here, we review the data linking cancer stem cells and chemoresistance and discuss the way to target them to reverse resistance. We particularly focus on the use of functionalized gold nanoparticles in the treatment of chemo-resistant metastatic cancers.
Keywords : cancer cancer stem cell chemoresistance functionalization gold nanoparticles photo-thermal therapy
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Toni Nunes, Diaddin Hamdan, Christophe Leboeuf, Morad El Bouchtaoui, Guillaume Gapihan, et al.. Targeting Cancer Stem Cells to Overcome Chemoresistance. International Journal of Molecular Sciences, MDPI, 2018, 19 (12), pp.4036. ⟨10.3390/ijms19124036⟩. ⟨inserm-02124684⟩

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