D. G. Schatz and Y. Ji, Recombination centres and the orchestration of V(D)J recombination, Nat Rev Immunol, vol.11, issue.4, pp.251-63, 2011.

A. Martin and M. D. Scharff, Somatic hypermutation of the AID transgene in B and non-B cells, Proc Natl Acad Sci U S A, vol.99, pp.12304-12312, 2002.

M. Muramatsu, K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai et al., Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme, Cell, vol.102, issue.5, pp.553-63, 2000.

S. C. Williams, J. P. Frippiat, I. M. Tomlinson, O. Ignatovich, M. P. Lefranc et al., Sequence and evolution of the human germline V lambda repertoire, J Mol Biol, vol.264, issue.2, pp.220-252, 1996.
URL : https://hal.archives-ouvertes.fr/hal-02194147

J. J. Calis and B. R. Rosenberg, Characterizing immune repertoires by high throughput sequencing: strategies and applications, Trends Immunol, vol.35, issue.12, pp.581-90, 2014.

D. Corti, J. P. Langedijk, A. Hinz, M. S. Seaman, F. Vanzetta et al., Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals, PLoS One, vol.5, issue.1, p.8805, 2010.

D. Corti, J. Voss, S. J. Gamblin, G. Codoni, A. Macagno et al., A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza a hemagglutinins, Science, vol.333, issue.6044, pp.850-856, 2011.

M. C. Devilder, M. Moyon, X. Saulquin, and L. Gautreau-rolland, Generation of discriminative human monoclonal antibodies from rare antigen-specific B cells circulating in blood, J Vis Exp, issue.132, 2018.
URL : https://hal.archives-ouvertes.fr/inserm-01745629

B. Franz, K. F. May, G. Dranoff, and K. Wucherpfennig, Ex vivo characterization and isolation of rare memory B cells with antigen tetramers, Blood, vol.118, issue.2, pp.348-57, 2011.

L. H. Ouisse, L. Gautreau-rolland, M. C. Devilder, M. Osborn, M. Moyon et al., Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile method for the generation of high affinity and discriminative human monoclonal antibodies, BMC Biotechnol, vol.17, issue.1, p.3, 2017.
URL : https://hal.archives-ouvertes.fr/inserm-01444749

H. R. Hoogenboom, Selecting and screening recombinant antibody libraries, Nat Biotechnol, vol.23, issue.9, pp.1105-1121, 2005.

Y. Akamatsu, K. Pakabunto, Z. Xu, Y. Zhang, and N. Tsurushita, Whole IgG surface display on mammalian cells: application to isolation of neutralizing chicken monoclonal anti-IL-12 antibodies, J Immunol Methods, vol.327, issue.1-2, pp.40-52, 2007.

T. S. Al-qaisi, Y. C. Su, and S. R. Roffler, Transient AID expression for in situ mutagenesis with improved cellular fitness, Sci Rep, vol.8, issue.1, p.9413, 2018.

L. An, C. Chen, R. Luo, Y. Zhao, and H. Hang, Activation-induced cytidine deaminase aided in vitro antibody evolution, Methods Mol Biol, vol.1707, pp.1-14, 2018.

P. M. Bowers, R. A. Horlick, T. Y. Neben, R. M. Toobian, G. L. Tomlinson et al., Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies, Proc Natl Acad Sci, vol.108, issue.51, pp.20455-60, 2011.

M. Ho, S. Nagata, and I. Pastan, Isolation of anti-CD22 Fv with high affinity by Fv display on human cells, Proc Natl Acad Sci, vol.103, issue.25, pp.9637-9679, 2006.

M. Ho and I. Pastan, Display and selection of scFv antibodies on HEK-293T cells, Methods Mol Biol, vol.562, pp.99-113, 2009.

A. D. Mcconnell, M. Do, T. Y. Neben, V. Spasojevic, J. Maclaren et al., High affinity humanized antibodies without making hybridomas; immunization paired with mammalian cell display and in vitro somatic hypermutation, PLoS One, vol.7, issue.11, p.49458, 2012.

