Plasmodium falciparum Plasmepsin 2 Duplications, West Africa

Abstract : Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa.
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Juliana Inoue, Miguel Silva, Bakary Fofana, Kassim Sanogo, Andreas Mårtensson, et al.. Plasmodium falciparum Plasmepsin 2 Duplications, West Africa. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2018, 24 (8), pp.1591-1593. ⟨10.3201/eid2408.180370⟩. ⟨inserm-02093060⟩

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