D. J. Selkoe, Alzheimer's disease is a synaptic failure, Science, vol.298, issue.5594, pp.789-791, 2002.

J. H. Morrison and P. R. Hof, Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease, Prog Brain Res, pp.136467-486, 2002.

J. J. Palop, J. Chin, E. D. Roberson, and . Others, Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease, Neuron, vol.55, issue.5, pp.697-711, 2007.

C. Iadecola, Neurovascular regulation in the normal brain and in Alzheimer's disease, Nat Rev Neurosci, vol.5, issue.5, pp.347-360, 2004.

B. Cauli and E. Hamel, Revisiting the role of neurons in neurovascular coupling, Front Neuroenergetics, vol.29, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00500622

C. Lecrux and E. Hamel, The neurovascular unit in brain function and disease, Acta Physiol (Oxf), vol.203, issue.1, pp.47-59, 2011.

C. Hock, K. Villringer, F. Muller-spahn, and . Others, Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy (NIRS)--correlation with simultaneous rCBF-PET measurements, Brain Res, vol.755, issue.2, pp.293-303, 1997.

M. J. Mentis, G. E. Alexander, and K. J. Others, Increasing required neural response to expose abnormal brain function in mild versus moderate or severe Alzheimer's disease: PET study using parametric visual stimulation, Am J Psychiatry, vol.155, issue.6, pp.785-794, 1998.

S. A. Rombouts and F. Barkhof, Veltman DJ and others. Functional MR imaging in Alzheimer's disease during memory encoding, AJNR Am J Neuroradiol, vol.21, issue.10, pp.1869-1875, 2000.

B. V. Zlokovic, Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders, Nat Rev Neurosci, vol.12, issue.12, pp.723-738, 2011.

E. Hamel, N. Nicolakakis, T. Aboulkassim, B. Ongali, and X. K. Tong, Oxidative stress and cerebrovascular dysfunction in mouse models of Alzheimer's disease, Exp Physiol, vol.93, issue.1, pp.116-120, 2008.

C. Iadecola, F. Zhang, and N. K. Others, SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein, Nat Neurosci, vol.2, issue.2, pp.157-161, 1999.

N. Nicolakakis and E. Hamel, Neurovascular function in Alzheimer's disease patients and experimental models, J Cereb Blood Flow Metab, 2011.

J. Shi, G. Perry, M. A. Smith, and R. P. Friedland, Vascular abnormalities: the insidious pathogenesis of Alzheimer's disease, Neurobiol Aging, vol.21, issue.2, pp.357-361, 2000.

W. R. Brown and C. R. Thore, Review: Cerebral microvascular pathology in aging and neurodegeneration, Neuropathol Appl Neurobiol, 2010.

J. C. De-la-torre, Vascular basis of Alzheimer's pathogenesis, Ann N Y Acad Sci, pp.977196-215, 2002.

B. V. Zlokovic, Neurovascular mechanisms of Alzheimer's neurodegeneration, Trends Neurosci, vol.28, issue.4, pp.202-208, 2005.

E. Benarroch, Neurovascular unit dysfunction: A vascular component of Alzheimer disease, Neurology, vol.68, pp.1730-1732, 2007.

V. Blanchard, S. Moussaoui, and C. C. Others, Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice, Exp Neurol, vol.184, issue.1, pp.247-263, 2003.

S. Narumiya, N. Hirata, and N. T. Others, Structure and function of prostanoid receptors, J Lipid Mediat, vol.6, issue.1-3, pp.155-161, 1993.

B. Cauli and X. K. Tong, Rancillac A and others. Cortical GABA interneurons in neurovascular coupling: relays for subcortical vasoactive pathways, J Neurosci, vol.24, issue.41, pp.8940-8949, 2004.

A. Rancillac, J. Rossier, and G. M. Others, Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum, J Neurosci, vol.26, issue.26, pp.6997-7006, 2006.

J. T. Porter, B. Cauli, and T. K. Others, Selective excitation of subtypes of neocortical interneurons by nicotinic receptors, J Neurosci, vol.19, issue.13, pp.5228-5235, 1999.

Z. Xiang, J. R. Huguenard, and D. A. Prince, Cholinergic switching within neocortical inhibitory networks, Science, vol.281, issue.5379, pp.985-988, 1998.

A. T. Gulledge, S. B. Park, Y. Kawaguchi, and G. J. Stuart, Heterogeneity of phasic cholinergic signaling in neocortical neurons, J Neurophysiol, vol.97, issue.3, pp.2215-2229, 2007.

