Energy metabolism in the liver, Compr Physiol, vol.4, pp.177-197, 2014. ,
Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications, Diabet Med, vol.27, pp.136-142, 2010. ,
Gut-brain glucose signaling in energy homeostasis, Cell Metab, vol.25, pp.1231-1242, 2017. ,
Molecular pathophysiology of hepatic glucose production, Mol Aspects Med, vol.46, pp.21-33, 2015. ,
Transcription factor networks regulating hepatic fatty acid metabolism, Biochim Biophys Acta, vol.1851, pp.2-8, 2015. ,
Hepatic glucose sensing and integrative pathways in the liver, Cell Mol Life Sci, vol.71, pp.1453-1467, 2014. ,
Hormonal regulation of hepatic glucose production in health and disease, Cell Metab, vol.14, pp.9-19, 2011. ,
Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis, Annu Rev Physiol, vol.54, pp.885-909, 1992. ,
The rat fructose-1,6-bisphosphatase gene. Structure and regulation of expression, J Biol Chem, vol.266, pp.2115-2120, 1991. ,
Glucose-6-phosphatase catalytic subunit gene family, J Biol Chem, vol.284, pp.29241-29245, 2009. ,
The constitutive activation of Egr-1/C/EBPa mediates the development of type 2 diabetes mellitus by enhancing hepatic gluconeogenesis, Am J Pathol, vol.185, pp.513-523, 2015. ,
Targeting hepatic glucose metabolism in the treatment of type 2 diabetes, Nat Rev Drug Discov, vol.15, pp.786-804, 2016. ,
Nuclear bile acid signaling through the farnesoid X receptor, Cell Mol Life Sci, vol.72, pp.1631-1650, 2015. ,
Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity, Diabetes, vol.60, pp.1861-1871, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-00605738
Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells, Nat Commun, vol.6, p.7629, 2015. ,
The Farnesoid X Receptor Modulates Hepatic Carbohydrate Metabolism during the Fasting-Refeeding Transition, J Biol Chem, vol.280, pp.29971-29979, 2005. ,
Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes, Mol Cell Biol, vol.33, pp.2202-2211, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-00806064
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice, Proc Natl Acad Sci, vol.103, pp.1006-1011, 2006. ,
FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats, J Lipid Res, vol.51, pp.771-784, 2010. ,
Farnesoid X receptor is essential for normal glucose homeostasis, J Clin Invest, vol.116, pp.1102-1109, 2006. ,
The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism, Nat Commun, vol.4, 1937. ,
Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and insulin resistance, Pharm Res, vol.30, pp.1447-1457, 2013. ,
Transcriptional repression of the gluconeogenic gene PEPCK by the orphan nuclear receptor SHP through inhibitory interaction with C/EBPalpha, Biochem J, vol.402, pp.567-574, 2007. ,
Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1, J Biol Chem, vol.279, pp.23158-23165, 2004. ,
FXR-deficiency confers increased susceptibility to torpor, FEBS Lett, vol.581, pp.5191-5198, 2007. ,
URL : https://hal.archives-ouvertes.fr/inserm-00409558
Transient impairment of the adaptive response to fasting in FXR-deficient mice, FEBS Lett, vol.579, pp.4076-4080, 2005. ,
The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice, J Biol Chem, vol.281, pp.11039-11049, 2006. ,
Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition, FASEB J, vol.26, pp.3021-3031, 2012. ,
The hepatic orosomucoid/alpha1-acid glycoprotein gene cluster is regulated by the nuclear bile acid receptor FXR, Endocrinology, vol.154, pp.3690-3701, 2013. ,
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis, Cell, vol.102, pp.731-744, 2000. ,
Glucose sensing O-GlcNAcylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR), Hepatology, vol.59, pp.2022-2033, 2014. ,
Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk, J Clin Invest, vol.124, pp.1037-1051, 2014. ,
Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity, Mol Endocrinol, vol.22, pp.2433-2447, 2008. ,
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A, Proc Natl Acad Sci, vol.97, pp.11960-11965, 2000. ,
Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine, Hepatology, vol.51, pp.1410-1419, 2010. ,
Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver, BMC Genomics, vol.14, p.337, 2013. ,
, The Encode Project Consortium. An integrated encyclopedia of DNA elements in the human genome, Nature, vol.489, pp.57-74, 2012.
Identification of a nuclear receptor that is activated by farnesol metabolites, Cell, vol.81, pp.687-693, 1995. ,
Nuclear export-independent inhibition of Foxa2 by insulin, J Biol Chem, vol.284, pp.24816-24824, 2009. ,
Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization, Proc Natl Acad Sci, vol.100, pp.11624-11629, 2003. ,
Foxa2-dependent hepatic gene regulatory networks depend on physiological state, Physiol Genomics, vol.38, pp.186-195, 2009. ,
Speciesspecific strategies underlying conserved functions of metabolic transcription factors, Mol Endocrinol, vol.25, pp.694-706, 2011. ,
Nucleosomebinding affinity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA, Genes Dev, vol.23, pp.804-809, 2009. ,
Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease, Gastroenterology, vol.152, p.1673, 2017. ,
Regulation of carbohydrate metabolism by the farnesoid X receptor, Endocrinology, vol.146, pp.984-991, 2005. ,
Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure, J Biol Chem, vol.286, pp.26913-26920, 2011. ,
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states, Cell Metab, vol.10, pp.392-404, 2009. ,
SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling, Hepatology, vol.59, pp.1972-1983, 2014. ,
Nuclear proteomics uncovers diurnal regulatory landscapes in mouse liver, Cell Metab, vol.25, pp.102-117, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-02187195
Phosphorylation is a central mechanism for circadian control of metabolism and physiology, Cell Metab, vol.25, pp.118-127, 2017. ,
The logic of transcriptional regulator recruitment architecture at cis-regulatory modules controlling liver functions ,
, Genome Res, vol.27, pp.985-996, 2017.
Role of bile acids and bile acid receptors in metabolic regulation, Physiol Rev, vol.89, pp.147-191, 2009. ,
Role of nuclear receptor SHP in metabolism and cancer, Biochim Biophys Acta, vol.1812, pp.893-908, 2011. ,
Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding, Mol Endocrinol, vol.18, pp.2880-2894, 2004. ,
Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolism, Cell Metab, vol.17, pp.436-447, 2013. ,
Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes, Nature, vol.432, pp.1027-1032, 2004. ,