L. Qin, P. B. Gilbert, L. Corey, M. J. Mcelrath, and S. G. Self, A framework for assessing immunological correlates of protection in vaccine trials, J. Infect. Dis, vol.196, pp.1304-1312, 2007.

P. B. Gilbert, L. Qin, and S. G. Self, Evaluating a surrogate endpoint at three levels, with application to vaccine development, Stat. Med, vol.27, pp.4758-4778, 2008.
DOI : 10.1002/sim.3122

URL : http://europepmc.org/articles/pmc2646675?pdf=render

L. Defrancesco, The 'anti-hype' vaccine, Nat. Biotechnol, vol.35, pp.193-197, 2017.

B. Pulendran and R. Ahmed, Immunological mechanisms of vaccination, Nat. Immunol, vol.12, pp.509-517, 2011.
DOI : 10.1038/ni.2039

URL : http://europepmc.org/articles/pmc3253344?pdf=render

R. Verbeke, Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: restoring the immunogenicity of immunosilent mRNA, J. Control. Release, vol.266, pp.287-300, 2017.

M. Fotin-mleczek, Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity, J. Immunother, vol.34, pp.1-15, 2011.
DOI : 10.1097/cji.0b013e3181f7dbe8

C. Lonez, M. Vandenbranden, and J. Ruysschaert, Cationic lipids activate intracellular signaling pathways, Adv. Drug Deliv. Rev, vol.64, pp.1749-1758, 2012.
DOI : 10.1016/j.addr.2012.05.009

C. Pollard, Type I IFN counteracts the induction of antigen-specific immune responses by lipid-based delivery of mRNA vaccines, Mol. Ther, vol.21, pp.251-259, 2013.

B. Petsch, Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection, Nat. Biotechnol, vol.30, pp.1210-1216, 2012.

N. Pardi, Zika virus protection by a single low-dose nucleosidemodified mRNA vaccination, Nature, vol.543, pp.248-251, 2017.
DOI : 10.1038/nature21428

URL : https://www.nature.com/articles/nature21428.pdf

D. Benteyn, C. Heirman, A. Bonehill, K. Thielemans, and K. Breckpot, mRNA-based dendritic cell vaccines, Expert Rev. Vaccines, vol.14, pp.161-176, 2015.
DOI : 10.1586/14760584.2014.957684

M. Diken, Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation, Gene Ther, vol.18, pp.702-708, 2011.

K. Broos, Particle-mediated intravenous delivery of antigen mRNA results in strong antigen-specific T-cell responses despite the induction of type I interferon, Mol. Ther. Nucleic Acids, vol.5, p.326, 2016.

S. Stoll, J. Delon, T. M. Brotz, and R. N. Germain, Dynamic imaging of T cell-dendritic cell interactions in lymph nodes, Science, vol.296, pp.1873-1876, 2002.

S. Van-aalst, Routing dependent immune responses after experimental R848-adjuvated vaccination, Vaccine, vol.36, pp.1405-1413, 2018.

S. E. Frey, Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-naive subjects, Vaccine, vol.33, pp.5225-5234, 2015.

L. Desigaux, Self-assembled lamellar complexes of siRNA with lipidic aminoglycoside derivatives promote efficient siRNA delivery and interference, Proc. Natl Acad. Sci. USA, vol.104, pp.16534-16539, 2007.

D. Habrant, Design of ionizable lipids to overcome the limiting step of endosomal escape: application in the intracellular delivery of mRNA, DNA, and siRNA, J. Med. Chem, vol.59, pp.3046-3062, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01831743

T. Colombani, Self-assembling complexes between binary mixtures of lipids with different linkers and nucleic acids promote universal mRNA, DNA and siRNA delivery, J. Control. Release, vol.249, pp.131-142, 2017.
DOI : 10.1016/j.jconrel.2017.01.041

URL : https://hal.archives-ouvertes.fr/inserm-01473687

J. L. Kirschman, Characterizing exogenous mRNA delivery, trafficking, cytoplasmic release and RNA-protein correlations at the level of single cells, Nucleic Acids Res, vol.45, p.113, 2017.

E. Alonas, D. Vanover, E. Blanchard, C. Zurla, and P. J. Santangelo, Imaging viral RNA using multiply labeled tetravalent RNA imaging probes in live cells, Methods, vol.98, pp.91-98, 2016.

S. M. Bhosle, Unifying in vitro and in vivo IVT mRNA expression discrepancies in skeletal muscle via mechanotransduction, Biomaterials, vol.159, pp.189-203, 2018.

F. Liang, Efficient targeting and activation of antigen-presenting cells in vivo after modified mRNA vaccine administration in rhesus macaques, Mol. Ther, vol.25, pp.2635-2647, 2017.

A. V. Shustov, P. W. Mason, and I. Frolov, Production of pseudoinfectious yellow fever virus with a two-component genome, J. Virol, vol.81, pp.11737-11748, 2007.

A. Op-de-beeck, Role of the transmembrane domains of prM and E proteins in the formation of yellow fever virus envelope, J. Virol, vol.77, pp.813-820, 2003.

W. W. Moses, Fundamental limits of spatial resolution in PET, Nucl. Instrum. Methods Phys. Res. A, vol.648, pp.236-240, 2011.

M. Pauthner, Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunization using optimized approaches, Immunity, vol.46, pp.1073-1088, 2017.

F. Lu and H. Hogenesch, Kinetics of the inflammatory response following intramuscular injection of aluminum adjuvant, Vaccine, vol.31, pp.3979-3986, 2013.

S. Calabro, Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes, Vaccine, vol.29, pp.1812-1823, 2011.

S. N. Thomas, N. A. Rohner, and E. E. Edwards, Implications of lymphatic transport to lymph nodes in immunity and immunotherapy, Annu. Rev. Biomed. Eng, vol.18, pp.207-233, 2016.

K. J. Wood, A. Bushell, and J. Hester, Regulatory immune cells in transplantation, Nat. Rev. Immunol, vol.12, pp.417-430, 2012.

M. L. Ford, A. B. Adams, and T. C. Pearson, Targeting co-stimulatory pathways: transplantation and autoimmunity, Nat. Rev. Nephrol, vol.10, pp.14-24, 2014.

S. G. Reed, M. T. Orr, and C. B. Fox, Key roles of adjuvants in modern vaccines, Nat. Med, vol.19, pp.1597-1608, 2013.

R. P. Deering, S. Kommareddy, J. B. Ulmer, L. A. Brito, and A. J. Geall, Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines, Expert Opin. Drug Deliv, vol.11, pp.885-899, 2014.

F. Liang and K. Loré, Local innate immune responses in the vaccine adjuvant-injected muscle, Clin. Transl. Immunol, vol.5, p.74, 2016.

F. Liang, Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake, Sci. Transl. Med, vol.9, p.2094, 2017.