S. Tabrez, M. Priyadarshini, and S. Priyamvada, Gene-environment interactions in heavy metal and pesticide carcinogenesis, Mutat Res Genet Toxicol Environ Mutagen, vol.760, pp.1-9, 2014.

M. E. Schinasi-l-leon, Non-Hodgkin lymphoma and occupational exposure to agricultural pesticide chemical groups and active ingredients: A systematic review and meta-analysis

, Int J Environ Res Public Health, vol.23, issue.11, pp.4449-4527, 2014.

A. Bonner and M. R. , Occupational pesticide exposures and cancer risk: A review, J Toxicol Environ Health B Crit Rev, vol.15, pp.238-263, 2012.

A. Ewence, S. Brescia, and J. I. , An approach to the identification and regulation of endocrine disrupting pesticides, Food Chem Toxicol, vol.78, pp.214-220, 2015.

J. T. Cannon-jr-greenamyre, The role of environmental exposures in neurodegeneration and neurodegenerative diseases, Toxicol Sci, vol.124, pp.225-250, 2011.

J. R. Roberts and C. J. Karr, Pesticide exposure in children, Pediatrics, vol.130, pp.1765-1788, 2012.

V. A. Rauh, F. P. Perera, and M. K. Horton, Brain anomalies in children exposed prenatally to a common organophosphate pesticide, Proc Natl Acad Sci, vol.109, pp.7871-7876, 2012.

M. C. Alavanja, Introduction: Pesticides use and exposure extensive worldwide, Rev Environ Health, vol.24, pp.303-309, 2009.
DOI : 10.1515/reveh.2009.24.4.303

, Center for Disease Control and Prevention. Available at, 2016.

, Annual Report on Pesticide Residues according to Article 32 of Regulation (EC) No 396/2005, EFSA Journal, vol.8, p.440, 2010.

, European Food Safety Authority. The 2010 European Union Report on Pesticide Residues in Food, EFSA J, vol.11, p.808, 2013.

A. F. Hernandez, T. Parron, and A. M. Tsatsakis, Toxic effects of pesticide mixtures at a molecular level: their relevance to human health, Toxicology, vol.307, pp.136-145, 2012.

S. Chatterjee, M. Chaklader, and P. Basak, An animal model of chronic aplastic bone marrow failure following pesticide exposure in mice, Int J Stem Cells, vol.3, pp.54-62, 2010.

M. Valtieri and A. Sorrentino, The mesenchymal stromal cell contribution to homeostasis, J Cell Physiol, vol.217, pp.296-300, 2008.

A. Sorrentino, M. Ferracin, and G. Castelli, Isolation and characterization of CD1461 multipotent mesenchymal stromal cells, Exp Hematol, vol.36, pp.1035-1046, 2008.

P. Bianco, Mesenchymal" stem cells, Annu Rev Cell Dev Biol, vol.30, pp.677-704, 2014.
URL : https://hal.archives-ouvertes.fr/inserm-00465969

A. Reinisch, N. Etchart, and D. Thomas, Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation, Blood, vol.125, pp.249-260, 2014.

S. Liu, C. Ginestier, and S. J. Ou, Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks, Cancer Res, vol.71, pp.614-624, 2011.
URL : https://hal.archives-ouvertes.fr/hal-01431944

A. E. Karnoub, A. B. Dash, and A. P. Vo, Mesenchymal stem cells within tumour stroma promote breast cancer metastasis, Nature, vol.449, pp.557-563, 2007.
DOI : 10.1038/nature06188

P. Avril, L. Nail, L. R. Brennan, and M. A. , Mesenchymal stem cells increase proliferation but do not change quiescent state of osteosarcoma cells: Potential implications according to the tumor resection status, J Bone Oncol, vol.5, pp.5-14, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-01792555

F. T. Martin, R. M. Dwyer, and J. Kelly, Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT), Breast Cancer Res Treat, vol.124, pp.317-326, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00530824

P. Perrot, J. Rousseau, and A. L. Bouffaut, Safety concern between autologous fat graft, mesenchymal stem cell and osteosarcoma recurrence, PloS One, vol.5, p.10999, 2010.
DOI : 10.1371/journal.pone.0010999

URL : https://hal.archives-ouvertes.fr/inserm-00667931

M. A. Brennan, A. Renaud, and A. L. Gamblin, 3D cell culture and osteogenic differentiation of human bone marrow stromal cells plated onto jet-sprayed or electrospun microfiber scaffolds, Biomed Mater, vol.10, p.45019, 2015.

M. A. Brennan, A. Renaud, and J. Amiaud,

, Pre-clinical studies of bone regeneration with human bone marrow stromal cells and biphasic calcium phosphate, Stem Cell Res Ther, vol.5, p.114, 2014.

M. Dominici, L. Blanc, K. Mueller, and I. , Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement, Cytotherapy, vol.8, pp.315-317, 2006.

. Livak-kj-schmittgen and . Td, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method, Methods, vol.25, pp.402-408, 2001.

L. Oliver, E. Hue, and J. Rossignol, Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation, PLoS One, vol.6, issue.19820, 2011.
URL : https://hal.archives-ouvertes.fr/hal-01968410

D. A. Gewirtz, Autophagy and senescence: A partnership in search of definition, Autophagy, vol.9, pp.808-812, 2013.

L. Oliver, E. Hue, and M. Priault, Basal autophagy decreased during the differentiation of human adult mesenchymal stem cells, Stem Cells Dev, vol.21, pp.2779-2788, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00703317

J. M. Funes, M. Quintero, and S. Henderson, Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production, Proc Natl Acad Sci, vol.104, pp.6223-6228, 2007.

