Circulating tumor cells as a tool for assessing tumor heterogeneity
Résumé
Tumor heterogeneity is the major cause of failure in cancer prognosis and prediction. Accurately
detecting heterogeneity for the development of biomarkers and the detection of the clones
resistant to therapy is one of the main goals of contemporary medicine. Metastases belong to the
natural history of cancer. The present review gives an overview on the origin of tumor
heterogeneity. Recent progress has made it possible to isolate and characterize circulating tumor
cells (CTCs), which are the drivers of the disease between the primary sites and metastatic foci.
The most recent methods for characterizing CTCs are summarized and we discuss the power of
CTC profiling for analyzing tumor heterogeneity in early and advanced diseases.
Origine : Fichiers produits par l'(les) auteur(s)
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