D. M. Wilcock, M. N. Gordon, and D. Morgan, Quantification of cerebral amyloid angiopathy and parenchymal amyloid plaques with Congo red histochemical stain, Nat Protoc, vol.1, issue.3, pp.1591-1595, 2006.

N. Nishimura, C. B. Schaffer, B. Friedman, P. D. Lyden, and D. Kleinfeld, Penetrating arterioles are a bottleneck in the perfusion of neocortex, Proc Natl Acad Sci U S A, vol.104, issue.1, pp.365-370, 2007.

S. Lee, J. Hjerling-leffler, E. Zagha, G. Fishell, and R. B. , The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors, J Neurosci, vol.30, issue.50, pp.16796-16808, 2010.

Q. Perrenoud, J. Rossier, I. Férézou, H. Geoffroy, T. Gallopin et al., Activation of cortical 5-HT(3) receptor-expressing interneurons induces NO mediated vasodilatations and NPY mediated vasoconstrictions, Front Neural Circuits, vol.6, p.50, 2012.
URL : https://hal.archives-ouvertes.fr/inserm-02119566

R. Abounader, A. Elhusseiny, Z. Cohen, and . Others, Expression of neuropeptide Y receptors mRNA and protein in human brain vessels and cerebromicrovascular cells in culture, J Cereb Blood Flow Metab, vol.19, issue.2, pp.155-163, 1999.

J. Li, Y. J. Wang, M. Zhang, and . Others, Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease, Neurology, vol.76, issue.17, pp.1485-1491, 2011.

D. S. Yang and A. Kumar, Stavrides P and others. Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease, Am J Pathol, vol.173, issue.3, pp.665-681, 2008.

D. G. Cook, M. S. Forman, and S. J. Others, Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells, Nat Med, vol.3, issue.9, pp.1021-1023, 1997.

T. Hartmann, S. C. Bieger, B. Bruhl, and . Others, Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides, Nat Med, vol.3, issue.9, pp.1016-1020, 1997.

H. Xu, D. Sweeney, and W. R. Others, Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation, Proc Natl Acad Sci U S A, vol.94, issue.8, pp.3748-3752, 1997.

J. P. Greenfield, J. Tsai, G. Gk, and . Others, Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides, Proc Natl Acad Sci U S A, vol.96, issue.2, pp.742-747, 1999.

D. Langui, N. Girardot, E. Hachimi, and K. H. Others, Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice, Am J Pathol, vol.165, issue.5, pp.1465-1477, 2004.

C. Schmitz, B. P. Rutten, and P. A. Others, Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease, Am J Pathol, vol.164, issue.4, pp.1495-1502, 2004.

I. Moreno-gonzalez, D. Baglietto-vargas, . Sanchez-varo-r, and . Others, Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice, J Alzheimers Dis, vol.18, issue.4, pp.755-776, 2009.

R. A. Nixon, J. Wegiel, A. Kumar, and . Others, Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study, J Neuropathol Exp Neurol, vol.64, issue.2, pp.113-122, 2005.

W. H. Yu, A. M. Cuervo, A. Kumar, and . Others, Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease, J Cell Biol, vol.171, issue.1, pp.87-98, 2005.

O. Wirths, J. Weis, J. Szczygielski, G. Multhaup, and T. A. Bayer, Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease, Acta Neuropathol, vol.111, issue.4, pp.312-319, 2006.

K. Niwa, L. Younkin, and E. C. Others, Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation, Proc Natl Acad Sci U S A, vol.97, issue.17, pp.9735-9740, 2000.

R. Christie, M. Yamada, M. Moskowitz, and B. Hyman, Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy, Am J Pathol, vol.158, issue.3, pp.1065-1071, 2001.

K. Niwa, K. Kazama, S. G. Younkin, G. A. Carlson, and C. Iadecola, Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein, Neurobiol Dis, vol.9, issue.1, pp.61-68, 2002.

N. T. El-tayara, B. Delatour, A. Volk, and M. Dhenain, Detection of vascular alterations by in vivo magnetic resonance angiography and histology in APP/PS1 mouse model of Alzheimer's disease, MAGMA, vol.23, issue.1, pp.53-64, 2010.

J. C. De-la-torre and T. Mussivand, Can disturbed brain microcirculation cause Alzheimer's disease?, Neurol Res, vol.15, issue.3, pp.146-153, 1993.

B. Ramos and D. Baglietto-vargas, Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease, Neurobiol Aging, vol.27, issue.11, pp.1658-1672, 2006.