Y. C. Su, T. S. Al-qaisi, H. Y. Tung, T. L. Cheng, K. H. Chuang et al., Mimicking the germinal center reaction in hybridoma cells to isolate temperature-selective anti-PEG antibodies, mAbs, vol.6, issue.4, pp.1069-83, 2014.

L. Wang, W. C. Jackson, P. A. Steinbach, and R. Y. Tsien, Evolution of new nonantibody proteins via iterative somatic hypermutation, Proc Natl Acad Sci U S A, vol.101, issue.48, pp.16745-16754, 2004.

J. K. Hwang, F. W. Alt, and L. S. Yeap, Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination, Microbiol Spectr, vol.2015, issue.1, pp.3-0037

G. T. Hess, J. Tycko, D. Yao, and M. C. Bassik, Methods and applications of CRISPRMediated Base editing in eukaryotic genomes, Mol Cell, vol.68, issue.1, pp.26-43, 2017.

H. A. Rees and D. R. Liu, Base editing: precision chemistry on the genome and transcriptome of living cells, Nat Rev Genet, vol.19, issue.12, pp.770-88, 2018.

G. T. Hess, L. Fresard, K. Han, C. H. Lee, A. Li et al., Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells, Nat Methods, vol.13, issue.12, pp.1036-1078, 2016.

J. L. Yates, N. Warren, and B. Sugden, Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells, Nature, vol.313, issue.6005, pp.812-817, 1985.

S. J. Cumbers, G. T. Williams, S. L. Davies, R. L. Grenfell, S. Takeda et al., Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines, Nat Biotechnol, vol.20, issue.11, pp.1129-1163, 2002.

R. K. Delker, S. D. Fugmann, and F. N. Papavasiliou, A coming-of-age story: activationinduced cytidine deaminase turns 10, Nat Immunol, vol.10, issue.11, pp.1147-53, 2009.

R. W. Maul and P. J. Gearhart, AID and somatic hypermutation, Adv Immunol, vol.105, pp.159-91, 2010.

H. Seo, S. Hashimoto, K. Tsuchiya, W. Lin, T. Shibata et al., An ex vivo method for rapid generation of monoclonal antibodies (ADLib system), Nat Protoc, vol.1, issue.3, pp.1502-1508, 2006.

D. M. Mason, C. R. Weber, C. Parola, S. M. Meng, V. Greiff et al., High-throughput antibody engineering in mammalian cells by CRISPR/Cas9-mediated homology-directed mutagenesis, Nucleic Acids Res, vol.46, issue.14, pp.7436-7485, 2018.

K. E. Tiller, R. Chowdhury, T. Li, S. D. Ludwig, S. Sen et al., Facile affinity maturation of antibody variable domains using natural diversity mutagenesis, Front Immunol, vol.8, p.986, 2017.

L. D. Liu, M. Huang, P. Dai, T. Liu, S. Fan et al., Intrinsic nucleotide preference of Diversifying Base editors guides antibody ex vivo affinity maturation, Cell Rep, vol.25, issue.4, pp.884-892, 2018.

E. T. Boder, K. S. Midelfort, and K. D. Wittrup, Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity, Proc Natl Acad Sci U S A, vol.97, issue.20, pp.10701-10706, 2000.

H. Persson, U. Kirik, L. Thornqvist, L. Greiff, F. Levander et al., In vitro evolution of antibodies inspired by in vivo evolution, Front Immunol, vol.9, p.1391, 2018.

K. G. Macdonald, R. E. Hoeppli, Q. Huang, J. Gillies, D. S. Luciani et al., Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor, J Clin Invest, vol.126, issue.4, pp.1413-1437, 2016.

F. Noyan, K. Zimmermann, M. Hardtke-wolenski, A. Knoefel, E. Schulde et al., Prevention of allograft rejection by use of regulatory T cells with an MHC-specific chimeric antigen receptor, Am J Transplant, vol.17, issue.4, pp.917-947, 2017.