Positive margins after surgical excision of locoregional cutaneous melanoma metastasis and their impact on patient outcome

Barbara Bregeon 1 Jean-Michel Nguyen 2, 3 Emilie Varey 1, 2, 4 Gaëlle Quereux 2, 1, 4 Mélanie Saint-Jean 2, 1, 4 Lucie Peuvrel 2, 1, 4 Amir Khammari 2, 1, 4 Brigitte Dréno 2, 1, 4, *
* Corresponding author
1 Service de dermatologie [Nantes]
2 CRCINA - Département INCIT - Equipe 2 - Clinical and translational research in skin cancer
CRCINA - Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers
3 SEB-PIMESP [CHU Nantes]
4 CIC Nantes - Centre d’Investigation Clinique de Nantes
Abstract : For melanoma patients, surgery is a standard treatment for locoregional skin metastasis (LSM). To assess the frequency and risk factors for positive margins after excision of LSM and their impact on patient overall survival (OS) and progression-free survival (PFS). A monocentric, retrospective observational study was performed including 87 patients with LSM who had undergone surgical excision. Positive margins were found in 45% of patients after excision. After additional excision, 28% of patients still had positive margins. Interestingly, there was no difference in PFS or OS for clear margins after the first or additional excision or for margins that remained positive without additional excision. LSM size was the only identified predictive factor for positive margins. This is the first reported study investigating the frequency of, and risk factors for positive margins of cutaneous LSM, which raises the question of whether additional excision should be performed following positive margin excision.
Keywords : locoregional skin metastasis melanoma overall survival positive margin progression-free survival risk factor surgery
Document type :
Journal articles
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https://www.hal.inserm.fr/inserm-02099813
Contributor : Elizabeth Bernardo <>
Submitted on : Monday, April 15, 2019 - 12:02:57 PM
Last modification on : Monday, May 20, 2019 - 3:32:02 PM

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Barbara Bregeon, Jean-Michel Nguyen, Emilie Varey, Gaëlle Quereux, Mélanie Saint-Jean, et al.. Positive margins after surgical excision of locoregional cutaneous melanoma metastasis and their impact on patient outcome. European Journal of Dermatology, John Libbey Eurotext, 2018, 28 (5), pp.661-667. ⟨10.1684/ejd.2018.3402⟩. ⟨inserm-02099813⟩

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