P. J. Whitehouse and K. S. Au, Cholinergic receptors in aging and Alzheimer's disease, Prog Neuropsychopharmacol Biol Psychiatry, vol.10, issue.3-5, pp.665-676, 1986.

J. R. James and A. Nordberg, Genetic and environmental aspects of the role of nicotinic receptors in neurodegenerative disorders: emphasis on Alzheimer's disease and Parkinson's disease, Behav Genet, vol.25, issue.2, pp.149-159, 1995.

R. Abounader, J. G. Villemure, and E. Hamel, Characterization of neuropeptide Y (NPY) receptors in human cerebral arteries with selective agonists and the new Y1 antagonist BIBP 3226, Br J Pharmacol, vol.116, issue.4, pp.2245-2250, 1995.

R. G. Dacey, J. E. Bassett, and M. Takayasu, Vasomotor responses of rat intracerebral arterioles to vasoactive intestinal peptide, substance P, neuropeptide Y, and bradykinin, J Cereb Blood Flow Metab, vol.8, issue.2, pp.254-261, 1988.

G. Yang, G. Chen, T. J. Ebner, and C. Iadecola, Nitric oxide is the predominant mediator of cerebellar hyperemia during somatosensory activation in rats, Am J Physiol, vol.277, issue.6, pp.1760-1770, 1999.

G. Yang, J. M. Huard, A. J. Beitz, M. E. Ross, and C. Iadecola, Stellate neurons mediate functional hyperemia in the cerebellar molecular layer, J Neurosci, vol.20, issue.18, pp.6968-6973, 2000.

L. A. Brown, B. J. Key, and T. A. Lovick, Fluorescent imaging of nitric oxide production in neuronal varicosities associated with intraparenchymal arterioles in rat hippocampal slices, Neurosci Lett, vol.294, issue.1, pp.9-12, 2000.

T. A. Lovick, L. A. Brown, and B. J. Key, Neurovascular relationships in hippocampal slices: physiological and anatomical studies of mechanisms underlying flow-metabolism coupling in intraparenchymal microvessels, Neuroscience, vol.92, issue.1, pp.47-60, 1999.

C. Estrada and J. Defelipe, Nitric oxide-producing neurons in the neocortex: morphological and functional relationship with intraparenchymal microvasculature, Cereb Cortex, vol.8, issue.3, pp.193-203, 1998.

X. K. Tong and E. Hamel, Basal forebrain nitric oxide synthase (NOS)-containing neurons project to microvessels and NOS neurons in the rat neocortex: cellular basis for cortical blood flow regulation, Eur J Neurosci, vol.12, issue.8, pp.2769-2780, 2000.

X. Liu, C. Li, F. Jr, and . Others, Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex, Am J Physiol Heart Circ Physiol, vol.295, issue.2, pp.619-631, 2008.

S. Pogun, S. Demirgoren, and T. D. Others, Nicotine modulates nitric oxide in rat brain, Eur Neuropsychopharmacol, vol.10, issue.6, pp.463-472, 2000.

G. C. Petzold and V. N. Murthy, Role of astrocytes in neurovascular coupling, Neuron, vol.71, issue.5, pp.782-797, 2011.

J. Garthwaite and C. L. Boulton, Nitric oxide signaling in the central nervous system, Annu Rev Physiol, pp.57683-706, 1995.

S. R. Jaffrey and S. H. Snyder, Nitric oxide: a neural messenger, Annu Rev Cell Dev Biol, pp.11417-440, 1995.

I. Fleming, Cytochrome p450 and vascular homeostasis, Circ Res, vol.89, issue.9, pp.753-762, 2001.

Y. Fujimoto, E. Uno, and S. Sakuma, Effects of reactive oxygen and nitrogen species on cyclooxygenase-1 and -2 activities, Prostaglandins Leukot Essent Fatty Acids, vol.71, issue.5, pp.335-340, 2004.

D. Salvemini, Regulation of cyclooxygenase enzymes by nitric oxide, Cell Mol Life Sci, vol.53, issue.7, pp.576-582, 1997.

N. J. Willmott, K. Wong, and A. J. Strong, A fundamental role for the nitric oxide-G-kinase signaling pathway in mediating intercellular Ca(2+) waves in glia, J Neurosci, vol.20, issue.5, pp.1767-1779, 2000.

N. Calcinaghi, R. Jolivet, W. Mt, and . Others, Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response, J Cereb Blood Flow Metab, vol.31, issue.9, pp.1-10, 2011.

X. Wang, N. Lou, Q. Xu, and . Others, Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo, Nat Neurosci, vol.9, issue.6, pp.816-823, 2006.