In vivo resorption of injectable apatitic calcium phosphate cements: Critical role of the intergranular microstructure - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Journal of Biomedical Materials Research Part B: Applied Biomaterials Année : 2019

In vivo resorption of injectable apatitic calcium phosphate cements: Critical role of the intergranular microstructure

Résumé

The in vivo resorption rate of two injectable apatitic calcium phosphate cements used in clinics (Graftys® HBS and NORIAN®) was compared, using a GLP study based on an animal model of critical-sized bone defect. To rationalize the markedly different biological properties observed for both cements, key physical features were investigated, including permeability and water-accessible porosity, total porosity measured by mercury intrusion and gravimetry, and microstructure. Due to a different concept for creating porosity between the two cements investigated in this study, a markedly different microstructural arrangement of apatite crystals was observed in the intergranular space, which was found to significantly influence both the mechanical strength and in vivo degradation of the two CPCs.
Fichier principal
Vignette du fichier
Publi Perméabilité.pdf (1.85 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03008174 , version 1 (16-11-2020)

Identifiants

Citer

Myriam Le Ferrec, Charlotte Mellier, François-Xavier Lefèvre, Florian Boukhechba, Pascal Janvier, et al.. In vivo resorption of injectable apatitic calcium phosphate cements: Critical role of the intergranular microstructure. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2019, 108 (2), pp.367-376. ⟨10.1002/jbm.b.34395⟩. ⟨hal-03008174⟩
119 Consultations
178 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More