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Plasmodium falciparum Plasmepsin 2 Duplications, West Africa

Juliana Inoue 1 Miguel Silva 2 Bakary Fofana 3 Kassim Sanogo 3 Andreas Mårtensson 1 Issaka Sagara 3 Anders Bjorkman 4 Maria Isabel Veiga 2 Pedro Eduardo Ferreira 2 Abdoulaye Djimde 3 José Pedro Gil 1, 4, 5
1 Uppsala University [Uppsala, Sweden]
2 University of Minho [Braga, Portugal]
3 University of Science, Techniques, and Technologies [Bamako, Mali]
4 Karolinska Institutet [Stockholm, Sweden]
5 Universidade de Lisboa [Lisbon, Portugal]
Abstract : Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa.
Keywords : DHA-PPQ Pfpm2 Plasmodium falciparum West Africa dihydroartemisinin-piperaquine malaria moquitoborne diseases piperaquine plasmepsin 2 resistance vector-borne infections
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Submitted on : Monday, April 8, 2019 - 4:06:33 PM
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Juliana Inoue, Miguel Silva, Bakary Fofana, Kassim Sanogo, Andreas Mårtensson, et al.. Plasmodium falciparum Plasmepsin 2 Duplications, West Africa. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2018, 24 (8), pp.1591-1593. ⟨10.3201/eid2408.180370⟩. ⟨inserm-02093060⟩

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