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L'immuno-virothérapie oncolytique, une stratégie émergente de traitement du cancer

Jean-François Fonteneau 1, 2, * Eric Quemeneur 3 
* Corresponding author
1 CRCINA-ÉQUIPE 4 - Immunogenic Cell Death and Mesothelioma Therapy
CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
Abstract : Oncolytic immuno-virotherapy consists in using replicative viruses to target tumor cells, causes their selective lysis, and thus activates the anti-tumor immune response. This approach, whose concept is relatively old, has become a therapeutic reality since 2015 with the approval of a first product, T-Vec, for the treatment of metastatic melanoma. In this review, we recall the principle of oncolytic therapy and its positive effects on the anti-tumor immune response. The mechanisms involved justify their use in combination with immune checkpoints inhibitors. In parallel with the many preclinical advances, clinical development is very active. There are about fifty trials of phases 1 to 3 in progress in a wide variety of indications, routes of administration and combination. We bet that this multifunctional emergent class, which reprograms the tumor microenvironment (for converting “cold” tumors into “hot” tumors), could quickly become a new valuable weapon in the oncologist’s therapeutic arsenal.
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Submitted on : Monday, April 15, 2019 - 3:24:49 PM
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  • HAL Id : inserm-02100092, version 1



Jean-François Fonteneau, Eric Quemeneur. L'immuno-virothérapie oncolytique, une stratégie émergente de traitement du cancer. Immunité & Cancer, 2019, 3 (1), Epub ahead of print. ⟨inserm-02100092⟩



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