Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance

Manuel Lasalle 1 Vanessa Hoguet 1 Nathalie Hennuyer 2 Florence Leroux 1 Catherine Piveteau 1 Loic Belloy 2 Sophie Lestavel 2 Emmanuelle Vallez 2 Emilie Dorchies 2 Isabelle Duplan 2 Emmanuel Sevin 3 Maxime Culot 3 Fabien Gosselet 3 Rajâa Boulahjar 1 Adrien Herledan 1 Bart Staels 2 Benoit Déprez 1 Anne Tailleux 2 Julie Charton 1
1 M2SV - Médicaments et molécules pour agir sur les Systèmes Vivants-U 1177
2 EGID - Récepteurs nucléaires, maladies cardiovasculaires et diabète
3 LBHE - Laboratoire de Physiopathologie de la Barrière Hémato-Encéphalique
Keywords : Aminothioimidazole TGR5 glucose tolerance GLP-1
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Submitted on : Tuesday, April 30, 2019 - 11:44:49 AM
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Manuel Lasalle, Vanessa Hoguet, Nathalie Hennuyer, Florence Leroux, Catherine Piveteau, et al.. Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance. Journal of Medicinal Chemistry, American Chemical Society, 2017, 60 (10), pp.4185-4211. ⟨10.1021/acs.jmedchem.6b01873⟩. ⟨inserm-02115415⟩

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