T. Kuilman, C. Michaloglou, and W. J. Mooi, The essence of senescence, Genes Dev, vol.24, pp.2463-2479, 2010.

R. Saxena and D. K. Garg-p-jain, In Vitro Antioxidant Effect of Vitamin E on Oxidative Stress Induced due to Pesticides in Rat Erythrocytes, Toxicol Int, vol.18, pp.73-76, 2011.

H. P. Olgun-s-misra, Pesticides induced oxidative stress in thymocytes, Mol Cell Biochem, vol.290, pp.137-144, 2006.

M. Abdollahi, A. Ranjbar, and S. Shadnia, Pesticides and oxidative stress: a review, Med Sci Monit, vol.10, pp.141-147, 2004.

H. Rodriguez-rocha, A. Garcia-garcia, and C. Pickett, Compartmentalized oxidative stress in dopaminergic cell death induced by pesticides and complex I inhibitors: distinct roles of superoxide anion and superoxide dismutases. Free Radic, Biol Med, vol.61, pp.370-383, 2013.

M. Karami-mohajeri-s-abdollahi, Mitochondrial dysfunction and organophosphorus compounds, Toxicol Appl Pharmacol, vol.270, pp.39-44, 2013.

J. Handy-de-loscalzo, Redox regulation of mitochondrial function, Antioxid Redox Signal, vol.16, pp.1323-1367, 2012.

D. V. Ziegler, C. D. Wiley, and M. C. Velarde, Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging, Aging Cell, vol.14, pp.1-7, 2015.

G. Pattappa, H. K. Heywood, and J. D. De-bruijn, The metabolism of human mesenchymal stem cells during proliferation and differentiation, J Cell Physiol, vol.226, pp.2562-2570, 2011.

M. C. Alavanja, M. K. Ross, and M. R. Bonner, Increased cancer burden among pesticide applicators and others due to pesticide exposure, CA Cancer J Clin, vol.63, pp.120-142, 2013.

W. H. Goodson, L. Lowe, and D. O. Carpenter, Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: The challenge ahead, Carcinogenesis, vol.36, issue.1, pp.254-296, 2015.
URL : https://hal.archives-ouvertes.fr/pasteur-01352152

M. Loaiza-n-demaria, Cellular senescence and tumor promotion: Is aging the key? Biochim, Biophys Acta, vol.1865, pp.155-167, 2016.

S. Weichenthal, C. Moase, and P. Chan, A review of pesticide exposure and cancer incidence in the agricultural health study cohort, Cienc Saude Colet, vol.17, pp.255-270, 2012.

S. Weichenthal, C. Moase, and P. Chan, A review of pesticide exposure and cancer incidence in the Agricultural Health Study cohort, Environ Health Perspect, vol.118, pp.1117-1125, 2010.

M. Merhi, C. Demur, and C. Racaud-sultan, Gender-linked haematopoietic and metabolic disturbances induced by a pesticide mixture administered at low dose to mice, Toxicology, vol.267, pp.80-90, 2010.

S. Chatterjee, P. Basak, and M. Chaklader, Pesticide induced alterations in marrow physiology and depletion of stem and stromal progenitor population: an experimental model to study the toxic effects of pesticide, Environ Toxicol, vol.29, pp.84-97, 2011.

R. Mesnage, N. Defarge, S. De-vendomois, and J. , Major pesticides are more toxic to human cells than their declared active principles, Biomed Res Int, p.179691, 2014.

D. Brubacher, U. Moser, and P. Jordan, Vitamin C concentrations in plasma as a function of intake: A meta-analysis, Int J Vitam Nutr Res, vol.70, pp.226-237, 2000.

M. Karami-mohajeri-s-abdollahi, Toxic influence of organophosphate, carbamate, and organochlorine pesticides on cellular metabolism of lipids, proteins, and carbohydrates: a systematic review, Hum Exp Toxicol, vol.30, pp.1119-1140, 2011.

D. G. Brand-md-nicholls, Assessing mitochondrial dysfunction in cells, Biochem J, vol.435, pp.297-312, 2011.

M. A. Marques-torrejon, E. Porlan, and A. Banito, Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression, Cell Stem Cell, vol.12, pp.88-100, 2013.

S. Takeshita, T. Fumoto, and Y. Naoe, Age-related marrow adipogenesis is linked to increased expression of RANKL, J Biol Chem, vol.289, pp.16699-16710, 2014.

Z. Belaid-choucair, Y. Lepelletier, and G. Poncin, Human bone marrow adipocytes block granulopoiesis through neuropilin-1-induced granulocyte colony-stimulating factor inhibition, STEM CELLS, vol.26, pp.1556-1564, 2008.
DOI : 10.1634/stemcells.2008-0068

URL : https://stemcellsjournals.onlinelibrary.wiley.com/doi/pdf/10.1634/stemcells.2008-0068

J. Choi, S. J. Curtis, and D. M. Roy, Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency, Am J Pathol, vol.177, pp.2645-2658, 2010.

J. Guarnerio, L. Riccardi, and R. Taulli, A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells, Cancer Discov, vol.5, pp.396-409, 2015.

R. Rubio, J. Garcia-castro, and I. Gutierrezaranda, Deficiency in p53 but not retinoblastoma induces the transformation of mesenchymal stem cells in vitro and initiates leiomyosarcoma in vivo, Cancer Res, vol.70, pp.4185-4194, 2010.