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Interest of FDG-PET in the Management of Mantle Cell Lymphoma

Abstract : FDG-PET changed response assessment and therapy strategy in diffuse large B-cell lymphoma and Hodgkin disease lymphoma. The value of FDG-PET evaluation in MCL has not been extensively studied and a recent expert consensus highlighted the need for more studies addressing this question. Data of the literature show the value of FDG-PET at baseline in patients with MCL, underlining the good sensitivity of this examination for the initial staging of this pathology, but also the potential impact of semi-quantitative analysis in this indication. The determination of SUVmax at diagnosis might indeed provide important prognostic information. Some studies also suggest the potential value of early and end-of-treatment metabolic assessment in MCL, but these results need to be validated in standardized prospective studies. These results also underlie the need to integrate FDG-PET results into MCL treatment strategy to improve disease management in identifying patients who might benefit from more intensive therapy.
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Submitted on : Monday, April 15, 2019 - 4:31:17 PM
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Clément Bailly, Thomas Carlier, Cyrille Touzeau, Nicolas Arlicot, Françoise Kraeber-Bodéré, et al.. Interest of FDG-PET in the Management of Mantle Cell Lymphoma. Frontiers in Medicine, Frontiers media, 2019, 6, Epub ahead of print. ⟨10.3389/fmed.2019.00070⟩. ⟨inserm-02100231⟩



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